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View Structure Prediction Details

Protein: Rassf-PA
Organism: Drosophila melanogaster
Length: 806 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rassf-PA.

Description E-value Query
Range
Subject
Range
gi|119115279, gi... - gi|119115279|ref|XP_310992.3| ENSANGP00000008121 [Anopheles gambiae str. PEST], gi|116130759|gb|EAA0...
402.0 [0..1] [806..1]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKCHKCGKP VYFAERKQSI GYDWHPECLR CEECGKRLNP GQHAEHKSVP YCHVPCYGAL  60
   61 FGPQLFGHGT RVESHKSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1imlA
Description: CYSTEINE RICH INTESTINAL PROTEIN, NMR, 48 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.32420977112004 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription regulator activity 1.18816040284456 bayes_pls_golite062009
DNA binding 1.00346200943179 bayes_pls_golite062009
nucleic acid binding 0.86280381479968 bayes_pls_golite062009
transcription factor activity 0.441713135779151 bayes_pls_golite062009
transcription factor binding 0.30385317974375 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [79-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVKGAQKPTG AQANGPPLPR DHLESKLKVY NQFYDNKSLE IRSREVNNRL VLEGALRVYW  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [139-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVQGVIHLKE DDDQRILVRK RNSCRVSKAA NESSSDKENE ASESLAPPTT TTAEVDQLST  60
   61 DVSLSESMTF DSCSLNEISE LPTTPEDASA NTTANSKEQT NGNVCNDDED TTTTDSSGTL 120
  121 VEAPTASTSC VSSTLPSKLD RLEKLDWDDI DDLLQVERRH NDKDRIYETM PVKLPSSQSS 180
  181 SDSSPSKTST ETTTTTESSS TQSASTNTSS TDDFMTATGS LTANTNTQNT TTVSTTETSL 240
  241 DNFETCDDAT LKPIDFEDFK RSVHQDYVNG ANSFTEPNEG TLKRNQPIDP SRIHDSLKLY 300
  301 GENSAMSKSF NCEHALRSID PTLINDTMNL RSSVGSPHSA QRQYALQKSG SATVTSRDQK 360
  361 KPYQQGRQLF EKGINRSKSG PSCFV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.975
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [524-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSDSDDDDEA TLRPQRMATI RRSDIPQRYI QIQMDCYPKE NVAAASEGES SRADAPSITS  60
   61 GAAAGDELTQ TEDLYTASEG VDGPDGDGSA GLHVTEDGVV LRRPPRTGAS AIKRRSGNRR 120
  121 SRTKLKRRCS INGHYYNRET SFFTPPYG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [672-806]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQMSVWVSSM VTTTEVINLV LEKYKVDSSP GNFSLFIVRD NGEQKRLKDD EYPLITRVTL  60
   61 GPHEDVARIF LVDSRKTDEI SNEVAQFLNL SLPECRAILE RYDQELAREV AKIKERYAEL 120
  121 RRRIVSRMES LKVHL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.57
Match: 1wxaA
Description: Solution Structure of Ras-binding Domain in Mouse AF-6 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle