YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|255028745
Organism:	Listeria monocytogenes LO28
Length:	371 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|255028745.

Description	E-value	Query Range	Subject Range
gi\|116872446, gi... - gi\|116872446\|ref\|YP_849227.1\| pyruvate dehydrogenase alpha subunit [Listeria welshimeri serovar 6b s... gi\|254933400, gi... - gi\|254933400\|ref\|ZP_05266759.1\| pyruvate dehydrogenase (E1 alpha subunit) [Listeria monocytogenes HP... gi\|254823675 - gi\|254823675\|ref\|ZP_05228676.1\| pyruvate dehydrogenase (E1 alpha subunit) [Listeria monocytogenes FS... gi\|153166387, gi... - gi\|153166387\|ref\|ZP_01926973.1\| pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase... gi\|226223670, gi... - gi\|226223670\|ref\|YP_002757777.1\| pyruvate dehydrogenase (E1 alpha subunit) [Listeria monocytogenes C... gi\|254880077 - gi\|254880077\|ref\|ZP_05252787.1\| pyruvate dehydrogenase (E1 alpha subunit) [Listeria monocytogenes FS... gi\|254853061 - gi\|254853061\|ref\|ZP_05242409.1\| pyruvate dehydrogenase (E1 alpha subunit) [Listeria monocytogenes FS... gi\|16800113 - gi\|16800113\|ref\|NP_470381.1\| hypothetical protein lin1044 [Listeria innocua Clip11262] gi\|25284413, gi\|... - pir\|\|AC1563 pyruvate dehydrogenase (E1 alpha chain) homolog pdhA [imported] - Listeria innocua (stra... gi\|46907284, gi\|... - gi\|46907284\|ref\|YP_013673.1\| pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase al...	303.0	[0..1]	[371..1]
gi\|72495520, gi\|... - gi\|73663005\|ref\|YP_301786.1\| pyruvate dehydrogenase E1 component alpha subunit [Staphylococcus sapro...	289.0	[0..6]	[371..5]
gi\|154685875, gi... - gi\|92012070\|emb\|CAJ57405.1\| pyruvate dehydrogenase (E1 alpha subunit) [Bacillus amyloliquefaciens FZ...	289.0	[0..1]	[371..1]
gi\|70726860, gi\|... - gi\|70726860\|ref\|YP_253774.1\| pyrubate dehydrogenase E1 component alpha subunit [Staphylococcus haemo...	288.0	[0..6]	[371..5]
gi\|52080059, gi\|... - gi\|52785434\|ref\|YP_091263.1\| PdhA [Bacillus licheniformis ATCC 14580], gi\|52347936\|gb\|AAU40570.1\| Pd...	286.0	[0..1]	[371..1]
gi\|257795176\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus A978... ODPA_STAAN - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain N315) GN=pdhA PE=... ODPA_STAAW - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain MW2) GN=pdhA PE=3... gi\|258451960\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus A5948] gi\|282925277\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus A976... gi\|87202350, gi\|... - gi\|88194792\|ref\|YP_499589.1\| pyruvate dehydrogenase complex, E1 component, alpha subunit, putative [... ODPA_STAAM - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain Mu50 / ATCC 70069... gi\|87126728, gi\|... - gi\|87160754\|ref\|YP_493691.1\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus aure... gi\|258421793\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus A971... gi\|151221171, gi... - gi\|151221171\|ref\|YP_001331993.1\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus ... gi\|156721551, gi... - gi\|156979416\|ref\|YP_001441675.1\| pyrubate dehydrogenase E1 component alpha subunit [Staphylococcus a... gi\|269202704\|ref... - pyruvate dehydrogenase complex E1 component, alpha subunit [Staphylococcus aureus subsp. aureus ED98... gi\|258449861\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus A6224] ODPA_STAAC - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain COL) GN=pdhA PE=3... gi\|262052201\|ref... - pyruvate dehydrogenase E1 component alpha subunit [Staphylococcus aureus 930918-3] gi\|283770155\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus subsp. aureus H19] gi\|282894120\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus A811... gi\|255005880 - gi\|255005880\|ref\|ZP_05144481.2\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus a... gi\|253733672, gi... - gi\|253733672\|ref\|ZP_04867837.1\| pyruvate dehydrogenase E1 component alpha subunit [Staphylococcus au... gi\|87160754\|ref\|... - pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus aureus subsp. aureus USA300], pyr... gi\|253731704, gi... - gi\|253731704\|ref\|ZP_04865869.1\| pyruvate dehydrogenase E1 component alpha subunit [Staphylococcus au... gi\|258407115\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus A9763] gi\|253316346 - gi\|253316346\|ref\|ZP_04839559.1\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus a... gi\|251802448, gi... - gi\|251813995\|ref\|ZP_04828468.1\| pyruvate dehydrogenase E1 component alpha subunit [Staphylococcus au... gi\|161509276, gi... - gi\|161509276\|ref\|YP_001574935.1\| pyruvate dehydrogenase (acetyl-transferring) alpha subunit [Staphyl... gi\|258444964\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus A6300] gi\|90583640, gi\|... - gi\|90583640\|ref\|ZP_01239393.1\| Pyruvate dehydrogenase (lipoamide) [Staphylococcus aureus subsp. aure... gi\|221138711 - gi\|221138711\|ref\|ZP_03563513.1\| pyruvate dehydrogenase (acetyl-transferring) alpha subunit [Staphylo... gi\|90430363, gi\|... - gi\|90586087\|ref\|ZP_01241790.1\| Dehydrogenase, E1 component [Staphylococcus aureus subsp. aureus JH9]... gi\|221140507 - gi\|221140507\|ref\|ZP_03565000.1\| pyruvate dehydrogenase (acetyl-transferring) alpha subunit [Staphylo... gi\|258443354\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus A8115] gi\|284024018\|ref... - pyruvate dehydrogenase complex E1 component, alpha subunit [Staphylococcus aureus subsp. aureus 132] gi\|258454960\|ref... - pyruvate dehydrogenase complex E1 component [Staphylococcus aureus A5937] gi\|282916343\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|282928615\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus A101... ODPA_STAAS - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain MSSA476) GN=pdhA ... gi\|258436157\|ref... - pyruvate dehydrogenase E1 component [Staphylococcus aureus A9299]	286.0	[0..6]	[371..5]
gi\|56379435, gi\|... - gi\|56419593\|ref\|YP_146911.1\| dehydrogenase E1 component, alpha subunit (lipoamide) [Geobacillus kaus...	285.0	[0..12]	[371..10]
gi\|221322851 - gi\|221322851\|ref\|ZP_03604145.1\| pyruvate dehydrogenase (E1 alpha subunit) [Bacillus subtilis subsp. ... gi\|221318577 - gi\|221318577\|ref\|ZP_03599871.1\| pyruvate dehydrogenase (E1 alpha subunit) [Bacillus subtilis subsp. ... gi\|221313655 - gi\|221313655\|ref\|ZP_03595460.1\| pyruvate dehydrogenase (E1 alpha subunit) [Bacillus subtilis subsp. ... ODPA_BACSU - Pyruvate dehydrogenase E1 component subunit alpha OS=Bacillus subtilis GN=pdhA PE=1 SV=3 ODPA_BACSU - Pyruvate dehydrogenase E1 component subunit alpha OS=Bacillus subtilis (strain 168) GN=pdhA PE=1 SV=...	284.0	[0..1]	[371..1]
gi\|257427808\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus subsp. aureus 65-1322] gi\|227558697, gi... - gi\|227558697\|ref\|ZP_03988744.1\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus a... gi\|227851134, gi... - gi\|227900484\|ref\|ZP_04018289.1\| pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus a... gi\|282913868\|ref... - pyruvate dehydrogenase complex E1 component, alpha subunit [Staphylococcus aureus subsp. aureus M899... gi\|257433145\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus subsp. aureus E1410] gi\|293500905\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... ODPA_STAAR - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus aureus (strain MRSA252) GN=pdhA ... gi\|282918792\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|282905411\|ref... - pyruvate dehydrogenase acetyl-transferring E1 component alpha subunit [Staphylococcus aureus subsp. ... gi\|293526447\|ref... - pyruvate dehydrogenase complex E1 component, alpha subunit [Staphylococcus aureus subsp. aureus M101... gi\|282910670\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|257425145\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus subsp. aureus 55/2053] gi\|257430443\|ref... - pyruvate dehydrogenase E1 component subunit alpha [Staphylococcus aureus subsp. aureus 68-397] gi\|282923914\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|293509861\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|282908383\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|283957837\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs... gi\|257436044\|ref... - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit [Staphylococcus aureus subs...	284.0	[0..6]	[371..5]
gi\|242242398, gi... - gi\|242242398\|ref\|ZP_04796843.1\| pyrubate dehydrogenase E1 component alpha subunit [Staphylococcus ep... ODPA_STAEQ - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus epidermidis (strain ATCC 35984 /... gi\|251805957, gi... - gi\|251810546\|ref\|ZP_04825019.1\| pyrubate dehydrogenase E1 component alpha subunit [Staphylococcus ep... ODPA_STAEP - (Q8CPN3) Pyruvate dehydrogenase E1 component, alpha subunit (EC 1.2.4.1) ODPA_STAES - Pyruvate dehydrogenase E1 component subunit alpha OS=Staphylococcus epidermidis (strain ATCC 12228) ... gi\|282876549\|ref... - pyruvate dehydrogenase E1 component, alpha subunit [Staphylococcus epidermidis SK135] gi\|293366919\|ref... - pyruvate dehydrogenase complex E1 component [Staphylococcus epidermidis M23864:W2(grey)]	284.0	[0..6]	[371..5]

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Predicted Domain #1

Region A:
Residues: [1-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKTKKAII DVKKQFEAVH KQFELVQILN EKGEIVNPDL MPDLTDDQLV ELMTRMVWTR  60
   61 VLDQRSISLN RQGRLGFYAP TAGQEASQLA SHYALEKHDY ILPGYRDVPQ LIWHGLPLTK 120
  121 AFLFSRGHFV GNQFPEDLNV LSPQIIIGAQ IVQAAGVALG LKKRKKDAVV ITYTGDGGSS 180
  181 QGDFYEGMNF AGAYHAPAIF VVQNNKFAIS TPREKQSAAE TLAQKAVAAG IPGVQVDGMD 240
  241 PLAVYAVTKF ARERAVAGEG PTLIETMTYR YGPHTLSGDD PTRYRTKELD GEWELKDPIV 300
  301 RFRTFLEGKG LWNEEKENAV IDQAKEEIKV AIKEADATPK QTVTDLLKNM YETPTAPIKE 360
  361 QLAIYEAKES K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.0
Match:	1w85A
Description:	The crystal structure of pyruvate deydrogenase E1 bound to the peripheral subunit binding domain of E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.58421424158131	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: