YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190408648
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	551 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190408648.

Description	E-value	Query Range	Subject Range
gi\|190408648 - gi\|190408648\|gb\|EDV11913.1\| bud emergence protein 1 [Saccharomyces cerevisiae RM11-1a] gi\|151946588 - gi\|151946588\|gb\|EDN64810.1\| bud emergence protein [Saccharomyces cerevisiae YJM789] gi\|207347574 - gi\|207347574\|gb\|EDZ73700.1\| YBR200Wp-like protein [Saccharomyces cerevisiae AWRI1631] BEM1_YEAST - Bud emergence protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BEM1 PE=1 SV=1 BEM1 - Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions ...	0.0	[1..551]	[1..551]
scd2 - scaffold protein Scd2 SCD2_SCHPO - Protein scd2/ral3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=scd2 PE=3 SV=1	3.0E-79	[69..511]	[21..492]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	3.0E-68	[7..366]	[249..618]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5 gi\|210189 - gi\|210189\|gb\|AAA42565.1\| src-p60 phosphoprotein SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...	6.0E-67	[7..366]	[3..372]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...	2.0E-66	[7..366]	[3..372]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4	2.0E-66	[7..366]	[3..372]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-66	[7..366]	[3..372]
gi\|210265 - gi\|210265\|gb\|AAA42583.1\| p66-src protein gi\|394713 - gi\|394713\|emb\|CAA36156.1\| src protein [Avian sarcoma virus] SRC_AVIS2 - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain PR2257) GN=V-SRC PE=...	3.0E-66	[7..366]	[3..372]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...	5.0E-66	[7..366]	[3..372]

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Predicted Domain #1

Region A:
Residues: [1-66]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKNFKLSKR DSNGSKGRIT SADISTPSHD NGSVIKHIKT VPVRYLSSSS TPVKSQRDSS  60
   61 PKNRHN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	3.12724619324809	bayes_pls_golite062009
signal transducer activity	2.5284324342567	bayes_pls_golite062009
molecular transducer activity	2.5284324342567	bayes_pls_golite062009
protein binding	2.14586566310919	bayes_pls_golite062009
molecular adaptor activity	1.33740973673697	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.2323381312171	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
cytoskeletal protein binding	0.83493091348808	bayes_pls_golite062009
actin filament binding	0.75424908168927	bayes_pls_golite062009
transcription regulator activity	0.540818657754841	bayes_pls_golite062009
enzyme regulator activity	0.456661966897198	bayes_pls_golite062009
nucleic acid binding	0.352421112301971	bayes_pls_golite062009
DNA binding	0.281643350069021	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [67-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDITSPEKV IKAKYSYQAQ TSKELSFMEG EFFYVSGDEK DWYKASNPST GKEGVVPKTY  60
   61 FEVFDRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.24799
Match:	2ptk__
Description:	c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [134-238]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPSSVNGSNS SSRKVTNDSL NMGSLYAIVL YDFKAEKADE LTTYVGENLF ICAHHNCEWF  60
   61 IAKPIGRLGG PGLVPVGFVS IIDIATGYAT GNDVIEDIKS VNLPT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.24799
Match:	2ptk__
Description:	c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.24212855645397	bayes_pls_golite062009
protein binding	1.04550817342273	bayes_pls_golite062009
signal transducer activity	0.639296022362811	bayes_pls_golite062009
molecular transducer activity	0.639296022362811	bayes_pls_golite062009
GTPase regulator activity	0.459633124432679	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.457933659119243	bayes_pls_golite062009
small GTPase regulator activity	0.390993828682912	bayes_pls_golite062009
enzyme regulator activity	0.217422685675578	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.187012142094005	bayes_pls_golite062009
protein serine/threonine kinase activity	0.0693380673720717	bayes_pls_golite062009
protein kinase activity	0.0278354564906339	bayes_pls_golite062009
kinase activity	0.00999242592237526	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [239-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQEWKSNIAR YKASNISLGS VEQQQQQSIT KPQNKSAKLV DGELLVKASV ESFGLEDEKY  60
   61 WFLVCCELSN GKTRQLKRYY QDFYDLQVQL LDAFPAEAGK LRDAGGQWSK RIMPYIPGPV 120
  121 PYVTNSIT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.24799
Match:	2ptk__
Description:	c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [367-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRKEDLNIY VADLVNLPDY ISRSEMVHSL FVVLNNGFDR EFERDENQNN IKTLQENDTA  60
   61 TFATASQT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.156545
Match:	1gd5A_
Description:	p47phox NADPH oxidase
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [435-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNFASTNQDN TLTGEDLKLN KKLSDLSLSG SKQAPAQSTS GLKTTKIKFY YKDDIFALML  60
   61 KGDTTYKELR SKIAPRIDTD NFKLQTKLFD GSGEEIKTDS QVSNIIQAKL KISVHDI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	405.144602
Match:	1ip9A_
Description:	Bud emergence mediator Bemp1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: