YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30263077, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	377 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30263077, gi|....

Description	E-value	Query Range	Subject Range
gi\|228901635, gi... - gi\|228901635\|ref\|ZP_04065812.1\| Zinc-type alcohol dehydrogenase [Bacillus thuringiensis IBL 4222], g... gi\|218898181, gi... - gi\|218898181\|ref\|YP_002446592.1\| oxidoreductase, zinc-binding dehydrogenase family [Bacillus cereus ... gi\|74487704, gi\|... - gi\|75764807\|ref\|ZP_00744190.1\| Glutathione-dependent formaldehyde dehydrogenase [Bacillus thuringien...	1.0E-97	[1..377]	[1..377]
gi\|47564250, gi\|... - gi\|47564250\|ref\|ZP_00235295.1\| glutathione-dependent formaldehyde dehydrogenase [Bacillus cereus G92...	2.0E-97	[1..377]	[1..377]
gi\|52142404, gi\|... - gi\|52142404\|ref\|YP_084425.1\| alcohol dehydrogenase, glutathione-dependent formaldehyde dehydrogenase...	2.0E-97	[1..377]	[1..377]
gi\|228655012, gi... - gi\|229128429\|ref\|ZP_04257409.1\| Zinc-type alcohol dehydrogenase [Bacillus cereus BDRD-Cer4], gi\|2286... gi\|29896758, gi\|... - gi\|30021204\|ref\|NP_832835.1\| glutathione-dependent formaldehyde dehydrogenase [Bacillus cereus ATCC ...	2.0E-97	[1..377]	[1..377]
gi\|56379315, gi\|... - gi\|56419473\|ref\|YP_146791.1\| alcohol dehydrogenase [Geobacillus kaustophilus HTA426], gi\|56379315\|db...	3.0E-97	[1..377]	[1..378]
gi\|186468718, gi... - gi\|23126690\|ref\|ZP_00108579.1\| COG1063: Threonine dehydrogenase and related Zn-dependent dehydrogena...	3.0E-97	[1..377]	[1..389]
gi\|75910697, gi\|... - gi\|75910697\|ref\|YP_324993.1\| zinc-containing alcohol dehydrogenase superfamily protein [Anabaena var...	2.0E-96	[1..377]	[1..389]
gi\|17228392, gi\|... - gi\|17228392\|ref\|NP_484940.1\| alcohol dehydrogenase [Nostoc sp. PCC 7120], gi\|17130243\|dbj\|BAB72854.1... gi\|25283024 - pir\|\|AF1918 alcohol dehydrogenase [imported] - Nostoc sp. (strain PCC 7120)	2.0E-96	[1..377]	[1..389]
gi\|42738125, gi\|... - gi\|42782200\|ref\|NP_979447.1\| alcohol dehydrogenase, zinc-containing [Bacillus cereus ATCC 10987], gi...	3.0E-96	[1..377]	[1..377]
gi\|49333308, gi\|... - gi\|49481752\|ref\|YP_037205.1\| alcohol dehydrogenase, glutathione-dependent formaldehyde dehydrogenase...	4.0E-96	[1..377]	[1..377]

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Predicted Domain #1

Region A:
Residues: [1-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAVTYQGPN QVQVKQVDDA KLEKKDDIIV KITSTAICGS DLHLYQGNMP LPQGYIIGHE  60
   61 PMGIVEEVGP DVTKVKKGDR VVIPFNVACG HCFYCQHEME SQCDNSNPHY DSGGYFGYTE 120
  121 KFGNHPGGQV EYLKVPFGNF TPFVIPESCE LEDESLLFLS DVLPTAYWSV INAGVKPGDT 180
  181 VIVLGCGPVG LMTQKFAWMH GAKRVIAVDY LDYRINYAKK INNVEVFEFT KFPDMGEHLK 240
  241 EITHGGADVV IDCVGMDGKK SPLEFLEQKL KLQGGTLGPI QIATKAVRKY GTVQMTGVYG 300
  301 GNYNAFPLGA FWVRNINLKM GQAPVIHFMP ELFEKITNKE FDPKEIITHK IPLEEASYGY 360
  361 QIFNNREDDC IKVILKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.0
Match:	1hdyA
Description:	Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	2.58673703881996	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
retinoid binding	1.54383322726845	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
isoprenoid binding	1.42961392805059	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.29842732066898	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.527946013169731	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.484089941059577	bayes_pls_golite062009
kinase activity	0.461063813999598	bayes_pls_golite062009
hydrolase activity	0.41684292392606	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.375415252607746	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.361275519814065	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
protein kinase activity	0.339420053437627	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.298691872199351	bayes_pls_golite062009
nucleic acid binding	0.274019118261823	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
DNA binding	0.164288600669795	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: