YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|119612942, gi...
Organism:	Homo sapiens
Length:	875 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119612942, gi....

Description	E-value	Query Range	Subject Range
gi\|20521650 - gi\|20521650\|dbj\|BAA34490.2\| KIAA0770 protein [Homo sapiens]	0.0	[1..875]	[39..913]
gi\|197102898 - gi\|197102898\|ref\|NP_001125801.1\| vacuolar protein sorting 39 homolog [Pongo abelii] gi\|55729243 - gi\|55729243\|emb\|CAH91357.1\| hypothetical protein [Pongo abelii]	0.0	[1..875]	[1..875]
gi\|109080747 - gi\|109080747\|ref\|XP_001103143.1\| PREDICTED: vacuolar protein sorting 39 (yeast) isoform 2 [Macaca mu...	0.0	[1..875]	[1..875]
gi\|76627233 - gi\|76627233\|ref\|XP_873577.1\| PREDICTED: similar to vacuolar protein sorting 39 isoform 2 [Bos taurus...	0.0	[1..875]	[1..875]
gi\|62645638, gi\|... - gi\|62645638\|ref\|XP_575216.1\| PREDICTED: similar to vacuolar protein sorting 39 isoform 2 [Rattus nor...	0.0	[1..875]	[1..875]
gi\|73999819 - gi\|73999819\|ref\|XP_544640.2\| PREDICTED: similar to vacuolar protein sorting 39 isoform 2 [Canis fami...	0.0	[1..875]	[1..875]
gi\|57977132, gi\|... - gi\|74221407\|dbj\|BAE42179.1\| unnamed protein product [Mus musculus], gi\|57977132\|dbj\|BAD88411.1\| mVAM...	0.0	[1..875]	[1..875]
gi\|114656568 - gi\|114656568\|ref\|XP_510331.2\| PREDICTED: vacuolar protein sorting 39 [Pan troglodytes]	0.0	[1..875]	[1..886]

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Predicted Domain #1

Region A:
Residues: [1-212]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDAFEPVPI LEKLPLQIDC LAAWEEWLLV GTKQGHLLLY RIRKDVGCNR FEVTLEKSNK  60
   61 NFSKKIQQIH VVSQFKILVS LLENNIYVHD LLTFQQITTV SKAKGASLFT CDLQHTETGE 120
  121 EVLRMCVAVK KKLQLYFWKD REFHELQGDF SVPDVPKSMA WCENSICVGF KRDYYLIRVD 180
  181 GKGSIKELFP TGKQLEPLVA PLADGKVAVG QD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.92
Match:	1erjA
Description:	Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.38386546684697	bayes_pls_golite062009
transcription regulator activity	2.36560618519891	bayes_pls_golite062009
nucleic acid binding	1.99673640585547	bayes_pls_golite062009
DNA binding	1.74970945772818	bayes_pls_golite062009
transporter activity	1.23232041140488	bayes_pls_golite062009
protein binding	1.14503622489775	bayes_pls_golite062009
transcription factor activity	1.10790917305704	bayes_pls_golite062009
receptor activity	0.985978971632527	bayes_pls_golite062009
signal transducer activity	0.786039867308269	bayes_pls_golite062009
molecular transducer activity	0.786039867308269	bayes_pls_golite062009
substrate-specific transporter activity	0.750051725890322	bayes_pls_golite062009
transcription repressor activity	0.561205988591905	bayes_pls_golite062009
transcription factor binding	0.421428497325728	bayes_pls_golite062009
hydrolase activity	0.346903609858078	bayes_pls_golite062009
cytoskeletal protein binding	0.271959658140432	bayes_pls_golite062009
transcription cofactor activity	0.203779337313278	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0245411309982146	bayes_pls_golite062009
transcription corepressor activity	0.00328955300255629	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [213-875]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLTVVLNEEG ICTQKCALNW TDIPVAMEHQ PPYIIAVLPR YVEIRTFEPR LLVQSIELQR  60
   61 PRFITSGGSN IIYVASNHFV WRLIPVPMAT QIQQLLQDKQ FELALQLAEM KDDSDSEKQQ 120
  121 QIHHIKNLYA FNLFCQKRFD ESMQVFAKLG TDPTHVMGLY PDLLPTDYRK QLQYPNPLPV 180
  181 LSGAELEKAH LALIDYLTQK RSQLVKKLND SDHQSSTSPL MEGTPTIKSK KKLLQIIDTT 240
  241 LLKCYLHTNV ALVAPLLRLE NNHCHIEESE HVLKKAHKYS ELIILYEKKG LHEKALQVLV 300
  301 DQSKKANSPL KGHERTVQYL QHLGTENLHL IFSYSVWVLR DFPEDGLKIF TEDLPEVESL 360
  361 PRDRVLGFLI ENFKGLAIPY LEHIIHVWEE TGSRFHNCLI QLYCEKVQGL MKEYLLSFPA 420
  421 GKTPVPAGEE EGELGEYRQK LLMFLEISSY YDPGRLICDF PFDGLLEERA LLLGRMGKHE 480
  481 QALFIYVHIL KDTRMAEEYC HKHYDRNKDG NKDVYLSLLR MYLSPPSIHC LGPIKLELLE 540
  541 PKANLQAALQ VLELHHSKLD TTKALNLLPA NTQINDIRIF LEKVLEENAQ KKRFNQVLKN 600
  601 LLHAEFLRVQ EERILHQQVK CIITEEKVCM VCKKKIGNSA FARYPNGVVV HYFCSKEVNP 660
  661 ADT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.30103
Match:	1xi4A
Description:	Clathrin D6 Coat
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: