YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|294504172\|ref...
Organism:	Yersinia pestis Z176003
Length:	278 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|294504172|ref....

Description	E-value	Query Range	Subject Range
gi\|238728942, gi... - gi\|77980020\|ref\|ZP_00835435.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Yersinia in...	2.0E-84	[1..277]	[1..277]
gi\|77956323 - gi\|77956323\|ref\|ZP_00820434.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Yersinia be...	4.0E-84	[1..278]	[1..278]
gi\|18977526, gi\|... - gi\|18977526\|ref\|NP_578883.1\| NAD-dependent deacetylase [Pyrococcus furiosus DSM 3638], gi\|18893233\|g...	2.0E-81	[13..268]	[34..293]
gi\|36786133, gi\|... - gi\|37526701\|ref\|NP_930045.1\| NAD-dependent deacetylase [Photorhabdus luminescens subsp. laumondii TT...	3.0E-80	[12..273]	[15..276]
NPD_PYRFU - NAD-dependent deacetylase OS=Pyrococcus furiosus GN=npdA PE=3 SV=2 NPD_PYRFU - NAD-dependent protein deacylase OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc...	1.0E-79	[28..268]	[2..246]
gi\|50120757, gi\|... - gi\|50120757\|ref\|YP_049924.1\| NAD-dependent deacetylase [Pectobacterium atrosepticum SCRI1043], gi\|49...	2.0E-79	[1..272]	[1..272]
NPD_PYRHO - NAD-dependent deacetylase OS=Pyrococcus horikoshii GN=npdA PE=3 SV=1 NPD_PYRHO - NAD-dependent protein deacylase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 ...	8.0E-79	[28..271]	[2..249]
gi\|253773856, gi... - gi\|254288035\|ref\|YP_003053783.1\| NAD-dependent deacetylase [Escherichia coli BL21(DE3)], gi\|25397734... gi\|16129083\|ref\|... - NAD-dependent deacetylase [Escherichia coli K12], deacetylase of acetyl-CoA synthetase, NAD-dependen... gi\|83584887, gi\|... - gi\|83584887\|ref\|ZP_00923545.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|251784650, gi... - gi\|251784650\|ref\|YP_002998954.1\| hypothetical protein B21_01126 [Escherichia coli BL21], gi\|24237692... gi\|4062692, gi\|8... - gi\|89107966\|ref\|AP_001746.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli s... gi\|238860741, gi... - gi\|238900374\|ref\|YP_002926170.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia co... gi\|75511391, gi\|... - gi\|75511391\|ref\|ZP_00734074.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|4062692, gi\|1... - gi\|4062692\|dbj\|BAA35940.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia coli W31... gi\|124499575, gi... - gi\|124529867\|ref\|ZP_01700711.1\| Silent information regulator protein Sir2 [Escherichia coli B], gi\|1... gi\|169755413, gi... - gi\|170020485\|ref\|YP_001725439.1\| NAD-dependent deacetylase [Escherichia coli ATCC 8739], gi\|16975541... gi\|170080771, gi... - gi\|170080771\|ref\|YP_001730091.1\| deacetylase of acetyl-CoA synthetase, NAD-dependent [Escherichia co... gi\|157160646, gi... - gi\|75195303\|ref\|ZP_00705373.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... NPD_ECOLI - NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) - Escherichia coli gi\|256023182\|ref... - NAD-dependent deacetylase [Escherichia sp. 4_1_40B] gi\|254161227, gi... - gi\|254161227\|ref\|YP_003044335.1\| NAD-dependent deacetylase [Escherichia coli B str. REL606], gi\|2539...	1.0E-78	[2..272]	[4..274]
gi\|24051417, gi\|... - gi\|24112525\|ref\|NP_707035.1\| NAD-dependent deacetylase [Shigella flexneri 2a str. 301], gi\|24051417\|... NPD_SHIFL - NAD-dependent deacetylase OS=Shigella flexneri GN=cobB PE=3 SV=1 gi\|30062653, gi\|... - gi\|30062653\|ref\|NP_836824.1\| NAD-dependent deacetylase [Shigella flexneri 2a str. 2457T], gi\|3004090... gi\|110614682, gi... - gi\|110805134\|ref\|YP_688654.1\| NAD-dependent deacetylase [Shigella flexneri 5 str. 8401], gi\|11061468...	1.0E-78	[2..271]	[4..273]
gi\|75239618, gi\|... - gi\|75239618\|ref\|ZP_00723585.1\| COG0846: NAD-dependent protein deacetylases, SIR2 family [Escherichia... gi\|115512429, gi... - gi\|117623305\|ref\|YP_852218.1\| NAD-dependent deacetylase [Escherichia coli APEC O1], gi\|115512429\|gb\|... gi\|215264403, gi... - gi\|215486331\|ref\|YP_002328762.1\| NAD-dependent deacetylase [Escherichia coli O127:H6 str. E2348/69],... gi\|218689072, gi... - gi\|218689072\|ref\|YP_002397284.1\| NAD-dependent deacetylase [Escherichia coli ED1a], gi\|218426636\|emb... gi\|218364770, gi... - gi\|218558001\|ref\|YP_002390914.1\| NAD-dependent deacetylase [Escherichia coli S88], gi\|218364770\|emb\|... NPD_ECOL6 - NAD-dependent deacetylase OS=Escherichia coli O6 GN=cobB PE=3 SV=1 gi\|227886523, gi... - gi\|227886523\|ref\|ZP_04004328.1\| NAD-dependent deacetylase [Escherichia coli 83972], gi\|227836727\|gb\|... gi\|110641296, gi... - gi\|110641296\|ref\|YP_669026.1\| NAD-dependent deacetylase [Escherichia coli 536], gi\|110342888\|gb\|ABG6... gi\|237706894, gi... - gi\|237706894\|ref\|ZP_04537375.1\| NAD-dependent deacetylase [Escherichia sp. 3_2_53FAA], gi\|226898104\|... gi\|91071849, gi\|... - gi\|91210275\|ref\|YP_540261.1\| NAD-dependent deacetylase [Escherichia coli UTI89], gi\|91071849\|gb\|ABE0... gi\|26247264, gi\|... - gi\|26247264\|ref\|NP_753304.1\| NAD-dependent deacetylase [Escherichia coli CFT073], gi\|26107665\|gb\|AAN...	2.0E-78	[2..268]	[4..270]

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Predicted Domain #1

Region A:
Residues: [1-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIRHRLCRF RKSKHVRHQR FRSRIFHRDS AVAKEMKKPF VVVLTGAGIS AESGIRTFRA  60
   61 DDGLWEDHRV EDVATPEGYR RDPELVQRFY NERRRQLQQP DIAPNAAHFA LADLEAVLGD 120
  121 NLVLITQNID NLHERAGSKR VIHMHGELLK VRCTQSGQVL DWQGDLSADE RCHCCQFPSP 180
  181 LRPHIVWFGE MPMGMDDIYQ ALAEADFFIS IGTSGHVYPA AGFVHESHLH GAHTVELNLE 240
  241 PSQVESQFDE KHYGLASKVV PEYIREFLTT CGENRQGD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.30103
Match:	1s5pA
Description:	Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
NAD+ ADP-ribosyltransferase activity	4.48704850626003	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	4.08149624941135	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	4.08149624941135	bayes_pls_golite062009
histone deacetylase activity	3.74635494719834	bayes_pls_golite062009
protein deacetylase activity	3.73517183779114	bayes_pls_golite062009
deacetylase activity	2.90596007012043	bayes_pls_golite062009
transcription regulator activity	1.39353160159826	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1.38412624618353	bayes_pls_golite062009
binding	1.164162613645	bayes_pls_golite062009
nucleic acid binding	1.03756862593859	bayes_pls_golite062009
DNA binding	0.973717421708349	bayes_pls_golite062009
transcription repressor activity	0.932685017422521	bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	0.843570054817722	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
transcription corepressor activity	0.367921248703219	bayes_pls_golite062009
protein binding	0.219904988883186	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.114062221123972	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: