YRC Public Data Repository - Protein Structure Prediction

Protein:	RNZ_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	838 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNZ_YEAST.

Description	E-value	Query Range	Subject Range
RNZ_YEAST - Ribonuclease Z OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRZ1 PE=1 SV=1 TRZ1 - tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetical...	0.0	[1..838]	[1..838]
gi\|22330184, gi\|... - gi\|22330184\|ref\|NP_175628.2\| TRZ3 (TRNASE Z 3); 3'-tRNA processing endoribonuclease/ catalytic [Arab...	0.0	[4..831]	[106..888]
gi\|148678451, gi... - gi\|148678451\|gb\|EDL10398.1\| elaC homolog 2 (E. coli), isoform CRA_a [Mus musculus], gi\|13540342\|gb\|A...	0.0	[4..826]	[51..784]
gi\|48146639, gi\|... - gi\|48146639\|emb\|CAG33542.1\| ELAC2 [Homo sapiens], gi\|21359941\|ref\|NP_060597.3\| elaC homolog 2 [Homo ...	0.0	[4..813]	[59..775]
RNZ2_GORGO - Zinc phosphodiesterase ELAC protein 2 OS=Gorilla gorilla gorilla GN=ELAC2 PE=2 SV=1 gi\|10946489 - gi\|10946489\|gb\|AAG24916.1\|AF308694_1 ELAC2 [Gorilla gorilla]	0.0	[4..813]	[59..775]
RNZ2_PANTR - Zinc phosphodiesterase ELAC protein 2 OS=Pan troglodytes GN=ELAC2 PE=2 SV=1	0.0	[4..813]	[59..775]

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Predicted Domain #1

Region A:
Residues: [1-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTFIPITHP TSDTKHPLLL VQSAHGEKYF FGKIGEGSQR SLTENKIRIS KLKDIFLTGE  60
   61 LNWSDIGGLP GMILTIADQG KSNLVLHYGN DILNYIVSTW RYFVFRFGID LNDHIMKDKE 120
  121 VYKDKIIAVK SFNVLKNGGE DRLGVFDSFQ KGVLRSIVAK MFPKHAPTDR YDPSSDPHLN 180
  181 VELPDLDAKV EVSTNYEISF SPVR

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.66
Match:	1qh5A
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.25638799652541	bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity	0.998280249151351	bayes_pls_golite062009
nucleic acid binding	0.980281910076056	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
RNA binding	0.794779546418275	bayes_pls_golite062009
protein binding	0.0732519352239051	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [205-308]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKFKVEEAIK LGVPKGPLFA KLTKGQTITL DNGIVVTPEQ VLENERHFAK VLILDIPDDL  60
   61 YLNAFVEKFK DYDCAELGMV YYFLGDEVTI NDNLFAFIDI FEKN

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.66
Match:	1qh5A
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.31163219351982	bayes_pls_golite062009
nucleic acid binding	0.995499818152009	bayes_pls_golite062009
catalytic activity	0.888964130802536	bayes_pls_golite062009
RNA binding	0.752641444664237	bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity	0.6076643116915	bayes_pls_golite062009
protein binding	0.104060533429009	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [309-456]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYGKVNHMIS HNKISPNTIS FFGSALTTLK LKALQVNNYN LPKTDRVFSK DFYDRFDTPL  60
   61 SRGTSMCKSQ EEPLNTIIEK DNIHIFSQNK TVTFEPFRMN EEPMKCNING EVADFSWQEI 120
  121 FEEHVKPLEF PLADVDTVIN NQLHVDNF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [457-639]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSAEKKKHV EIITLGTGSA LPSKYRNVVS TLVKVPFTDA DGNTINRNIM LDAGENTLGT  60
   61 IHRMFSQLAV KSIFQDLKMI YLSHLHADHH LGIISVLNEW YKYNKDDETS YIYVVTPWQY 120
  121 HKFVNEWLVL ENKEILKRIK YISCEHFIND SFVRMQTQSV PLAEFNEILK ENSNQESNRK 180
  181 LEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.30103
Match:	1e5dA_
Description:	Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.25638799652541	bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity	0.998280249151351	bayes_pls_golite062009
nucleic acid binding	0.980281910076056	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
RNA binding	0.794779546418275	bayes_pls_golite062009
protein binding	0.0732519352239051	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [640-838]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRDSSYRDVD LIRQMYEDLS IEYFQTCRAI HCDWAYSNSI TFRMDENNEH NTFKVSYSGD  60
   61 TRPNIEKFSL EIGYNSDLLI HEATLENQLL EDAVKKKHCT INEAIGVSNK MNARKLILTH 120
  121 FSQRYPKLPQ LDNNIDVMAR EFCFAFDSMI VDYEKIGEQQ RIFPLLNKAF VEEKEEEEDV 180
  181 DDVESVQDLE VKLKKHKKN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: