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View Structure Prediction Details

Protein: gi|9255922
Organism: Plasmodium falciparum
Length: 492 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|9255922.

Description E-value Query
Range
Subject
Range
gi|8050826 - gi|8050826|gb|AAF71757.1| cysteine protease falcipain-3; PCP2 [Plasmodium falciparum]
414.0 [0..5] [492..1]
gi|47606560 - gi|47606560|gb|AAT36264.1| vivapain-2 [Plasmodium vivax]
394.0 [0..1] [492..1]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYHMEYSPN EVIKQEREVF VGKEKSGSKF KRKRSIFIVL TVSICFMFAL MLFYFTRNEN  60
   61 NKTLFTNSLS NNINDDYIIN SLLK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESGKKFIVS KLEELISSYD KEKKMRTTGA EENNMNMNGI DDKDNKSVSF VNKKNGNLKV  60
   61 NNNNQVSYSN LFDTKFLM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.09691
Match: 1k3bA
Description: Dipeptidyl peptidase I (cathepsin C), exclusion domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [163-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLETVNLFY IFLKENNKKY ETSEEMQKRF IIFSENYRKI ELHNKKTNSL YKRGMNKFGD  60
   61 LSPEEFRSKY LNLKTHGPFK TLSPPVSYEA NYED

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.21
Match: 1pciA
Description: Caricain (protease omega)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [257-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIKKYKPADA KLDRIAYDWR LHGGVTPVKD QALCGSCWAF SSVGSVESQY AIRKKALFLF  60
   61 SEQELVDCSV KNNGCYGGYI TNAFDDMIDL GGLCSQDDYP YVSNLPETCN LKRCNERYTI 120
  121 KSYVSIPDDK FKEALRYLGP ISISIAASDD FAFYRGGFYD GECGAAPNHA VILVGYGMKD 180
  181 IYNEDTGRME KFYYYIIKNS WGSDWGEGGY INLETDENGY KKTCSIGTEA YVPLLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.39794
Match: 1yvbA
Description: No description for 1yvbA was found.

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
hydrolase activity 3.74079711298952 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.29265216891074 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.774177093888744 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.649171767629235 bayes_pls_golite062009
thiolester hydrolase activity 0.59115205419466 bayes_pls_golite062009
kininogen binding 0.41283715939055 bayes_pls_golite062009
signal transducer activity 0.12644030784065 bayes_pls_golite062009
molecular transducer activity 0.12644030784065 bayes_pls_golite062009
ubiquitin-specific protease activity 0.0101379718864654 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle