YRC Public Data Repository - Protein Structure Prediction

Protein:	SMC_MYCLE
Organism:	Mycobacterium leprae TN
Length:	1203 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC_MYCLE.

Description	E-value	Query Range	Subject Range
gi\|41397447, gi\|... - gi\|41409088\|ref\|NP_961924.1\| hypothetical protein MAP2990c [Mycobacterium avium subsp. paratuberculo...	340.0	[0..1]	[1200..41]
gi\|120403167, gi... - gi\|90203597\|ref\|ZP_01206242.1\| Chromosome segregation protein SMC [Mycobacterium vanbaalenii PYR-1],...	332.0	[0..1]	[1194..1]
gi\|108798921, gi... - gi\|108798921\|ref\|YP_639118.1\| condensin subunit Smc [Mycobacterium sp. MCS], gi\|108769340\|gb\|ABG0806... gi\|119694125, gi... - gi\|92917438\|ref\|ZP_01286051.1\| Chromosome segregation protein SMC [Mycobacterium sp. KMS], gi\|924384...	325.0	[0..1]	[1194..1]
gi\|7446608 - gi\|7446608\|pir\|\|B70748 probable smc protein - Mycobacterium tuberculosis (strain H37RV) gi\|15610059 - ref\|NP_217438.1\| smc [Mycobacterium tuberculosis H37Rv]	325.0	[0..1]	[1203..85]
gi\|111023487, gi... - gi\|111023487\|ref\|YP_706459.1\| chromosome partition protein [Rhodococcus jostii RHA1], gi\|110823017\|g...	325.0	[0..1]	[1194..1]
gi\|126434521, gi... - gi\|92911035\|ref\|ZP_01279809.1\| Chromosome segregation protein SMC [Mycobacterium sp. JLS], gi\|924314...	324.0	[0..1]	[1194..1]
gi\|66965309, gi\|... - gi\|66965309\|ref\|ZP_00412876.1\| SMC protein, N-terminal:Structural maintenance of chromosome protein ...	316.0	[0..1]	[1190..39]
gi\|121494451, gi... - gi\|121638803\|ref\|YP_979027.1\| putative chromosome partition protein smc [Mycobacterium bovis BCG str... gi\|31619693, gi\|... - gi\|31794098\|ref\|NP_856591.1\| chromosome partition protein Smc [Mycobacterium bovis AF2122/97], gi\|31... gi\|224991295, gi... - gi\|224991295\|ref\|YP_002645984.1\| putative chromosome partition protein [Mycobacterium bovis BCG str....	307.0	[0..1]	[1203..1]
gi\|215431869 - gi\|215431869\|ref\|ZP_03429788.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi... SMC_MYCTO - Chromosome partition protein Smc OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=smc PE... gi\|148662766, gi... - gi\|148662766\|ref\|YP_001284289.1\| putative chromosome segregation SMC protein [Mycobacterium tubercul... SMC_MYCTU - Chromosome partition protein Smc OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=smc PE... SMC_MYCTU - Chromosome partition protein Smc OS=Mycobacterium tuberculosis GN=smc PE=3 SV=2 gi\|254233012, gi... - gi\|81252985\|ref\|ZP_00877553.1\| COG1196: Chromosome segregation ATPases [Mycobacterium tuberculosis C... gi\|215412764 - gi\|215412764\|ref\|ZP_03421476.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi... gi\|215404897 - gi\|215404897\|ref\|ZP_03417078.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi...	304.0	[0..1]	[1203..1]
gi\|254551995 - gi\|254551995\|ref\|ZP_05142442.1\| chromosome partition protein smc [Mycobacterium tuberculosis '98-R60... gi\|253797990, gi... - gi\|253797990\|ref\|YP_003030991.1\| chromosome partition protein smc [Mycobacterium tuberculosis KZN 14... gi\|255097752 - gi\|255097752\|ref\|ZP_05327230.1\| chromosome partitioning protein smc [Mycobacterium tuberculosis KZN ... gi\|148722638, gi... - gi\|76783398\|ref\|ZP_00770590.1\| COG1196: Chromosome segregation ATPases [Mycobacterium tuberculosis F...	304.0	[0..1]	[1203..1]

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Predicted Domain #1

Region A:
Residues: [1-165]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLKSLTLKG FKSFASPTTL RFEPGITAVV GPNGSGKSNV VDALAWVMGE QGAKTLRGSK  60
   61 MEDVIFAGTL SRAPLGRAEV TLIIDNSDNV LPIEYSEVSI TRRMFRDGAS EYEINGSSCR 120
  121 LMDVQELLSD SGIGREMHVI VGQGKLDQIL QSRPEDRRTF IEEAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.221849
Match:	1xewX
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.470983068319171	bayes_pls_golite062009
hydrolase activity	0.0582794297634999	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [166-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GILKYRRRKE KALRKLDAMS ANLARLTDLT TELRRQLKPL SRQAEVARRA ATIQADLRDA  60
   61 RLRLAADDLV SRQGQRDAIV EAETMMRRDH DEAAARLAVA SEELAAHEAA LTELSGRAES 120
  121 VQQIWFGLST LVERVSATIR IAGERAYHLD VDPATPSDTD PDVLEAEAQQ MEVAEQQLLA 180
  181 ELAVARTQLE AARAELADRE RHAVEADKAH LEAVRAEADR REGLALLAGQ VETMRARIES 240
  241 IDDSVARLSE RIEEVTARTQ QILAEFETVQ GRVGELDQSE VHLDEQHERA VAALRFANER 300
  301 VAELQSAERD AERQVVSLRA RIDALTMGLE RKDGA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.99
Match:	1c1gA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [501-697]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AWLARNYSDT GLLGSIAKLV KVRPGYEAAL AAVLGPAADA LAVDSLGAAR SALTALKEAD  60
   61 AGRATLVLAD WLADAGPACV TGLPDGAQRA LDLIEAPPWL QGALIAMLYG VVVVNYLAEA 120
  121 LGVVDICPQL RVVTVDGDLV GAGWVSGGSG RRLSTLEVTS EIDKAGAELA AAEAHMAQLN 180
  181 AALSGALSEQ VAHSDAT

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.86
Match:	1gxlA
Description:	Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.225375777463061	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [698-918]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQALVALNES DTAILSMYDQ LGRLGQEVRA AEAEWESLLA QREELEARRV SILEEVVELE  60
   61 TRLHNVEQIQ HVHALDENSA AARQLIVAAA EEARGVEVEA LLAVRTAEER VNAVCGRANS 120
  121 LRRAAAAERE VRLRDQQAHA ARIRAAAVAA AVTDCGQLLA SRLTQAVDLA ARHRDALATE 180
  181 RQQRSVAIAA VRYEVNTLRV RLATLTDSLH RDEVANVQAA L

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [919-1046]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIEQLEQLVL EQFGIAPVDL IAEYGPQVAL LPTELEMAEF QQARERGEQV TSPAPMPYDR  60
   61 ATQERRAKRA ERELAELGRV NPLALEEFAA LEERYNFLST QLEDVKGARK DLLDVVAEVD 120
  121 ARILQVFS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1047-1203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAFVDVEREF RGVFTSLFPG GEGRLRLTDP DDMLTTGIEV EARPSGKKVS RLSLLSGGEK  60
   61 SLIAVAMLVA IFKARPSPFY IMDEVEAALD DVNLCRLIGV FEQLRGQSQL IIITHQKPTM 120
  121 EVADTLYGVT MQGDGITAVI SQRMRGQQVE SLVTSSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.221849
Match:	1xewY
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: