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View Structure Prediction Details

Protein: HGNC:4118|MIM:60...
Organism: SPECIES UNKNOWN
Length: 392 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:4118|MIM:60....

Description E-value Query
Range
Subject
Range
gi|61372443, gi|... - gi|61372449|gb|AAX43845.1| galactokinase 1 [synthetic construct], gi|61372443|gb|AAX43844.1| galacto...
1.0E-96 [1..392] [1..392]
GALK1_CANLF - Galactokinase OS=Canis lupus familiaris GN=GALK1 PE=2 SV=1
8.0E-95 [1..390] [1..390]
gi|149054819, gi... - gi|56605662|ref|NP_001008283.1| galactokinase 1 [Rattus norvegicus], gi|55715922|gb|AAH85919.1| Gala...
1.0E-94 [1..392] [1..392]
GALK1_MOUSE - Galactokinase OS=Mus musculus GN=Galk1 PE=1 SV=2
1.0E-93 [1..392] [1..392]
GALK1_BOVIN - Galactokinase OS=Bos taurus GN=GALK1 PE=2 SV=2
2.0E-93 [1..390] [1..390]
gi|110645593, gi... - gi|118404092|ref|NP_001072199.1| hypothetical protein LOC779645 [Xenopus (Silurana) tropicalis], gi|...
4.0E-92 [10..389] [5..385]
gi|49118537, gi|... - gi|49118537|gb|AAH73540.1| MGC82807 protein [Xenopus laevis], gi|148227080|ref|NP_001085920.1| MGC82...
6.0E-92 [8..389] [3..385]

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Predicted Domain #1
Region A:
Residues: [1-392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALRQPQVA ELLAEARRAF REEFGAEPEL AVSAPGRVNL IGEHTDYNQG LVLPMALELM  60
   61 TVLVGSPRKD GLVSLLTTSE GADEPQRLQF PLPTAQRSLE PGTPRWANYV KGVIQYYPAA 120
  121 PLPGFSAVVV SSVPLGGGLS SSASLEVATY TFLQQLCPDS GTIAARAQVC QQAEHSFAGM 180
  181 PCGIMDQFIS LMGQKGHALL IDCRSLETSL VPLSDPKLAV LITNSNVRHS LASSEYPVRR 240
  241 RQCEEVARAL GKESLREVQL EELEAARDLV SKEGFRRARH VVGEIRRTAQ AAAALRRGDY 300
  301 RAFGRLMVES HRSLRDDYEV SCPELDQLVE AALAVPGVYG SRMTGGGFGG CTVTLLEASA 360
  361 APHAMRHIQE HYGGTATFYL SQAADGAKVL CL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.154902
Match: 1wuuA
Description: crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 2.57444343595083 bayes_pls_golite062009
kinase activity 2.45533953107206 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.15678581504347 bayes_pls_golite062009
galactokinase activity 1.98579505313408 bayes_pls_golite062009
transferase activity 1.44847475955289 bayes_pls_golite062009
galactose binding 1.09822999475915 bayes_pls_golite062009
ribonuclease activity 0.861708516886368 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
binding 0.81933081762145 bayes_pls_golite062009
nuclease activity 0.750627453499812 bayes_pls_golite062009
hydrolase activity 0.740929677099368 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.29372632468704 bayes_pls_golite062009
exoribonuclease activity 0.268974873769861 bayes_pls_golite062009
protein binding 0.252740644591197 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.24527927280502 bayes_pls_golite062009
carbohydrate kinase activity 0.236567582613739 bayes_pls_golite062009
structural constituent of ribosome 0.168901349358066 bayes_pls_golite062009
peptidase activity 0.14842914604274 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle