YRC Public Data Repository - Protein Structure Prediction

Protein:	IQG1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	1495 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IQG1_YEAST.

Description	E-value	Query Range	Subject Range
IQG1_YEAST - Ras GTPase-activating-like protein IQG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... IQG1 - Essential protein required for determination of budding pattern, promotes localization of axial mark...	0.0	[1..1495]	[1..1495]
rng2 - IQGAP RNG2_SCHPO - Ras GTPase-activating-like protein rng2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rn...	0.0	[76..1490]	[8..1488]
IQG1_MOUSE, IQGA... - Ras GTPase-activating-like protein IQGAP1 OS=Mus musculus GN=Iqgap1 PE=1 SV=1, (Q9JKF1) Ras GTPase-a...	0.0	[606..1492]	[725..1657]
gi\|168272898 - gi\|168272898\|dbj\|BAG10288.1\| Ras GTPase-activating-like protein IQGAP1 [synthetic construct] IQGAP1 - IQ motif containing GTPase activating protein 1	0.0	[606..1492]	[725..1657]
gi\|148234245, gi... - gi\|29647401\|dbj\|BAC75407.1\| IQ motif containing GTPase activating protein 1 [Xenopus laevis], gi\|148...	0.0	[581..1492]	[666..1618]
gi\|3668187 - gi\|3668187\|dbj\|BAA33452.1\| myosin heavy chain [Theragra chalcogramma]	0.0	[160..1028]	[382..1274]

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Predicted Domain #1

Region A:
Residues: [1-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAYSGSPSK PGNNNSYLNR YVENLGTNVT PPLRPQSSSK INSSLNIASP SHLKTKTSAS  60
   61 NSSATILSKK VESSVSKLKP SLPNKL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [87-675]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGKYTVDLSN YSKIELRYYE FLCRVSEVKI WIEAVIEEAL PSEIELCVGD SLRNGVFLAK  60
   61 LTQRINPDLT TVIFPAGDKL QFKHTQNINA FFGLVEHVGV PDSFRFELQD LYNKKNIPQV 120
  121 FETLHILISM INKKWPGKTP ALTNVSGQIS FTKEEIAACK KAWPRIRDFK SLGTNINTAP 180
  181 ASPEEPKEKR SGLIKDFNKF ERPNIPVEEI LITPRKNITD ANCSDFSNTP SPYNEAPKMS 240
  241 NLDVVVEKRK FTPIEPSLLG PTPSLEYSPI KNKSLSYYSP TISKYLTYDT EFYTRRSRAR 300
  301 EEDLNYYQTF KYSPSHYSPM RRERMTEEQF LEKVVQLQNI CRGVNTRFNL YIQKRLLNLF 360
  361 EQDILRFQAC LRGNKFRVLS SMYLPIRRAK IDVPHVEAIQ SRIKGSRIRY KYDKLKFTLS 420
  421 RFSCTVELLQ AYCRSKLLKT TVNTKLNDIE ISHYPLTKLQ SYMRASYVRK KVMSLNTKLN 480
  481 DERESIMKFS AIIRGNVVRC SEDAILSAVH DVHKENISKL QSLIRGIFTR SCLASIIYSL 540
  541 GKENCNIIQL SACIRGNAVR HKVQSLFAPE NNLSETVHDL QGLVRGILV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.0
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [676-973]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYTLDLVDDI VEYNNLALFQ AFSRGALVRE SLDQKSSFYK RNVRSVIMIQ SWIRKSLQRS  60
   61 AYLELLDCPN PSLWAVKKFV HLLNGTATIE EVQNQLESCQ ASLDSENMKK ERLLKSIRQQ 120
  121 LNINGVLDKF GLLKDKDHEL GISDSTIPKS KYQKYEKLFY MLQVDPSYWK LLYLKEPEFV 180
  181 AKNVYMTFGT VNQRMNDRER SYFTRFVCEM LQNAINEAPS IESFLDNRSQ FWQTILQDFL 240
  241 RRESPEFFSI IVPVLDYLSD PVVDFESDPY KIYQEIHGFS SPQHCSPVDD ASTKNKFI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.0
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [974-1168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLRCLWHAI EMVAEIYTRK VHTIPVEIRY LCTKIFCYAA DKNIEEIDSL RAISSILVNV  60
   61 FVSEYLVNRE YYGYKDSNVQ KNNQKIDILM KSLATVFEIK NFDGFLDPLN QYANEIKPHI 120
  121 KDVLYNVLVD PEYEQEGDRL IYLDMVSPSP KLELLTEKVL EISGKFEEYL NEFPEADILH 180
  181 DILEKNLDNS SFPRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	1nf1A_
Description:	GAP related domain of neurofibromin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [1169-1249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRVTLELDAS AYRFLVSDDK MRKIYDQVKR AFVYMMQIED VDTNLYDLSI STILPQDEPN  60
   61 FANFLEQNPK IRDDPMIQKL K

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1250-1495]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLKYFTLKNV TLKKIHELES TGTFCSSDNK LQNFLNDIAN TIKNPNYAID YVTQEIYITK  60
   61 ETLTKISEMN HSLDIELSRL KKHVDHTIKD FQKAKDFSPV HKSKFGNFKN AVKKVQGRER 120
  121 SELQGMKFKW NTKQLYERGV LKTIRGEKLA ELTVKVFGSS GPKFPDIIFK ISTSDGSRFG 180
  181 IQMIDKRKGP DKRYSDDVDS FSFKDLIKTQ VEPKIETWKL FHSNVVVNNS QLLHLIVSFF 240
  241 YKRNAL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
actin binding	4.78749876353566	bayes_pls_golite062009
GTPase regulator activity	3.48313315541019	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	3.46216378778416	bayes_pls_golite062009
cytoskeletal protein binding	3.44145669357816	bayes_pls_golite062009
enzyme regulator activity	2.73117303901364	bayes_pls_golite062009
calmodulin binding	2.44376064579262	bayes_pls_golite062009
binding	2.21550924222852	bayes_pls_golite062009
small GTPase regulator activity	1.52776228366828	bayes_pls_golite062009
protein binding	1.37785152807615	bayes_pls_golite062009
Ras GTPase activator activity	1.32591250158464	bayes_pls_golite062009
GTPase inhibitor activity	1.1177126331255	bayes_pls_golite062009
Rho GTPase binding	1.00104187823298	bayes_pls_golite062009
GTPase activator activity	0.945543525650563	bayes_pls_golite062009
small GTPase binding	0.78616895231719	bayes_pls_golite062009
GTPase binding	0.76727022636058	bayes_pls_golite062009
enzyme activator activity	0.514378360493585	bayes_pls_golite062009
enzyme binding	0.44096806806257	bayes_pls_golite062009
Ras GTPase binding	0.245740027562592	bayes_pls_golite062009
enzyme inhibitor activity	0.0914865633301911	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: