YRC Public Data Repository - Protein Structure Prediction

Protein:	AROE_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	272 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AROE_COXBU.

Description	E-value	Query Range	Subject Range
gi\|227883413, gi... - gi\|227883413\|ref\|ZP_04001218.1\| shikimate 5-dehydrogenase [Escherichia coli 83972], gi\|227839557\|gb\|... AROE_ECOL6 - Shikimate dehydrogenase OS=Escherichia coli O6 GN=aroE PE=3 SV=1 AROE_ECOL6 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=...	267.0	[0..1]	[272..1]
gi\|191174467, gi... - gi\|75236347\|ref\|ZP_00720454.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli F11], gi\|1911744... AROE_ECOL5 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=aroE PE=3 SV...	265.0	[0..1]	[272..1]
gi\|208812766, gi... - gi\|208812766\|ref\|ZP_03254095.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4045], gi... gi\|208741939, gi... - gi\|208821816\|ref\|ZP_03262136.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4042], gi... AROE_ECO5E - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=aroE PE=3 SV... gi\|217326063, gi... - gi\|217326063\|ref\|ZP_03442147.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. TW14588], g... gi\|189374122, gi... - gi\|189374122\|gb\|EDU92538.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|189375259, gi... - gi\|189375259\|gb\|EDU93675.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|1688... gi\|195939829 - gi\|195939829\|ref\|ZP_03085211.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|208726033, gi... - gi\|208806232\|ref\|ZP_03248569.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4206], gi... gi\|168758509, gi... - gi\|189354688\|gb\|EDU73107.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|189361752, gi... - gi\|189361752\|gb\|EDU80171.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|187767009, gi... - gi\|187767009\|gb\|EDU30853.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|188998855, gi... - gi\|188998855\|gb\|EDU67841.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|168... gi\|12517908, gi\|... - gi\|15803809\|ref\|NP_289843.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|1251790... gi\|209757416, gi... - pir\|\|G85992 dehydroshikimate reductase [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|188013838, gi... - gi\|188013838\|gb\|EDU51960.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|254594618, gi... - gi\|254795218\|ref\|YP_003080055.1\| dehydroshikimate reductase, NAD(P)-binding [Escherichia coli O157:H... AROE_ECO57 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O157:H7 GN=aroE PE=3 SV=1 gi\|13363620, gi\|... - gi\|15833401\|ref\|NP_312174.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|133...	265.0	[0..1]	[272..1]
gi\|192955143, gi... - gi\|75214912\|ref\|ZP_00713391.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli E110019], gi\|193... gi\|194411670, gi... - gi\|75208432\|ref\|ZP_00708761.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli B171], gi\|194430...	264.0	[0..1]	[272..1]
AROE_SHIF8 - Shikimate dehydrogenase (NADP(+)) OS=Shigella flexneri serotype 5b (strain 8401) GN=aroE PE=3 SV=1	264.0	[0..1]	[272..1]
gi\|194435087, gi... - gi\|194435087\|ref\|ZP_03067325.1\| shikimate 5-dehydrogenase [Shigella dysenteriae 1012], gi\|194416694\|... AROE_SHIFL - Shikimate dehydrogenase (NADP(+)) OS=Shigella flexneri GN=aroE PE=3 SV=4 gi\|56480305, gi\|... - gi\|56480305\|ref\|NP_709069.2\| shikimate 5-dehydrogenase [Shigella flexneri 2a str. 301], gi\|56383856\|... gi\|30042862, gi\|... - gi\|30064603\|ref\|NP_838774.1\| shikimate 5-dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|3004286...	264.0	[0..1]	[272..1]
gi\|188490034, gi... - gi\|75511162\|ref\|ZP_00733874.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli 53638], gi\|18849...	264.0	[0..1]	[272..1]
AROE_ECO55 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli (strain 55989 / EAEC) GN=aroE PE=3 SV=1 AROE_ECOSE - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli (strain SE11) GN=aroE PE=3 SV=1 gi\|75227399, gi\|... - gi\|75227399\|ref\|ZP_00714175.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli B7A], gi\|1911693... AROE_ECO8A - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O8 (strain IAI1) GN=aroE PE=3 SV=1 AROE_ECO24 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=aroE PE=3 ...	264.0	[0..1]	[272..1]
gi\|75255420, gi\|... - gi\|75255420\|ref\|ZP_00727232.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli E22], gi\|1930664...	264.0	[0..1]	[272..1]
gi\|28949040, gi\|... - gi\|28949043\|pdb\|1NYT\|D Chain D, Shikimate Dehydrogenase Aroe Complexed With Nadp+, gi\|28949042\|pdb\|1...	263.0	[0..1]	[272..1]

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Predicted Domain #1

Region A:
Residues: [1-272]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF HDEGGKGANI  60
   61 TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN YDGLGLVQDL TRNHNITLTQ 120
  121 KSILIVGAGG ATRGILGPLL NAAPEKIVIV NRTPSKAHAL AKIFHLRGEI QGGGFDELEP 180
  181 MRYDVIIHAT SLGHQGKFPP LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL 240
  241 GMLVEHNAAV FYLWFGIYPD TNPVIEMLQA HL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.39794
Match:	1nytA
Description:	Shikimate 5-dehydrogenase AroE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
shikimate 5-dehydrogenase activity	3.40568087442781	bayes_pls_golite062009
malate dehydrogenase activity	3.18316725684556	bayes_pls_golite062009
malic enzyme activity	2.5718745582089	bayes_pls_golite062009
oxidoreductase activity	2.15129810845685	bayes_pls_golite062009
catalytic activity	2.0643953589843	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.43144163429682	bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	0.858327241653065	bayes_pls_golite062009
fatty acid synthase activity	0.714637370305282	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.39426299750207	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.192594057004213	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: