YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254722747
Organism:	Bacillus anthracis str. A1055
Length:	344 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254722747.

Description	E-value	Query Range	Subject Range
gi\|49479147, gi\|... - gi\|49479147\|ref\|YP_036864.1\| acetoin dehydrogenase (TPP-dependent) E1 component beta subunit [Bacill...	2.0E-92	[1..344]	[1..344]
gi\|42737784, gi\|... - gi\|42781860\|ref\|NP_979107.1\| TPP-dependent acetoin dehydrogenase E1 beta-subunit [Bacillus cereus AT...	4.0E-92	[1..344]	[1..344]
gi\|30020899, gi\|... - gi\|30020899\|ref\|NP_832530.1\| acetoin dehydrogenase E1 component beta-subunit [Bacillus cereus ATCC 1...	4.0E-92	[1..344]	[1..344]
gi\|52142735, gi\|... - gi\|52142735\|ref\|YP_084093.1\| acetoin dehydrogenase (TPP-dependent) E1 component beta subunit [Bacill... gi\|218903895, gi... - gi\|218903895\|ref\|YP_002451729.1\| TPP-dependent acetoin dehydrogenase E1 beta-subunit [Bacillus cereu... gi\|196027489, gi... - gi\|196041720\|ref\|ZP_03109011.1\| TPP-dependent acetoin dehydrogenase E1 beta-subunit [Bacillus cereus... gi\|195995356, gi... - gi\|196032605\|ref\|ZP_03100019.1\| TPP-dependent acetoin dehydrogenase E1 beta-subunit [Bacillus cereus...	5.0E-92	[1..344]	[1..344]
gi\|163940523, gi... - gi\|89207402\|ref\|ZP_01185944.1\| Transketolase, central region:Transketolase, C-terminal [Bacillus wei...	7.0E-92	[1..344]	[1..344]
gi\|47554307, gi\|... - gi\|47569038\|ref\|ZP_00239728.1\| acetoin dehydrogenase, beta subunit [Bacillus cereus G9241], gi\|47554...	9.0E-92	[1..344]	[1..344]
gi\|52002493, gi\|... - gi\|52784648\|ref\|YP_090477.1\| hypothetical protein BLi00850 [Bacillus licheniformis ATCC 14580], gi\|5...	4.0E-91	[1..338]	[1..338]
gi\|150963537, gi... - gi\|94414063\|ref\|ZP_01293929.1\| hypothetical protein PaerP_01004206 [Pseudomonas aeruginosa PA7], gi\|...	2.0E-89	[1..339]	[1..336]
gi\|68343839, gi\|... - gi\|70729540\|ref\|YP_259278.1\| acetoin dehydrogenase E1 component, beta subunit [Pseudomonas fluoresce...	3.0E-89	[1..336]	[1..333]
gi\|74489820, gi\|... - gi\|75762699\|ref\|ZP_00742536.1\| Acetoin dehydrogenase E1 component beta-subunit [Bacillus thuringiens...	3.0E-89	[1..344]	[1..344]

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Predicted Domain #1

Region A:
Residues: [1-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRTVSMSTA INEAMKISMR RDENVILIGE DVAGGAQVDH LQDDEAWGGV LGVTKGLVQE  60
   61 FGRNRILDTP ISEAGYMGAA MAAAATGLRP IAELMFNDFI GSCLDQVLNQ GAKFRYMFGG 120
  121 KAKVPVTVRT MHGAGFSAAA QHSQSLYALF TSIPGIKVVV PSTPYDAKGL LLAAIEDDDP 180
  181 VIFFEDKTLY NMKGEVPEGY YTIPLGKADI KREGSDVTIV AIGKQVHTAL AAAEQLAKKG 240
  241 LEVEVIDPRS LSPLDEDTIL SSVEKTNRLI VIDEANPRCS IATDIAAIVA DRGFDLLDAP 300
  301 IKRITAPHTP VPFSPPLEKL YLPTPEKVIE TVSEMIGDQS LLHV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.154902
Match:	1w85B
Description:	The crystal structure of pyruvate deydrogenase E1 bound to the peripheral subunit binding domain of E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.65146926050423	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.53492491341322	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
binding	0.551586872853971	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: