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View Structure Prediction Details

Protein: HGNC:3488|MIM:16...
Organism: SPECIES UNKNOWN
Length: 441 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:3488|MIM:16....

Description E-value Query
Range
Subject
Range
gi|54695776 - gi|54695776|gb|AAV38260.1| v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [Homo sapiens...
gi|61357900 - gi|61357900|gb|AAX41466.1| v-ets erythroblastosis virus E26 oncogene-like 1 [synthetic construct]
0.0 [1..441] [1..441]
gi|60654163 - gi|60654163|gb|AAX29774.1| v-ets erythroblastosis virus E26 oncogene-like 1 [synthetic construct]
0.0 [1..441] [1..441]
ETS1_RAT - Protein C-ets-1 OS=Rattus norvegicus GN=Ets1 PE=1 SV=1
0.0 [1..441] [1..441]
gi|73954495 - gi|73954495|ref|XP_546405.2| PREDICTED: similar to v-ets erythroblastosis virus E26 oncogene homolog...
0.0 [1..441] [1..441]
ETS1_MOUSE - Protein C-ets-1 OS=Mus musculus GN=Ets1 PE=1 SV=2
0.0 [1..440] [1..440]
gi|130502144, gi... - gi|45505311|gb|AAS67030.1| C-ets-1 [Oryctolagus cuniculus], gi|130502144|ref|NP_001076130.1| C-ets-1...
0.0 [1..441] [1..441]
gi|68891, gi|211... - pir||TVCHTE transcription factor ets-1, splice form a - chicken, gi|45384266|ref|NP_990629.1| c-ets-...
0.0 [1..441] [1..441]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ  60
   61 QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 120
  121 VGDILWEHLE ILQKEDVKPY Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 2jv3A
Description: No description for 2jv3A was found.

Predicted Domain #2
Region A:
Residues: [142-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNGVNPAYPE SRYTSDYFIS YGIEHAQCVP PSEFSEPSFI TESYQTLHPI SSEELLSLKY  60
   61 ENDY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [206-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSVILRDPLQ TDTLQNDYFA IKQEVVTPDN MCMGRTSRGK LGGQDSFESI ESYDSCDRLT  60
   61 QSWSSQSSFN SLQRVPSYDS FDSEDYPAAL PNHKPKGTFK DYVRDRADLN KDKPVIPAAA 120
  121 LAGYTGSGPI QLWQFLLELL TDKSCQSFIS WTGDGWEFKL SDPDEVARRW GKRKNKPKMN 180
  181 YEKLSRGLRY YYDKNIIHKT AGKRYVYRFV CDLQSLLGYT PEELHAMLDV KPDADE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.30103
Match: 1mdmB
Description: ETS-1 transcription factor, residues 331-440
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle