YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30258687, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30258687, gi|....

Description	E-value	Query Range	Subject Range
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	0.0	[1..418]	[1..408]
gi\|18157428 - gi\|18157428\|dbj\|BAB83769.1\| dihydrolipoyl acetyltransferase [Geobacillus stearothermophilus]	0.0	[1..419]	[1..434]
gi\|56419595, gi\|... - gi\|56419595\|ref\|YP_146913.1\| branched-chain alpha-keto acid dehydrogenase subunit E2 [Geobacillus ka...	0.0	[1..419]	[1..434]
gi\|53732513 - gi\|53732513\|ref\|ZP_00154561.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|48868188, gi\|... - gi\|68250263\|ref\|YP_249375.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydr...	0.0	[1..418]	[1..408]
gi\|88811363, gi\|... - gi\|88811363\|ref\|ZP_01126618.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyl...	0.0	[1..418]	[1..442]
ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	0.0	[1..418]	[1..408]
gi\|90438940, gi\|... - gi\|90580055\|ref\|ZP_01235863.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438940...	0.0	[1..418]	[1..400]
gi\|144982919 - gi\|144982919\|gb\|EDJ90432.1\| carboxy-terminal protease [Haemophilus influenzae R3021] gi\|145639183, gi... - gi\|145639183\|ref\|ZP_01794790.1\| carboxy-terminal protease [Haemophilus influenzae PittII], gi\|145271... gi\|145631489 - gi\|145631489\|ref\|ZP_01787258.1\| carboxy-terminal protease [Haemophilus influenzae 22.4-21] gi\|46133588 - gi\|46133588\|ref\|ZP_00157429.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..418]	[1..408]
gi\|89073521, gi\|... - gi\|89073521\|ref\|ZP_01160044.1\| dihydrolipoamide acetyltransferase [Photobacterium sp. SKA34], gi\|890...	0.0	[1..418]	[1..400]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFEFKLPDI GEGIHEGEIV KWFIKPGDEV NEDDVLLEVQ NDKAVVEIPS PVKGKVLEVL  60
   61 VEEGTVAVVG DTLIKFDAPG YE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.221849
Match:	1labA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE LIPOYL DOMAIN FROM BACILLUS STEAROTHERMOPHILUS PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.83081843426182	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
acyltransferase activity	2.79754636323803	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
binding	0.750493230403211	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
protein binding	0.396415237274882	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [83-182]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLKFKGDDHD EAPKAEATPA ATAEVVNERV IAMPSVRKYA RENGVDIHKV AGSGKNGRIV  60
   61 KADIDAFANG GQAVAATEAP AAVEATPAAA KEEAPKAQPI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.28
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [183-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAGEYPETRE KMSGIRKAIA KAMVNSKHTA PHVTLMDEVD VTELVAHRKK FKAVAADKGI  60
   61 KLTYLPYVVK ALTSALREYP MLNTSLDDAS QEVVHKHYFN IGIAADTDKG LLVPVVKDTD 120
  121 RKSIFTISNE INDLAGKARE GRLAPAEMKG ASCTITNIGS AGGQWFTPVI NHPEVAILGI 180
  181 GRIAEKPVVK NGEIVAAPVL ALSLSFDHRL IDGATAQKAL NQIKRLLNDP QLLVMEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.69897
Match:	1b5sA
Description:	Dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.56278653179232	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.127298422545208	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: