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View Structure Prediction Details

Protein: gi|187252543
Organism: synthetic construct
Length: 754 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|187252543.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
0.0 [10..745] [2171..2882]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
0.0 [95..753] [576..1235]
gi|109041177 - gi|109041177|ref|XP_001105310.1| PREDICTED: zinc finger protein 197 [Macaca mulatta]
0.0 [10..752] [205..963]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL  60
   61 CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE 120
  121 SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH 180
  181 LEPPYDPGTH HLPSGDFAQC TS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.07
Match: 2fi2A
Description: Solution structure of the SCAN homodimer from MZF-1/ZNF42
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.97572076253445 bayes_pls_golite062009
DNA binding 3.38941894783956 bayes_pls_golite062009
nucleic acid binding 3.3197625917842 bayes_pls_golite062009
transcription factor activity 2.69648667931275 bayes_pls_golite062009
transcription activator activity 2.64323093360221 bayes_pls_golite062009
binding 2.59742365390538 bayes_pls_golite062009
transcription repressor activity 2.1174449104536 bayes_pls_golite062009
protein binding 1.91815434972195 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.797371870302703 bayes_pls_golite062009
transcription corepressor activity 0.101314838383672 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [203-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVPTLPQVGN SGDQAGATVL RMVRPQDTVA YEDLSVDYTQ KKWKSLTLSQ RALQWNMMPE  60
   61 NHHSMASLAG ENMM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [277-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSELTPKQE FFKGSESSNR TSGGLFGVVP GAAETGDVCE DTFKELEGQT SDEEGSRLEN  60
   61 DFLEITDEDK KKSTKDRYDK YKEVGEHPPL SSSPVEHEGV LKGQKSYRCD ECGKAFNRSS 120
  121 HLIGHQRIHT GEKPYECNEC GKTFRQTSQL IVHLRTHTGE KPYECSECGK AYRHSSHLIQ 180
  181 HQRLHNGEKP YKCNECAKAF TQSSRLTDHQ RTHTGEK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 7.9
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [494-676]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYECNECGEA FIRSKSLARH QVLHTGKKPY KCNECGRAFC SNRNLIDHQR IHTGEKPYEC  60
   61 SECGKAFSRS KCLIRHQSLH TGEKPYKCSE CGKAFNQNSQ LIEHERIHTG EKPFECSECG 120
  121 KAFGLSKCLI RHQRLHTGEK PYKCNECGKS FNQNSHLIIH QRIHTGEKPY ECNECGKVFS 180
  181 YSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #5
Region A:
Residues: [677-754]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLMVHQRTHT GEKPYKCNDC GKAFSDSSQL IVHQRVHTGE KPYECSECGK AFSQRSTFNH  60
   61 HQRTHTGEKS SGLAWSVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1f2iG
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle