YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7446608
Organism:	Mycobacterium tuberculosis
Length:	1289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7446608.

Description	E-value	Query Range	Subject Range
gi\|221230335, gi... - gi\|221230335\|ref\|YP_002503751.1\| putative cell division protein [Mycobacterium leprae Br4923], gi\|21... SMC_MYCLE - Chromosome partition protein Smc OS=Mycobacterium leprae GN=smc PE=3 SV=1 SMC_MYCLE - Chromosome partition protein Smc OS=Mycobacterium leprae (strain TN) GN=smc PE=3 SV=1	374.0	[0..85]	[1289..1]
gi\|41397447, gi\|... - gi\|41409088\|ref\|NP_961924.1\| hypothetical protein MAP2990c [Mycobacterium avium subsp. paratuberculo...	373.0	[0..83]	[1286..39]
gi\|121494451, gi... - gi\|121638803\|ref\|YP_979027.1\| putative chromosome partition protein smc [Mycobacterium bovis BCG str... gi\|31619693, gi\|... - gi\|31794098\|ref\|NP_856591.1\| chromosome partition protein Smc [Mycobacterium bovis AF2122/97], gi\|31... gi\|224991295, gi... - gi\|224991295\|ref\|YP_002645984.1\| putative chromosome partition protein [Mycobacterium bovis BCG str....	362.0	[0..85]	[1289..1]
gi\|254551995 - gi\|254551995\|ref\|ZP_05142442.1\| chromosome partition protein smc [Mycobacterium tuberculosis '98-R60... gi\|253797990, gi... - gi\|253797990\|ref\|YP_003030991.1\| chromosome partition protein smc [Mycobacterium tuberculosis KZN 14... gi\|255097752 - gi\|255097752\|ref\|ZP_05327230.1\| chromosome partitioning protein smc [Mycobacterium tuberculosis KZN ... gi\|148722638, gi... - gi\|76783398\|ref\|ZP_00770590.1\| COG1196: Chromosome segregation ATPases [Mycobacterium tuberculosis F...	360.0	[0..85]	[1289..1]
gi\|215431869 - gi\|215431869\|ref\|ZP_03429788.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi... SMC_MYCTO - Chromosome partition protein Smc OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=smc PE... gi\|148662766, gi... - gi\|148662766\|ref\|YP_001284289.1\| putative chromosome segregation SMC protein [Mycobacterium tubercul... SMC_MYCTU - Chromosome partition protein Smc OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=smc PE... SMC_MYCTU - Chromosome partition protein Smc OS=Mycobacterium tuberculosis GN=smc PE=3 SV=2 gi\|254233012, gi... - gi\|81252985\|ref\|ZP_00877553.1\| COG1196: Chromosome segregation ATPases [Mycobacterium tuberculosis C... gi\|215412764 - gi\|215412764\|ref\|ZP_03421476.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi... gi\|215404897 - gi\|215404897\|ref\|ZP_03417078.1\| putative chromosome partition protein smc [Mycobacterium tuberculosi...	360.0	[0..85]	[1289..1]
gi\|120403167, gi... - gi\|90203597\|ref\|ZP_01206242.1\| Chromosome segregation protein SMC [Mycobacterium vanbaalenii PYR-1],...	358.0	[0..85]	[1289..1]
gi\|108798921, gi... - gi\|108798921\|ref\|YP_639118.1\| condensin subunit Smc [Mycobacterium sp. MCS], gi\|108769340\|gb\|ABG0806... gi\|119694125, gi... - gi\|92917438\|ref\|ZP_01286051.1\| Chromosome segregation protein SMC [Mycobacterium sp. KMS], gi\|924384...	352.0	[0..85]	[1285..1]
gi\|126434521, gi... - gi\|92911035\|ref\|ZP_01279809.1\| Chromosome segregation protein SMC [Mycobacterium sp. JLS], gi\|924314...	352.0	[0..85]	[1285..1]
gi\|111023487, gi... - gi\|111023487\|ref\|YP_706459.1\| chromosome partition protein [Rhodococcus jostii RHA1], gi\|110823017\|g...	345.0	[0..85]	[1281..1]
gi\|66965309, gi\|... - gi\|66965309\|ref\|ZP_00412876.1\| SMC protein, N-terminal:Structural maintenance of chromosome protein ...	329.0	[0..79]	[1276..33]

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Predicted Domain #1

Region A:
Residues: [1-83]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAGSRFPLV DPLPSVGARP DRLRGQPRRR TRAGGRPGSA RCVPEAAAAA AGRHDTGPRR  60
   61 QSRRRLVAVD GADHRVQRAV IWP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [84-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVYLKSLTLK GFKSFAAPTT LRFEPGITAV VGPNGSGKSN VVDALAWVMG EQGAKTLRGG  60
   61 KMEDVIFAGT SSRAPLGRAE VTVSIDNSDN ALPIEYTEVS ITRRMFRDGA SEYEINGSSC 120
  121 RLMDVQELLS DSGIGREMHV IVGQGKLEEI LQSRPEDRRA FIEEAAGVLK HRKRKEKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	1xewX
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.470983068319171	bayes_pls_golite062009
hydrolase activity	0.0582794297634999	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [262-588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRKLDTMAAN LARLTDLTTE LRRQLKPLGR QAEAAQRAAA IQADLRDARL RLAADDLVSR  60
   61 RAEREAVFQA EAAMRREHDE AAARLAVASE ELAAHESAVA ELSTRAESIQ HTWFGLSALA 120
  121 ERVDATVRIA SERAHHLDIE PVAVSDTDPR KPEELEAEAQ QVAVAEQQLL AELDAARARL 180
  181 DAARAELADR ERRAAEADRA HLAAVREEAD RREGLARLAG QVETMRARVE SIDESVARLS 240
  241 ERIEDAAMRA QQTRAEFETV QGRIGELDQG EVGLDEHHER TVAALRLADE RVAELQSAER 300
  301 AAERQVASLR ARIDALAVGL QRKDGAA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.2
Match:	1c1gA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [589-775]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WLAHNRSGAG LFGSIAQLVK VRSGYEAALA AALGPAADAL AVDGLTAAGS AVSALKQADG  60
   61 GRAVLVLSDW PAPQAPQSAS GEMLPSGAQW ALDLVESPPQ LVGAMIAMLS GVAVVNDLTE 120
  121 AMGLVEIRPE LRAVTVDGDL VGAGWVSGGS DRKLSTLEVT SEIDKARSEL AAAEALAAQL 180
  181 NAALAGA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.9
Match:	1gxlA
Description:	Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.225375777463061	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [776-1020]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEQSARQDA AEQALAALNE SDTAISAMYE QLGRLGQEAR AAEEEWNRLL QQRTEQEAVR  60
   61 TQTLDDVIQL ETQLRKAQET QRVQVAQPID RQAISAAADR ARGVEVEARL AVRTAEERAN 120
  121 AVRGRADSLR RAAAAEREAR VRAQQARAAR LHAAAVAAAV ADCGRLLAGR LHRAVDGASQ 180
  181 LRDASAAQRQ QRLAAMAAVR DEVNTLSARV GELTDSLHRD ELANAQAALR IEQLEQMVLE 240
  241 QFGMA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1021-1127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PADLITEYGP HVALPPTELE MAEFEQARER GEQVIAPAPM PFDRVTQERR AKRAERALAE  60
   61 LGRVNPLALE EFAALEERYN FLSTQLEDVK AARKDLLGVV ADVDARI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1128-1289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQVFNDAFVD VEREFRGVFT ALFPGGEGRL RLTEPDDMLT TGIEVEARPP GKKITRLSLL  60
   61 SGGEKALTAV AMLVAIFRAR PSPFYIMDEV EAALDDVNLR RLLSLFEQLR EQSQIIIITH 120
  121 QKPTMEVADA LYGVTMQNDG ITAVISQRMR GQQVDQLVTN SS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.154902
Match:	1xewY
Description:	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: