YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24372880, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	574 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24372880, gi|....

Description	E-value	Query Range	Subject Range
gi\|50745842 - gi\|50745842\|ref\|XP_420265.1\| PREDICTED: similar to chloride channel CLC-5 [Gallus gallus]	337.0	[0..2]	[571..929]
gi\|2134911, gi\|8... - gi\|854102\|emb\|CAA55280.1\| chloride channel 3 [Homo sapiens], ref\|NP_001820.1\| chloride channel 3 [Ho...	334.0	[0..2]	[571..88]
gi\|74006439 - gi\|74006439\|ref\|XP_856009.1\| PREDICTED: similar to Chloride channel protein 4 (ClC-4) isoform 3 [Can...	334.0	[0..2]	[571..30]
CLCN3_RAT - H(+)/Cl(-) exchange transporter 3 OS=Rattus norvegicus GN=Clcn3 PE=2 SV=2	331.0	[0..2]	[571..88]
CLCN3_MOUSE - H(+)/Cl(-) exchange transporter 3 OS=Mus musculus GN=Clcn3 PE=1 SV=2	330.0	[0..2]	[571..88]

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Predicted Domain #1

Region A:
Residues: [1-444]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLTINKAAI QDAITTAKKY LTNELRDHLS QAKISAQLCL LALLFAIFAS CVILLFRLLL  60
   61 LWANHYTQIE TLDFTGNIAD WRALLPLFGA LLIWFVAKLG SKRYNRMGIA YVLHRVKLHY 120
  121 GKIPLQSAAG QFFQALFALG TNFSVGREGP AIHLGAVSAS VLAEKFNLPD NSVRIMCASG 180
  181 IAAGIAATFN APLAAVIFVI EVIVREYKVH YFFPIMLSAI CGAVSSQLVF GNVHEFDRIQ 240
  241 VIHIPLDHYP ILAIGGIVLG CAAAFFNYAL IKVTATGQNW PLIYRLLLAG SITTLIGLIL 300
  301 PQALGTGDLA ISEAISEHPS LLLLIALLVA KIVATIAAIG LGIPGGLIGP LYGIGALIGA 360
  361 ILALVSAILF PSIAPYVGLY TVIGMTAMMG VCLSAPLAAL VALLEMTNDA SIILPAMFVT 420
  421 IPAFLIAYQG FKTNSIFFKQ LEIM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.69897
Match:	1kplA
Description:	Clc chloride channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anion channel activity	5.09115218553708	bayes_pls_golite062009
chloride channel activity	5.09115218553708	bayes_pls_golite062009
anion transmembrane transporter activity	4.78770253919702	bayes_pls_golite062009
voltage-gated chloride channel activity	4.5660526535211	bayes_pls_golite062009
voltage-gated anion channel activity	4.5660526535211	bayes_pls_golite062009
ion transmembrane transporter activity	3.04763516868903	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.79706653769464	bayes_pls_golite062009
ion channel activity	1.90878598760703	bayes_pls_golite062009
substrate-specific channel activity	1.80275880685569	bayes_pls_golite062009
channel activity	1.79378044481081	bayes_pls_golite062009
passive transmembrane transporter activity	1.79378044481081	bayes_pls_golite062009
transporter activity	1.40104538148014	bayes_pls_golite062009
transmembrane transporter activity	1.27040739514162	bayes_pls_golite062009
voltage-gated ion channel activity	1.2655923201531	bayes_pls_golite062009
voltage-gated channel activity	1.25372416980603	bayes_pls_golite062009
gated channel activity	1.015284876791	bayes_pls_golite062009
substrate-specific transporter activity	0.99765601803889	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [445-574]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLGYKVAPVN LALQKKGVRA LMDKRFVIVN NNDELLLEVL KRAEGRPVLV RNADGVIEML  60
   61 SLEMQSFDDN VTLSRHPMQG LSDTKTLDEV YSILSPKRSG EVFIYQDTAD NVVGVISWSN 120
  121 LQQEIRSGQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.09691
Match:	2cu0A
Description:	No description for 2cu0A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: