YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30262748, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	332 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30262748, gi|....

Description	E-value	Query Range	Subject Range
gi\|65320075 - gi\|65320075\|ref\|ZP_00393034.1\| COG1071: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase...	8.0E-77	[1..332]	[10..341]
gi\|52142736, gi\|... - gi\|52142736\|ref\|YP_084094.1\| acetoin dehydrogenase (TPP-dependent) E1 component alpha subunit [Bacil...	2.0E-76	[1..332]	[1..332]
gi\|42737785, gi\|... - gi\|42781861\|ref\|NP_979108.1\| TPP-dependent acetoin dehydrogenase E1 alpha-subunit [Bacillus cereus A...	2.0E-76	[1..332]	[1..332]
gi\|163940524, gi... - gi\|89207403\|ref\|ZP_01185945.1\| Pyruvate dehydrogenase (lipoamide) [Bacillus weihenstephanensis KBAB4...	1.0E-75	[1..332]	[1..332]
gi\|66267554, gi\|... - gi\|66267554\|gb\|AAH94760.1\| PDHA2 protein [Homo sapiens], gi\|34192185\|gb\|AAH30697.2\| PDHA2 protein [H...	2.0E-75	[1..330]	[62..388]
gi\|55622948 - gi\|55622948\|ref\|XP_526637.1\| PREDICTED: pyruvate dehydrogenase (lipoamide) alpha 2 [Pan troglodytes]	2.0E-75	[1..330]	[96..422]
gi\|49329410, gi\|... - gi\|49477854\|ref\|YP_036865.1\| acetoin dehydrogenase (TPP-dependent) E1 component alpha subunit [Bacil...	2.0E-75	[1..332]	[1..332]
gi\|47554308, gi\|... - gi\|47569039\|ref\|ZP_00239729.1\| acetoin dehydrogenase, alpha subunit [Bacillus cereus G9241], gi\|4755...	3.0E-75	[1..332]	[1..332]
gi\|88599098, gi\|... - gi\|88657641\|ref\|YP_507043.1\| pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase al... gi\|68171461, gi\|... - gi\|68171461\|ref\|ZP_00544848.1\| Pyruvate dehydrogenase (lipoamide) [Ehrlichia chaffeensis str. Sapulp...	3.0E-75	[8..330]	[5..327]

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Predicted Domain #1

Region A:
Residues: [1-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKTTESKEN EITKEQARWM YEKMLEIRKF EDKVHELFAQ GVLPGFVHLY AGEEAVAVGV  60
   61 CAHLTDSDSI TSTHRGHGHC IAKGCDLNGM MAELFGKATG LCKGKGGSMH IADLDKGMLG 120
  121 ANGIVGGGFP LACGSALTAK YKGTKDVSVC FFGDGANNEG TFHEGVNLAA IWKLPVIFIA 180
  181 ENNGYGEATT FEYASSCDSI ADRAKAYNIP GVQVDGKDLL AVYKAAEEAV ERARNGDGPT 240
  241 IIECMTYRNY GHFEGEAQTY KTSEEKEEHL NEKDAIVNFR KHLIHEALLT ESELVDMEKA 300
  301 VDEAVQKSIE FSENSPYPED EELLKDVYVS YK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	71.045757
Match:	1ni4A
Description:	E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	2.61614462349133	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.53492491341322	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: