YRC Public Data Repository - Protein Structure Prediction

Protein:	SERA_ECO57
Organism:	Escherichia coli O157:H7
Length:	410 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SERA_ECO57.

Description	E-value	Query Range	Subject Range
gi\|90327037, gi\|... - gi\|90412059\|ref\|ZP_01220066.1\| phosphoglycerate dehydrogenase [Photobacterium profundum 3TCK], gi\|90...	425.0	[0..1]	[410..1]
gi\|90580301, gi\|... - gi\|90580301\|ref\|ZP_01236108.1\| Phosphoglycerate dehydrogenase [Vibrio angustum S14], gi\|90438603\|gb\|...	417.0	[0..1]	[410..1]
gi\|88796765, gi\|... - gi\|88796765\|ref\|ZP_01112416.1\| D-3-phosphoglycerate dehydrogenase [Alteromonas macleodii 'Deep ecoty...	417.0	[0..1]	[410..1]
gi\|27361062, gi\|... - gi\|27364916\|ref\|NP_760444.1\| D-3-phosphoglycerate dehydrogenase [Vibrio vulnificus CMCP6], gi\|273610...	417.0	[0..1]	[410..1]
gi\|77953234, gi\|... - gi\|77953234\|ref\|ZP_00817644.1\| D-3-phosphoglycerate dehydrogenase [Marinobacter aquaeolei VT8], gi\|7...	416.0	[0..1]	[410..31]
gi\|89074091, gi\|... - gi\|89074091\|ref\|ZP_01160590.1\| Phosphoglycerate dehydrogenase [Photobacterium sp. SKA34], gi\|8905002...	416.0	[0..1]	[410..1]
gi\|28899367, gi\|... - gi\|28899367\|ref\|NP_798972.1\| D-3-phosphoglycerate dehydrogenase [Vibrio parahaemolyticus RIMD 221063... gi\|28807603 - gi\|28807603\|dbj\|BAC60856.1\| D-3-phosphoglycerate dehydrogenase [Vibrio parahaemolyticus RIMD 2210633...	415.0	[0..1]	[410..1]
gi\|37199786, gi\|... - gi\|37681036\|ref\|NP_935645.1\| D-3-phosphoglycerate dehydrogenase [Vibrio vulnificus YJ016], gi\|371997...	415.0	[0..1]	[410..1]
gi\|71555670, gi\|... - gi\|71735117\|ref\|YP_276976.1\| D-3-phosphoglycerate dehydrogenase [Pseudomonas syringae pv. phaseolico...	415.0	[0..1]	[410..21]
gi\|52425798, gi\|... - gi\|52425798\|ref\|YP_088935.1\| D-3-phosphoglycerate dehydrogenase [Mannheimia succiniciproducens MBEL5...	413.0	[0..1]	[410..1]

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Predicted Domain #1

Region A:
Residues: [1-410]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVSLEKDK IKFLLVEGVH QKALESLRAA GYTNIEFHKG ALDDEQLKES IRDAHFIGLR  60
   61 SRTHLTEDVI NAAEKLVAIG CFCIGTNQVD LDAAAKRGIP VFNAPFSNTR SVAELVIGEL 120
  121 LLLLRGVPEA NAKAHRGVWN KLAAGSFEAR GKKLGIIGYG HIGTQLGILA ESLGMYVYFY 180
  181 DIENKLPLGN ATQVQHLSDL LNMSDVVSLH VPENPSTKNM MGAKEISLMK PGSLLINASR 240
  241 GTVVDIPALC DALASKHLAG AAIDVFPTEP ATNSDPFTSP LCEFDNVLLT PHIGGSTQEA 300
  301 QENIGLEVAG KLIKYSDNGS TLSAVNFPEV SLPLHGGRRL MHIHENRPGV LTALNKIFAE 360
  361 QGVNIAAQYL QTSAQMGYVV IDIEADEDVA EKALQAMKAI PGTIRARLLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	115.0
Match:	1ybaA
Description:	The active form of phosphoglycerate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	3.48670706716817	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.27460110663386	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	1.31022230162074	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.29842732066898	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
phosphoglycerate dehydrogenase activity	0.639509916626856	bayes_pls_golite062009
malate dehydrogenase activity	0.63606663166401	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
nucleic acid binding	0.148119368399653	bayes_pls_golite062009
DNA binding	0.0491903477459248	bayes_pls_golite062009
glyoxylate reductase activity	0.0221984076575323	bayes_pls_golite062009
transcription regulator activity	0.012678711735872	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: