YRC Public Data Repository - Protein Structure Prediction

Protein:	GCH1_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_COXBU.

Description	E-value	Query Range	Subject Range
GCH1_SYNE7 - GTP cyclohydrolase 1 OS=Synechococcus elongatus (strain PCC 7942) GN=folE PE=3 SV=2 GCH1_SYNP6 - GTP cyclohydrolase 1 OS=Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) GN=folE PE=3 ...	311.0	[0..2]	[183..25]
gi\|46118361, gi\|... - gi\|67925134\|ref\|ZP_00518508.1\| GTP cyclohydrolase I [Crocosphaera watsonii WH 8501], gi\|67853028\|gb\|...	311.0	[0..3]	[183..55]
GCH1_SYNEL - GTP cyclohydrolase 1 OS=Synechococcus elongatus GN=folE PE=3 SV=1 GCH1_THEEB - GTP cyclohydrolase 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=folE PE=3 SV=1	311.0	[0..3]	[183..44]
gi\|45513086, gi\|... - ref\|ZP_00164652.1\| COG0302: GTP cyclohydrolase I [Synechococcus elongatus PCC 7942], gi\|1399847\|gb\|...	311.0	[0..2]	[183..27]
gi\|75702476, gi\|... - gi\|75908751\|ref\|YP_323047.1\| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi\|75702476\|gb\|A...	310.0	[0..3]	[183..49]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1	308.0	[0..3]	[183..49]
gi\|25290301 - pir\|\|AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120) GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1	308.0	[0..3]	[183..49]
GCH1_SYNY3 - GTP cyclohydrolase 1 OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=folE PE=3 SV=1 GCH1_SYNY3 - GTP cyclohydrolase 1 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=folE PE=3 SV=1 gi\|7435993 - pir\|\|S76560 GTP cyclohydrolase I (EC 3.5.4.16) - Synechocystis sp. (strain PCC 6803)	306.0	[0..3]	[183..48]
gi\|49658095 - gi\|49658095\|emb\|CAG90935.1\| DEHA2G20306p [Debaryomyces hansenii] gi\|49658095, gi\|... - gi\|50427625\|ref\|XP_462425.1\| hypothetical protein DEHA0G21593g [Debaryomyces hansenii CBS767], gi\|49...	306.0	[0..2]	[184..85]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTIADHVK AILIALGEDP NREGLRDTPK RYEKALEHLT KGYHEKLPSV VKKAVFQSGM  60
   61 DEMVILKDIE LYSLCEHHLL PFIGRCHVAY LPSGKIIGIS KLARIVDMFA KRLQVQENLT 120
  121 KQIAEAILTA TEAKGVGVII EAKHLCMMMR GVEKQNSEMT TSVMLGTFRK DDRTRSEFLS 180
  181 LIRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.154902
Match:	1is7A
Description:	GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	5.27071565931386	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.94513271787536	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
binding	1.62520629128577	bayes_pls_golite062009
protein binding	1.34873192832825	bayes_pls_golite062009
hydrolase activity	1.10190985324326	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
carbon-carbon lyase activity	0.25616855487144	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: