YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|29542627, gi\|...
Organism:	Coxiella burnetii RSA 493
Length:	268 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29542627, gi|....

Description	E-value	Query Range	Subject Range
gi\|12655814 - gi\|12655814\|gb\|AAK00606.1\|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...	235.0	[0..1]	[264..252]
gi\|88945102, gi\|... - gi\|88945102\|ref\|ZP_01148322.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...	232.0	[0..2]	[265..250]
gi\|46579147, gi\|... - gi\|46579147\|ref\|YP_009955.1\| uroporphyrinogen III synthase/methyltransferase [Desulfovibrio vulgaris... gi\|241879973, gi... - gi\|241907550\|ref\|ZP_04792127.1\| uroporphyrin-III C-methyltransferase [Desulfovibrio vulgaris RCH1], ... gi\|120603279, gi... - gi\|120603279\|ref\|YP_967679.1\| uroporphyrin-III C-methyltransferase [Desulfovibrio vulgaris subsp. vu...	230.0	[0..2]	[267..245]
gi\|51245586, gi\|... - gi\|51245586\|ref\|YP_065470.1\| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...	228.0	[0..2]	[268..256]
gi\|147677308, gi... - gi\|98661630\|dbj\|GAA01338.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476773...	227.0	[0..2]	[266..248]
gi\|153206966, gi... - gi\|153206966\|ref\|ZP_01945784.1\| uroporphyrinogen-III synthase [Coxiella burnetii 'MSU Goat Q177'], g... gi\|94492639, gi\|... - gi\|94492639\|ref\|ZP_01299846.1\| hypothetical protein CburD_01000220 [Coxiella burnetii Dugway 7E9-12]... gi\|212013833, gi... - gi\|212219571\|ref\|YP_002306358.1\| uroporphyrinogen-III synthase [Coxiella burnetii CbuK_Q154], gi\|212...	226.0	[0..1]	[268..1]
gi\|118581774, gi... - gi\|71836333\|ref\|ZP_00676102.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Pelobacter propioni...	226.0	[0..4]	[266..253]
gi\|109645297, gi... - gi\|68208394\|ref\|ZP_00560513.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfitobacterium ...	226.0	[0..2]	[264..248]
gi\|23473894, gi\|... - gi\|78357878\|ref\|YP_389327.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	226.0	[0..2]	[266..245]
gi\|77685636, gi\|... - gi\|77685636\|ref\|ZP_00801028.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Alkaliphilus metall...	225.0	[0..2]	[265..248]

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Predicted Domain #1

Region A:
Residues: [1-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENESLKNKT IMITRPEWQG ELLKKAIERR GGAVILFPTL IIKPINKCNY SPFASASFPP  60
   61 SRESGSPDDK MTKAGFLNSS DILIFLSANA VKHSPILNFK AEQKLVAIGT GTAAALFQRG 120
  121 LSVDAVPEHF SSEGLLDLPL LHQVTGKTIA IFCGENSRPY LENELIHRGA NVFSIITYRR 180
  181 ERPVVNKKTI DALTHQTLHA IVSTSAESLQ NLCTLFESHQ HWLHRIPLVV ISKRMENLAK 240
  241 SQGFHLVLLA DNPGEKAIIK VLSTKYPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.0
Match:	1jr2A
Description:	Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen-III synthase activity	3.19339392327514	bayes_pls_golite062009
catalytic activity	1.50868196926865	bayes_pls_golite062009
hydro-lyase activity	0.850411184249311	bayes_pls_golite062009
lyase activity	0.0536528882085157	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: