YRC Public Data Repository - Protein Structure Prediction

Protein:	LEPA_LISMF
Organism:	Listeria monocytogenes serotype 4b str. F2365
Length:	608 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEPA_LISMF.

Description	E-value	Query Range	Subject Range
LEPA_GEOKA - Elongation factor 4 OS=Geobacillus kaustophilus GN=lepA PE=3 SV=1 LEPA_GEOKA - Elongation factor 4 OS=Geobacillus kaustophilus (strain HTA426) GN=lepA PE=3 SV=1	550.0	[0..1]	[608..1]
gi\|153196258, gi... - gi\|254829762\|ref\|ZP_05234417.1\| GTP-binding protein LepA [Listeria monocytogenes 10403S], gi\|1531962... gi\|126943486, gi... - gi\|254898355\|ref\|ZP_05258279.1\| GTP-binding protein LepA [Listeria monocytogenes J0161], gi\|15318383... gi\|153179529, gi... - gi\|254936481\|ref\|ZP_05268178.1\| GTP-binding protein LepA [Listeria monocytogenes F6900], gi\|15317952... gi\|153190922, gi... - gi\|254912153\|ref\|ZP_05262165.1\| GTP-binding protein LepA [Listeria monocytogenes J2818], gi\|15319092... gi\|47095432, gi\|... - gi\|47095432\|ref\|ZP_00233042.1\| GTP-binding protein LepA [Listeria monocytogenes str. 1/2a F6854], gi...	536.0	[0..1]	[608..1]
LEPA_BACHD - Elongation factor 4 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 /... LEPA_BACHD - Elongation factor 4 OS=Bacillus halodurans GN=lepA PE=3 SV=1	535.0	[0..1]	[608..1]
gi\|229157933, gi... - gi\|229157933\|ref\|ZP_04286006.1\| GTP-binding protein lepA [Bacillus cereus ATCC 4342], gi\|228625541\|g... gi\|228987570, gi... - gi\|228987570\|ref\|ZP_04147688.1\| GTP-binding protein lepA [Bacillus thuringiensis serovar tochigiensi... gi\|47553986, gi\|... - gi\|47569315\|ref\|ZP_00239999.1\| GTP-binding protein LepA [Bacillus cereus G9241], gi\|47553986\|gb\|EAL1...	534.0	[0..1]	[607..1]
gi\|254757772 - gi\|254757772\|ref\|ZP_05209799.1\| GTP-binding protein LepA [Bacillus anthracis str. Australia 94] gi\|190562059, gi... - gi\|190567068\|ref\|ZP_03019984.1\| GTP-binding protein LepA [Bacillus anthracis Tsiankovskii-I], gi\|190... gi\|254750900 - gi\|254750900\|ref\|ZP_05202939.1\| GTP-binding protein LepA [Bacillus anthracis str. Vollum] gi\|172081533, gi... - gi\|177653251\|ref\|ZP_02935503.1\| GTP-binding protein LepA [Bacillus anthracis str. A0174], gi\|1720815... gi\|254741462 - gi\|254741462\|ref\|ZP_05199149.1\| GTP-binding protein LepA [Bacillus anthracis str. Kruger B] gi\|170707378, gi... - gi\|170707378\|ref\|ZP_02897832.1\| GTP-binding protein LepA [Bacillus anthracis str. A0389], gi\|1701276... gi\|170668645, gi... - gi\|170687450\|ref\|ZP_02878667.1\| GTP-binding protein LepA [Bacillus anthracis str. A0465], gi\|1706686... gi\|167513441, gi... - gi\|167638593\|ref\|ZP_02396869.1\| GTP-binding protein LepA [Bacillus anthracis str. A0193], gi\|1675134... gi\|167634498, gi... - gi\|167634498\|ref\|ZP_02392818.1\| GTP-binding protein LepA [Bacillus anthracis str. A0442], gi\|1675299... gi\|49181141, gi\|... - gi\|49187214\|ref\|YP_030466.1\| GTP-binding protein LepA [Bacillus anthracis str. Sterne], gi\|49181141\|... gi\|165872104, gi... - gi\|165872104\|ref\|ZP_02216744.1\| GTP-binding protein LepA [Bacillus anthracis str. A0488], gi\|1647122... gi\|254736424 - gi\|254736424\|ref\|ZP_05194130.1\| GTP-binding protein LepA [Bacillus anthracis str. Western North Amer... gi\|254721910 - gi\|254721910\|ref\|ZP_05183699.1\| GTP-binding protein LepA [Bacillus anthracis str. A1055] gi\|254684076 - gi\|254684076\|ref\|ZP_05147936.1\| GTP-binding protein LepA [Bacillus anthracis str. CNEVA-9066] LEPA_BACAC - Elongation factor 4 OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=lepA PE=3 SV=1	534.0	[0..1]	[607..1]
LEPA_BACC1 - Elongation factor 4 OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=lepA PE=3 SV=1 gi\|229198447, gi... - gi\|229198447\|ref\|ZP_04325151.1\| GTP-binding protein lepA [Bacillus cereus m1293], gi\|228584950\|gb\|EE...	534.0	[0..1]	[607..1]
LEPA_LISIN - Elongation factor 4 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=lepA PE=3 SV=1 LEPA_LISIN - Elongation factor 4 OS=Listeria innocua GN=lepA PE=3 SV=1	534.0	[0..1]	[608..1]
gi\|30264390, gi\|... - gi\|30264390\|ref\|NP_846767.1\| GTP-binding protein LepA [Bacillus anthracis str. Ames], gi\|30259048\|gb... gi\|65321692, gi\|... - gi\|65321692\|ref\|ZP_00394651.1\| COG0481: Membrane GTPase LepA [Bacillus anthracis str. A2012], ref\|NP... gi\|47504989, gi\|... - gi\|47529841\|ref\|YP_021190.1\| GTP-binding protein LepA [Bacillus anthracis str. 'Ames Ancestor'], gi\|... LEPA_BACAN - Elongation factor 4 OS=Bacillus anthracis GN=lepA PE=3 SV=1 LEPA_BACAA - Elongation factor 4 OS=Bacillus anthracis (strain A0248) GN=lepA PE=3 SV=1	534.0	[0..1]	[607..1]
LEPA_BACCR - Elongation factor 4 OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9...	534.0	[0..1]	[607..1]
LEPA_BACSK - Elongation factor 4 OS=Bacillus clausii (strain KSM-K16) GN=lepA PE=3 SV=1	533.0	[0..1]	[606..1]

Back

Predicted Domain #1

Region A:
Residues: [1-91]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKEEMNARQ KKIRNFSIIA HIDHGKSTLA DRILEQTGAL THREMKNQLL DSMDLERERG  60
   61 ITIKLNAVQL KYKAKDGETY IFHLIDTPGH V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.522879
Match:	1jnyA
Description:	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [92-188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFTYEVSRSL AACEGAILVV DAAQGIEAQT LANVYLALDN DLEILPVINK IDLPAADPER  60
   61 VREEIEDVIG LDASDAVLAS AKSGIGIEDI LEQIVEK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.76
Match:	1g7rA
Description:	Initiation factor IF2/eIF5b, domains 2 and 4; Initiation factor IF2/eIF5b, domain 3; Initiation factor IF2/eIF5b, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	4.57470667789966	bayes_pls_golite062009
structural molecule activity	3.66323426032744	bayes_pls_golite062009
translation elongation factor activity	3.16158345572509	bayes_pls_golite062009
binding	2.15223415484989	bayes_pls_golite062009
nucleic acid binding	1.50098700711558	bayes_pls_golite062009
protein binding	1.25232424749674	bayes_pls_golite062009
DNA binding	1.19194387475416	bayes_pls_golite062009
transcription regulator activity	1.12203014375349	bayes_pls_golite062009
catalytic activity	0.942640875796745	bayes_pls_golite062009
purine nucleotide binding	0.354154818458687	bayes_pls_golite062009
purine ribonucleotide binding	0.35085688811866	bayes_pls_golite062009
ribonucleotide binding	0.350844329183388	bayes_pls_golite062009
nucleotide binding	0.350227693353399	bayes_pls_golite062009
transcription activator activity	0.171881962521773	bayes_pls_golite062009
translation regulator activity	0.165004576559811	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.144513585153713	bayes_pls_golite062009
RNA binding	0.10404338295854	bayes_pls_golite062009
transcription factor activity	0.101575043176033	bayes_pls_golite062009
mRNA binding	0.0213504428103857	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [189-608]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEPSGDVNK PLKALIFDSV FDAYRGVIAN IRIMDGVVKA GDRIKMMSNG KEFEVTEVGV  60
   61 FSPKATPRDE LLVGDVGYLT AAIKNVGDTR VGDTITLANN PAEEALDGYR KLNPMVYCGL 120
  121 YPIDSSKYND LRDALEKLEL NDSALQFEAE TSQALGFGFR CGFLGLLHME IIQERIEREF 180
  181 NIDLITTAPS VIYHVNLTDG SNIVVDNPAE MPEPGVIESV EEPYVKATVM VPNDYVGAVM 240
  241 ELAQNKRGNF ITMEYLDDIR VSIVYEIPLS EIVYDFFDQL KSSTKGYASF DYELIGYKAS 300
  301 KLVKMDILLN AEKVDALSFI VHRDFAYERG KIIVEKLKEL IPRQQFEVPI QAAIATKIVS 360
  361 RSTIKALRKN VLAKCYGGDV SRKRKLLEKQ KEGKKRMKQI GSVEVPQEAF MAILKMDESK 420
  421

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.09691
Match:	2bm0A
Description:	Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	6.48160314495408	bayes_pls_golite062009
structural molecule activity	5.89785955477588	bayes_pls_golite062009
translation initiation factor activity	2.68619850021832	bayes_pls_golite062009
peptidyltransferase activity	2.36235718442873	bayes_pls_golite062009
translation elongation factor activity	1.78840251801545	bayes_pls_golite062009
mRNA binding	1.64128426760439	bayes_pls_golite062009
RNA binding	1.40868766468494	bayes_pls_golite062009
transcription regulator activity	1.30900892230008	bayes_pls_golite062009
protein binding	1.24158964059466	bayes_pls_golite062009
nucleic acid binding	1.17107716081138	bayes_pls_golite062009
binding	1.0709940954148	bayes_pls_golite062009
DNA binding	0.911272650085046	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
transcription activator activity	0.491297187941564	bayes_pls_golite062009
ribonuclease activity	0.19921800066954	bayes_pls_golite062009
sequence-specific DNA binding	0.180372638853914	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	6.9430052008157E-5	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: