YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|6690112
Organism:	Plasmodium falciparum
Length:	1205 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|6690112.

Description	E-value	Query Range	Subject Range
gi\|165914793, gi... - gi\|89104328\|ref\|ZP_01176874.1\| COG0021: Transketolase [Yersinia pestis biovar Orientalis str. IP275]... gi\|108778250, gi... - gi\|108806337\|ref\|YP_650253.1\| transketolase [Yersinia pestis Antiqua], gi\|108778250\|gb\|ABG12308.1\| t... gi\|108813283, gi... - gi\|229903742\|ref\|ZP_04518855.1\| transketolase 1 [Yersinia pestis Nepal516], gi\|229679512\|gb\|EEO75615... gi\|77632829, gi\|... - gi\|77632829\|ref\|ZP_00795015.1\| COG0021: Transketolase [Yersinia pestis Angola], gi\|162421897\|ref\|YP_... gi\|229837614, gi... - gi\|229837614\|ref\|ZP_04457776.1\| transketolase 1 [Yersinia pestis Pestoides A], gi\|229704302\|gb\|EEO91... gi\|229840838, gi... - gi\|229840838\|ref\|ZP_04460997.1\| transketolase 1 [Yersinia pestis biovar Orientalis str. PEXU2], gi\|2... gi\|22127186, gi\|... - gi\|22127186\|ref\|NP_670609.1\| transketolase [Yersinia pestis KIM], gi\|21960251\|gb\|AAM86860.1\|AE013932... gi\|229690909, gi... - gi\|229842599\|ref\|ZP_04462754.1\| transketolase 1 [Yersinia pestis biovar Orientalis str. India 195], ... gi\|25286327 - pir\|\|AG0113 transketolase (EC 2.2.1.1) [imported] - Yersinia pestis (strain CO92) gi\|16121231, gi\|... - gi\|218928099\|ref\|YP_002345974.1\| transketolase [Yersinia pestis CO92], gi\|16121231\|ref\|NP_404544.1\| ... gi\|45438122, gi\|... - gi\|45443254\|ref\|NP_994793.1\| transketolase [Yersinia pestis biovar Microtus str. 91001], gi\|45438122... gi\|149290678, gi... - gi\|149367064\|ref\|ZP_01889097.1\| transketolase 1 [Yersinia pestis CA88-4125], gi\|149290678\|gb\|EDM4075... gi\|165923095, gi... - gi\|165924895\|ref\|ZP_02220727.1\| transketolase [Yersinia pestis biovar Orientalis str. F1991016], gi\|... gi\|145209592, gi... - gi\|145597896\|ref\|YP_001161972.1\| transketolase [Yersinia pestis Pestoides F], gi\|145209592\|gb\|ABP389... gi\|166212847, gi... - gi\|166212847\|ref\|ZP_02238882.1\| transketolase [Yersinia pestis biovar Antiqua str. B42003004], gi\|16... gi\|165990786, gi... - gi\|166010300\|ref\|ZP_02231198.1\| transketolase [Yersinia pestis biovar Antiqua str. E1979001], gi\|165... gi\|166960043, gi... - gi\|167421906\|ref\|ZP_02313659.1\| transketolase [Yersinia pestis biovar Orientalis str. MG05-1020], gi... gi\|167050623, gi... - gi\|167399915\|ref\|ZP_02305433.1\| transketolase [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|16... gi\|167426715, gi... - gi\|167426715\|ref\|ZP_02318468.1\| transketolase [Yersinia pestis biovar Mediaevalis str. K1973002], gi...	702.0	[0..442]	[1139..9]
gi\|152959021, gi... - gi\|77630175\|ref\|ZP_00792761.1\| COG0021: Transketolase [Yersinia pseudotuberculosis IP 31758], gi\|153... gi\|170023099, gi... - gi\|170023099\|ref\|YP_001719604.1\| transketolase [Yersinia pseudotuberculosis YPIII], gi\|169749633\|gb\|... gi\|186896630, gi... - gi\|186896630\|ref\|YP_001873742.1\| transketolase [Yersinia pseudotuberculosis PB1/+], gi\|186699656\|gb\|... Q666P9\|Q666P9_YERPS - Transketolase 1 - Yersinia pseudotuberculosis gi\|51597508, gi\|... - gi\|51597508\|ref\|YP_071699.1\| transketolase [Yersinia pseudotuberculosis IP 32953], gi\|51590790\|emb\|C...	701.0	[0..442]	[1139..9]
gi\|77976323, gi\|... - gi\|77976323\|ref\|ZP_00831821.1\| COG0021: Transketolase [Yersinia intermedia ATCC 29909], gi\|238795136...	700.0	[0..442]	[1139..9]
TKT2_VIBPA - Transketolase 2 OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=tkt2 PE=3 SV=1 TKT2_VIBPA - Transketolase 2 OS=Vibrio parahaemolyticus GN=tkt2 PE=3 SV=1	699.0	[0..438]	[1139..4]
gi\|77974478 - gi\|77974478\|ref\|ZP_00830018.1\| COG0021: Transketolase [Yersinia frederiksenii ATCC 33641]	697.0	[0..442]	[1139..9]
gi\|238713432, gi... - gi\|77956699\|ref\|ZP_00820782.1\| COG0021: Transketolase [Yersinia bercovieri ATCC 43970], gi\|238785653...	696.0	[0..442]	[1139..9]
gi\|77961482 - gi\|77961482\|ref\|ZP_00825318.1\| COG0021: Transketolase [Yersinia mollaretii ATCC 43969]	695.0	[0..442]	[1139..9]
gi\|91190420, gi\|... - gi\|91224874\|ref\|ZP_01260134.1\| transketolase [Vibrio alginolyticus 12G01], gi\|91190420\|gb\|EAS76689.1...	691.0	[0..438]	[1139..4]
gi\|53756610, gi\|... - gi\|53802849\|ref\|YP_115427.1\| transketolase [Methylococcus capsulatus str. Bath], gi\|53756610\|gb\|AAU9...	686.0	[0..442]	[1136..9]

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Predicted Domain #1

Region A:
Residues: [1-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIFNYVFFKN FVPVVLYILL IIYINLNGMN NKNQIKTEKI YIKKLNRLSR KNSLCSSKNK  60
   61 IACLFDIGND DNRNTTYGYN VNVKNDDINS LLKNNYSNKL YMDKRKNINN VISTNKISGS 120
  121 ISNICSRNQK ENEQKRNKQR CLTQCHTYNM SHEQDKLAND NNRNNKKNFN LLFINYFNLK 180
  181 RMKNSLLNKD NFFYCKEKKL SFLHKAYKKK NCTFQNYSLK RKSNRDSHKL FSGEFDDYTN 240
  241 NNALYESEKK EYITLNNNNK NNNNKNNDNK NNDNNDYNNN NSCNNLGERS NHYDNYGGDN 300
  301 NNPCNNNNDK YDIGKYFKQI NTFINIDEYK TIYGDEIYKE IYELYVERNI PEYYERKYFS 360
  361 EDIKKSVLFD IDKYNDVEFE KAIKEEFINN GVYINNIDNT YYKKENILIM KKILHYFPLL 420
  421 KLIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.221849
Match:	1epwA
Description:	Botulinum neurotoxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.611141034457968	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [425-1127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSDLKKLKK QYLPLLAHEL KIFLFFIVNI TGGHFSSVLS SLEIQLLLLY IFNQPYDNVI  60
   61 YDIGHQAYVH KILTGRKLLF LSLRNKKGIS GFLNIFESIY DKFGAGHSST SLSAIQGYYE 120
  121 AEWQVKNKEK YGNGDIEISD NANVTNNERI FQKGIHNDNN INNNINNNNY INPSDVVGRE 180
  181 NTNVPNVRND NHNVDKVHIA IIGDGGLTGG MALEALNYIS FLNSKILIIY NDNGQVSLPT 240
  241 NAVSISGNRP IGSISDHLHY FVSNIEANAG DNKLSKNAKE NNIFENLNYD YIGVVNGNNT 300
  301 EELFKVLNNI KENKLKRATV LHVRTKKSND FINSKSPISI LHSIKKNEIF PFDTTILNGN 360
  361 IHKENKIEEE KNVSSSTKYD VNNKNNKNND NSEIIKYEDM FSKETFTDIY TNEMLKYLKK 420
  421 DRNIIFLSPA MLGGSGLVKI SERYPNNVYD VGIAEQHSVT FAAAMAMNKK LKIQLCIYST 480
  481 FLQRAYDQII HDLNLQNIPL KVIIGRSGLV GEDGATHQGI YDLSYLGTLN NAYIISPSNQ 540
  541 VDLKRALRFA YLDKDHSVYI RIPRMNILSD KYMKGYLNIH MKNESKNIDV NVDINDDVDK 600
  601 YSEEYMDDDN FIKSFIGKSR IIKMDNENNN TNEHYSSRGD TQTKKKKVCI FNMGSMLFNV 660
  661 INAIKEIEKE QYISHNYSFS IVDMIFLNPL DKNMIDHVIK QNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1itzA
Description:	Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.620868432332651	bayes_pls_golite062009
pyruvate dehydrogenase activity	0.55206250942129	bayes_pls_golite062009
catalytic activity	0.545407789079971	bayes_pls_golite062009
transketolase activity	0.464887205441183	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	0.41381804072744	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.325877250101845	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [1128-1205]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQYLITYEDN TIGGFSTHFN NYLIENNYIT KHNLYVHNIY LSNEPIEHAS FKDQQEVVKM  60
   61 DKCSLVNRIK NYLKNNPT

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.12
Match:	2o1xA
Description:	No description for 2o1xA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: