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View Structure Prediction Details

Protein: gi|208966442, gi...
Organism: synthetic construct
Length: 536 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|208966442, gi....

Description E-value Query
Range
Subject
Range
gi|76625539 - gi|76625539|ref|XP_587710.2| PREDICTED: similar to Heat shock factor protein 2 (HSF 2) (Heat shock t...
0.0 [1..536] [66..599]
HSF2_MOUSE - Heat shock factor protein 2 OS=Mus musculus GN=Hsf2 PE=2 SV=2
0.0 [1..536] [1..535]
gi|73946305 - gi|73946305|ref|XP_533482.2| PREDICTED: similar to Heat shock factor protein 2 (HSF 2) (Heat shock t...
0.0 [30..536] [73..578]
gi|111305869, gi... - gi|118764049|gb|AAI28421.1| HSF2 protein [Homo sapiens], gi|111305869|gb|AAI21051.1| HSF2 protein [H...
0.0 [1..536] [1..518]
gi|109072831 - gi|109072831|ref|XP_001108944.1| PREDICTED: heat shock transcription factor 2 isoform 1 [Macaca mula...
0.0 [1..517] [1..517]
gi|13928966, gi|... - gi|5764553|gb|AAD51329.1|AF172640_1 heat shock factor 2 [Rattus norvegicus], gi|55778284|gb|AAH86554...
0.0 [1..536] [1..513]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP KYFKHNNMAS  60
   61 FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0360186926687502 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQDDLLENIK RKVSSSKPEE NKIRQEDLTK IISSAQKVQI KQETIESRLS ELKSENESLW  60
   61 KEVSELRAKH AQQQQVIRKI VQFIVTLVQN NQLVSLKRKR PLL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 8.60206
Match: PF00447.8
Description: No description for PF00447.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [202-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNTNGAQKKN LFQHIVKEPT DNHHHKVPHS RTEGLKPRER ISDDIIIYDV TDDNADEENI  60
   61 PVIPETNEDV ISDPSNCSQY PDIVIVEDDN EDEYAPVIQS GEQNEPARES LSSGSDGSSP 120
  121 LMSSAVQLNG SSSLTSEDPV TMMDSILNDN INLL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [356-536]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKVELLDYLD SIDCSLEDFQ AMLSGRQFSI DPDLLVDLFT SSVQMNPTDY INNTKSENKG  60
   61 LETTKNNVVQ PVSEEGRKSK SKPDKQLIQY TAFPLLAFLD GNPASSVEQA STTASSEVLS 120
  121 SVDKPIEVDE LLDSSLDPEP TQSKLVRLEP LTEAEASEAT LFYLCELAPA PLDSDMPLLD 180
  181 S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle