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View Structure Prediction Details

Protein: gi|123230977, gi...
Organism: Homo sapiens
Length: 276 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123230977, gi....

Description E-value Query
Range
Subject
Range
gi|109070671 - gi|109070671|ref|XP_001115562.1| PREDICTED: similar to proteasome beta 8 subunit isoform E2 proprote...
1.0E-79 [1..276] [1..276]
gi|114606757 - gi|114606757|ref|XP_001167272.1| PREDICTED: proteasome beta 8 subunit isoform 3 [Pan troglodytes]
1.0E-78 [1..276] [1..276]
PSMB8 - proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
5.0E-78 [1..276] [1..276]
PSB8_RAT - Proteasome subunit beta type-8 OS=Rattus norvegicus GN=Psmb8 PE=1 SV=3
3.0E-76 [1..273] [1..273]
gi|972988, gi|97... - gi|972988|gb|AAA75036.1| 20S proteasome subunit Lmp7 [Mus musculus], gi|972986|gb|AAA75035.1| 20S pr...
1.0E-74 [1..273] [1..273]
gi|74267608, gi|... - gi|94966773|ref|NP_001035570.1| proteasome beta 8 subunit [Bos taurus], gi|74267608|gb|AAI02171.1| P...
2.0E-74 [1..276] [1..276]

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Predicted Domain #1
Region A:
Residues: [1-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP TEFFQSLGGD  60
   61 GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA LRVNKVIEIN PYLLGTMSGC 120
  121 AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMMC QYRGMGLSMG SMICGWDKKG 180
  181 PGLYYVDEHG TRLSGNMFST GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS 240
  241 YSGGVVNMYH MKEDGWVKVE STDVSDLLHQ YREANQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.221849
Match: 1iruL
Description: Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
endopeptidase activity 6.91642761177919 bayes_pls_golite062009
peptidase activity 6.84511694091156 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 6.5973571808298 bayes_pls_golite062009
hydrolase activity 4.47652590304822 bayes_pls_golite062009
threonine-type endopeptidase activity 2.98214579292788 bayes_pls_golite062009
threonine-type peptidase activity 2.98214579292788 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009
binding 0.982918122186083 bayes_pls_golite062009
nucleic acid binding 0.448212653390607 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle