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View Structure Prediction Details

Protein: gi|187252543
Organism: synthetic construct
Length: 754 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|187252543.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
0.0 [10..745] [2171..2882]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
0.0 [95..753] [576..1235]
gi|109041177 - gi|109041177|ref|XP_001105310.1| PREDICTED: zinc finger protein 197 [Macaca mulatta]
0.0 [10..752] [205..963]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL  60
   61 CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE 120
  121 SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH 180
  181 LEPPYDPGTH HLPSGDFAQC TS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.07
Match: 2fi2A
Description: Solution structure of the SCAN homodimer from MZF-1/ZNF42
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.97572076253445 bayes_pls_golite062009
DNA binding 3.38941894783956 bayes_pls_golite062009
nucleic acid binding 3.3197625917842 bayes_pls_golite062009
transcription factor activity 2.69648667931275 bayes_pls_golite062009
transcription activator activity 2.64323093360221 bayes_pls_golite062009
binding 2.59742365390538 bayes_pls_golite062009
transcription repressor activity 2.1174449104536 bayes_pls_golite062009
protein binding 1.91815434972195 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.797371870302703 bayes_pls_golite062009
transcription corepressor activity 0.101314838383672 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [203-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVPTLPQVGN SGDQAGATVL RMVRPQDTVA YEDLSVDYTQ KKWKSLTLSQ RALQWNMMPE  60
   61 NHHSMASLAG ENMM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [277-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSELTPKQE FFKGSESSNR TSGGLFGVVP GAAETGDVCE DTFKELEGQT SDEEGSRLEN  60
   61 DFLEITDEDK KKSTKDRYDK YKEVGEHPPL SSSPVEHEGV LKGQKSYRCD ECGKAFNRSS 120
  121 HLIGHQRIHT GEKPYECNEC GKTFRQTSQL IVHLRTHTGE KPYECSECGK AYRHSSHLIQ 180
  181 HQRLHNGEKP YKCNECAKAF TQSSRLTDHQ RTHTGEK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 7.9
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [494-676]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYECNECGEA FIRSKSLARH QVLHTGKKPY KCNECGRAFC SNRNLIDHQR IHTGEKPYEC  60
   61 SECGKAFSRS KCLIRHQSLH TGEKPYKCSE CGKAFNQNSQ LIEHERIHTG EKPFECSECG 120
  121 KAFGLSKCLI RHQRLHTGEK PYKCNECGKS FNQNSHLIIH QRIHTGEKPY ECNECGKVFS 180
  181 YSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #5
Region A:
Residues: [677-754]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLMVHQRTHT GEKPYKCNDC GKAFSDSSQL IVHQRVHTGE KPYECSECGK AFSQRSTFNH  60
   61 HQRTHTGEKS SGLAWSVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1f2iG
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle