YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25290765
Organism:	Streptococcus pneumoniae
Length:	763 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25290765.

Description	E-value	Query Range	Subject Range
gi\|116076290, gi... - gi\|116515714\|ref\|YP_816449.1\| ATP-dependent DNA helicase PcrA [Streptococcus pneumoniae D39], gi\|116... gi\|25290772 - pir\|\|C97996 ATP-dependent DNA helicase (EC 3.6.1.-) [imported] - Streptococcus pneumoniae (strain R6... gi\|15458610, gi\|... - gi\|15903039\|ref\|NP_358589.1\| ATP-dependent DNA helicase PcrA [Streptococcus pneumoniae R6], gi\|15458...	691.0	[0..1]	[763..1]
gi\|77174333, gi\|... - gi\|77407064\|ref\|ZP_00784070.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae H36B], gi\|7... gi\|76787976, gi\|... - gi\|76787976\|ref\|YP_329845.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae A909], gi\|765... gi\|77413012, gi\|... - gi\|77413012\|ref\|ZP_00789214.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae 515], gi\|77...	645.0	[0..1]	[762..1]
gi\|77409591, gi\|... - gi\|77409591\|ref\|ZP_00786269.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae COH1], gi\|7...	645.0	[0..1]	[762..1]
gi\|25011258, gi\|... - gi\|25011258\|ref\|NP_735653.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae NEM316], gi\|2...	645.0	[0..1]	[762..1]
gi\|22537300, gi\|... - gi\|22537300\|ref\|NP_688151.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae 2603V/R], gi\|...	644.0	[0..1]	[762..1]
gi\|77412397, gi\|... - gi\|77412397\|ref\|ZP_00788706.1\| ATP-dependent DNA helicase PcrA [Streptococcus agalactiae CJB111], gi...	644.0	[0..1]	[762..1]
gi\|94994523, gi\|... - gi\|94994523\|ref\|YP_602621.1\| DNA helicase II [Streptococcus pyogenes MGAS10750], gi\|94548031\|gb\|ABF3...	644.0	[0..1]	[762..1]
gi\|134271913, gi... - gi\|139473666\|ref\|YP_001128382.1\| DNA helicase II [Streptococcus pyogenes str. Manfredo], gi\|13427191... gi\|71903614, gi\|... - gi\|71903614\|ref\|YP_280417.1\| DNA helicase II [Streptococcus pyogenes MGAS6180], gi\|71802709\|gb\|AAX72...	644.0	[0..1]	[762..1]
gi\|19746195, gi\|... - gi\|19748377\|gb\|AAL97830.1\| putative ATP-dependent DNA helicase [Streptococcus pyogenes MGAS8232], gi...	643.0	[0..1]	[762..1]
gi\|94992533, gi\|... - gi\|94992533\|ref\|YP_600632.1\| DNA helicase II [Streptococcus pyogenes MGAS2096], gi\|94546041\|gb\|ABF36... gi\|21904635, gi\|... - gi\|21910437\|ref\|NP_664705.1\| DNA helicase II [Streptococcus pyogenes MGAS315], gi\|21904635\|gb\|AAM795... gi\|94988710, gi\|... - gi\|94988710\|ref\|YP_596811.1\| DNA helicase II [Streptococcus pyogenes MGAS9429], gi\|94542218\|gb\|ABF32... gi\|71910790, gi\|... - gi\|71910790\|ref\|YP_282340.1\| DNA helicase II [Streptococcus pyogenes MGAS5005], gi\|71853572\|gb\|AAZ51... gi\|28896013, gi\|... - gi\|28896013\|ref\|NP_802363.1\| DNA helicase II [Streptococcus pyogenes SSI-1], gi\|28811263\|dbj\|BAC6419... gi\|13622394, gi\|... - gi\|15675225\|ref\|NP_269399.1\| DNA helicase II [Streptococcus pyogenes M1 GAS], gi\|13622394\|gb\|AAK3412...	643.0	[0..1]	[762..1]

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Predicted Domain #1

Region A:
Residues: [1-763]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNALLNGMND RQAEAVQTTE GPLLIMAGAG SGKTRVLTHR IAYLIDEKLV NPWNILAITF  60
   61 TNKAAREMKE RAYSLNPATQ DCLIATFHSM CVRILRRDAD HIGYNRNFTI VDPGEQRTLM 120
  121 KRILKQLNLD PKKWNERTIL GTISNAKNDL IDDVAYAAQA GDMYTQIVAQ CYTAYQKELR 180
  181 QSESVDFDDL IMLTLRLFDQ NPDVLTYYQQ KFQYIHVDEY QDTNHAQYQL VKLLASRFKN 240
  241 ICVVGDADQS IYGWRGADMQ NILDFEKDYP KAKVVLLEEN YRSTKTILQA ANEVIKNNKN 300
  301 RRPKNLWTQN ADGEQIVYYR ADDELDEAVF VARTIDELSR SQNFLHKDFA VLYRTNAQSR 360
  361 TIEEALLKSN IPYTMVGGTK FYSRKEIRDI IAYLNLIANL SDNISFERII NEPKRGIGLG 420
  421 TVEKIRDFAN LQNMSMLDAS ANIMLSGIKG KAAQSIWDFA NMMLDLREQL DHLSITELVE 480
  481 SVLEKTGYVD ILNSQATLES KARVENIEEF LSVTKNFDDT TDVTEEETGL DKLSRFLNDL 540
  541 ALIADTDSGS QETSEVTLMT LHAAKGLEFP VVFLIGMEEN VFPLSRATED SDELEEERRL 600
  601 AYVGITRAEK ILYLTNANSR LLFGRTNYNR PTRFINEISS DLLEYQGLAR PANTSFKASY 660
  661 SSGSISFGQG MSLAQALQDR KRGAAPKSIQ SSGLPFGQFT AGAKPASSEA NWSIGDIALH 720
  721 KKWGEGTVLE VSGSGARQEL KINFPEVGLK KLLASVAPIE KKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	170.0
Match:	1pjrA
Description:	STRUCTURE OF DNA HELICASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.0681607836408	bayes_pls_golite062009
pyrophosphatase activity	1.81138802583782	bayes_pls_golite062009
helicase activity	1.40781177352978	bayes_pls_golite062009
DNA-dependent ATPase activity	1.09000822067541	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.00391607739958	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.913322399315129	bayes_pls_golite062009
DNA clamp loader activity	0.91290128595235	bayes_pls_golite062009
DNA helicase activity	0.86836375892673	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.5607032154839	bayes_pls_golite062009
ATP-dependent helicase activity	0.5607032154839	bayes_pls_golite062009
structure-specific DNA binding	0.541554702463666	bayes_pls_golite062009
motor activity	0.50661339105747	bayes_pls_golite062009
transcription regulator activity	0.390949264169589	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
DNA binding	0.376487324624615	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.133736530545575	bayes_pls_golite062009
double-stranded DNA binding	0.11598665103566	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
DNA polymerase activity	4.95561462330096E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: