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View Structure Prediction Details

Protein: AFG3L2
Organism: Homo sapiens
Length: 797 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AFG3L2.

Description E-value Query
Range
Subject
Range
gi|114672121 - gi|114672121|ref|XP_512199.2| PREDICTED: AFG3 ATPase family gene 3-like 2 isoform 3 [Pan troglodytes...
0.0 [1..780] [1..780]
AFG3L2 - AFG3 ATPase family gene 3-like 2 (yeast)
0.0 [1..780] [1..780]
gi|73962221 - gi|73962221|ref|XP_547682.2| PREDICTED: similar to AFG3-like protein 2 (Paraplegin-like protein) [Ca...
0.0 [1..797] [1..798]
gi|109121514 - gi|109121514|ref|XP_001094032.1| PREDICTED: AFG3 ATPase family gene 3-like 2 isoform 1 [Macaca mulat...
0.0 [1..780] [1..781]
AFG32_MOUSE - AFG3-like protein 2 OS=Mus musculus GN=Afg3l2 PE=1 SV=1
0.0 [1..780] [1..779]
gi|109507457, gi... - ref|XP_225866.2| similar to 2310036I02Rik protein [Rattus norvegicus], gi|198442897|ref|NP_001128336...
0.0 [1..780] [1..779]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHRCLRLWG RGGCWPRGLQ QLLVPGGVGP GEQPCLRTLY RFVTTQARAS RNSLLTDIIA  60
   61 AYQRFCSRPP KGFEKYFPNG KNGKKASEPK EVMGEKKESK PAATTRSSGG GGGGGGKRGG 120
  121 KKDDSHWWSR FQKGDIPWDD KDFRMFFLWT ALFWGGVMFY LL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.993
Match: 1qd7B
Description: 30S subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [163-295]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKRSGREITW KDFVNNYLSK GVVDRLEVVN KRFVRVTFTP GKTPVDGQYV WFNIGSVDTF  60
   61 ERNLETLQQE LGIEGENRVP VVYIAESDGS FLLSMLPTVL IIAFLLYTIR RGPAGIGRTG 120
  121 RGMGGLFSVG ETT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [296-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKVLKDEIDV KFKDVAGCEE AKLEIMEFVN FLKNPKQYQD LGAKIPKGAI LTGPPGTGKT  60
   61 LLAKATAGEA NVPFITVSGS EFLEMFVGVG PARVRDLFAL ARKNAPCILF IDEIDAVGRK 120
  121 RGRGNFGGQS EQENTLNQLL VEMDGFNTTT NVVILAGTNR PDILDPALLR PGRFDRQIFI 180
  181 GPPDIKGRAS IFKVHLRPLK LDSTLEKDKL ARKLASLTPG FSGADVANVC NEAALIAARH 240
  241 LSDSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.39794
Match: 1lv7A
Description: AAA domain of cell division protein FtsH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.32318595170495 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.945162431169109 bayes_pls_golite062009
cation transmembrane transporter activity 0.651147541256606 bayes_pls_golite062009
purine nucleotide binding 0.428373955572763 bayes_pls_golite062009
purine ribonucleotide binding 0.424644011903671 bayes_pls_golite062009
ribonucleotide binding 0.424583288440993 bayes_pls_golite062009
nucleotide binding 0.422354428195324 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.343417528390083 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.340322591037813 bayes_pls_golite062009
pyrophosphatase activity 0.337450879590656 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.31055462644917 bayes_pls_golite062009
nucleic acid binding 0.192553066860219 bayes_pls_golite062009
cation-transporting ATPase activity 0.178480894611265 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
signal transducer activity 0.0529006651532686 bayes_pls_golite062009
molecular transducer activity 0.0529006651532686 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 0.0523354130179299 bayes_pls_golite062009
ATP binding 0.04834397972685 bayes_pls_golite062009
adenyl ribonucleotide binding 0.0149501427627318 bayes_pls_golite062009
adenyl nucleotide binding 0.00365326483311895 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [541-640]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQKHFEQAIE RVIGGLEKKT QVLQPEEKKT VAYHEAGHAV AGWYLEHADP LLKVSIIPRG  60
   61 KGLGYAQYLP KEQYLYTKEQ LLDRMCMTLG GRVSEEIFFG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.47
Match: 2di4A
Description: No description for 2di4A was found.

Predicted Domain #5
Region A:
Residues: [641-797]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RITTGAQDDL RKVTQSAYAQ IVQFGMNEKV GQISFDLPRQ GDMVLEKPYS EATARLIDDE  60
   61 VRILINDAYK RTVALLTEKK ADVEKVALLL LEKEVLDKND MVELLGPRPF AEKSTYEEFV 120
  121 EGTGSLDEDT SLPEGLKDWN KEREKEKEEP PGEKVAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.69897
Match: 2ce7A
Description: EDTA treated
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle