YRC Public Data Repository - Protein Structure Prediction

Protein:	ENSPTRT00000014925
Organism:	Pan troglodytes
Length:	313 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENSPTRT00000014925.

Description	E-value	Query Range	Subject Range
gi\|57043872 - gi\|57043872\|ref\|XP_544419.1\| PREDICTED: similar to seven in absentia homolog 1 isoform b isoform 1 [...	1.0E-76	[1..313]	[1..313]
gi\|76640366 - gi\|76640366\|ref\|XP_875974.1\| PREDICTED: similar to seven in absentia homolog 1 isoform b [Bos taurus...	3.0E-73	[19..313]	[241..535]
gi\|50753723 - gi\|50753723\|ref\|XP_414105.1\| PREDICTED: similar to SIAH1 protein [Gallus gallus]	1.0E-72	[31..313]	[369..651]
gi\|68389919 - gi\|68389919\|ref\|XP_707669.1\| PREDICTED: similar to Seven in absentia 1A isoform 2 [Danio rerio]	2.0E-72	[29..313]	[50..334]
gi\|60654479 - gi\|60654479\|gb\|AAX29930.1\| seven in absentia-like 1 [synthetic construct]	1.0E-71	[32..313]	[1..282]
gi\|123994983, gi... - gi\|61364081\|gb\|AAX42488.1\| seven in absentia-like 1 [synthetic construct], gi\|123994983\|gb\|ABM85093.... gi\|109128441 - gi\|109128441\|ref\|XP_001114318.1\| PREDICTED: seven in absentia homolog 1 isoform 2 [Macaca mulatta] gi\|55666665 - gi\|55666665\|ref\|XP_520625.1\| PREDICTED: seven in absentia homolog 1 [Pan troglodytes] gi\|55749567 - ref\|NP_001006612.1\| seven in absentia homolog 1 isoform c [Homo sapiens] SIAH1 - seven in absentia homolog 1 (Drosophila)	1.0E-71	[32..313]	[1..282]
gi\|34366098, gi\|... - ref\|NP_003022.2\| seven in absentia homolog 1 [Homo sapiens], gi\|34366098\|emb\|CAE46191.1\| hypothetic...	2.0E-71	[32..313]	[1..282]
gi\|62751353, gi\|... - gi\|62751353\|ref\|NP_001015836.1\| seven in absentia homolog 1 [Xenopus (Silurana) tropicalis], gi\|5847... gi\|49117837, gi\|... - gi\|49117837\|gb\|AAH72747.1\| MGC79105 protein [Xenopus laevis], gi\|148231169\|ref\|NP_001085438.1\| MGC79...	2.0E-71	[32..313]	[1..282]
gi\|423568, gi\|66... - gi\|6677949\|ref\|NP_033199.1\| seven in absentia 1B [Mus musculus], pir\|\|S35754 siah-1B protein - mouse...	2.0E-71	[32..313]	[1..282]

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Predicted Domain #1

Region A:
Residues: [1-132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGKATPPSL YSWRGVLFTC LPAARTRKRK EMSRQTATAL PTGTSKCPPS QRVPALTGTT  60
   61 ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK 120
  121 VANSVLFPCK YA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.522879
Match:	1rmdA
Description:	RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	5.32809533104435	bayes_pls_golite062009
small conjugating protein ligase activity	5.17943669371679	bayes_pls_golite062009
acid-amino acid ligase activity	4.2482314105959	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	3.07217714843839	bayes_pls_golite062009
binding	2.15929427993458	bayes_pls_golite062009
protein binding	1.49775478023418	bayes_pls_golite062009
small conjugating protein-specific protease activity	0.786612602432575	bayes_pls_golite062009
ligase activity	0.63517530468004	bayes_pls_golite062009
peptidase activity	0.629020501929934	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.616462655649223	bayes_pls_golite062009
ubiquitin-specific protease activity	0.549461161056205	bayes_pls_golite062009
transcription regulator activity	0.181063140818134	bayes_pls_golite062009
cysteine-type peptidase activity	0.159023519781458	bayes_pls_golite062009
hydrolase activity	0.156835837705934	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
nucleic acid binding	0.125491277540945	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [133-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGCEITLPH TEKADHEELC EFRPYSCPCP GASCKWQGSL DAVMPHLMHQ HKSITTLQGE  60
   61 DIVFLATDIN LPGAVDWVMM QSCFGFHFML VLEKQEKYDG HQQFFAIVQL IGTRKQAENF 120
  121 AYRLELNGHR RRLTWEATPR SIHEGIATAI MNSDCLVFDT SIAQLFAENG NLGINVTISM 180
  181 C

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.154902
Match:	2a25A
Description:	Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: