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View Structure Prediction Details

Protein: gi|190691513, gi...
Organism: synthetic construct
Length: 922 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190691513, gi....

Description E-value Query
Range		 Subject
Range
gi|109086865 - gi|109086865|ref|XP_001083173.1| PREDICTED: similar to WW domain containing E3 ubiquitin protein lig...
 0.0 [1..922] [1..922]
gi|57107819 - gi|57107819|ref|XP_535119.1| PREDICTED: similar to WW domain containing E3 ubiquitin protein ligase ...
 0.0 [1..922] [1..922]
gi|60654423 - gi|60654423|gb|AAX29902.1| WW domain-containing protein 1 [synthetic construct]
 0.0 [1..922] [1..922]
gi|114620802 - gi|114620802|ref|XP_519843.2| PREDICTED: hypothetical protein isoform 6 [Pan troglodytes]
 0.0 [1..922] [1..922]

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Predicted Domain #1
Region A:
Residues: [1-161] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS  60
   61 NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 120
  121 LSLENKNGIA QTGELTVVLD GLVIEQENIT NCSSSPTIEI Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 2nq3A
Description: No description for 2nq3A was found.

Predicted functions:

Term Confidence Notes
binding 2.77482286467294 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
phospholipid binding 1.01018855528345 bayes_pls_golite062009
transporter activity 0.739583681946393 bayes_pls_golite062009
cation binding 0.706291776571458 bayes_pls_golite062009
metal ion binding 0.706291776571458 bayes_pls_golite062009
ion binding 0.699544466409876 bayes_pls_golite062009
hydrolase activity 0.501946993060588 bayes_pls_golite062009
calcium-dependent phospholipid binding 0.368277796845269 bayes_pls_golite062009
substrate-specific transporter activity 0.203141170126034 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [162-329] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENGDALHENG EPSARTTARL AVEGTNGIDN HVPTSTLVQN SCCSYVVNGD NTPSSPSQVA  60
   61 ARPKNTPAPK PLASEPADDT VNGESSSFAP TDNASVTGTP VVSEENALSP NCTSTTVEDP 120
  121 PVQEILTSSE NNECIPSTSA ELESEARSIL EPDTSNSRSS SAFEAAKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [330-441] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQPDGCMDPV RQQSGNANTE TLPSGWEQRK DPHGRTYYVD HNTRTTTWER PQPLPPGWER  60
   61 RVDDRRRVYY VDHNTRTTTW QRPTMESVRN FEQWQSQRNQ LQGAMQQFNQ RY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
proline-rich region binding 5.59283271741484 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
transcription regulator activity 3.2682543222543 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
transcription activator activity 2.28375305944516 bayes_pls_golite062009
transcription factor binding 2.18630749239417 bayes_pls_golite062009
transcription cofactor activity 2.07432061489599 bayes_pls_golite062009
transcription coactivator activity 2.02433252968502 bayes_pls_golite062009
ligase activity 1.93278509588727 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
transcription repressor activity 1.81795522051605 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
transcription corepressor activity 0.911388717587011 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [442-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYSASMLAAE NDPYGPLPPG WEKRVDSTDR VYFVNHNTKT TQWEDPRTQG LQNEEPLPEG  60
   61 WEIRYTREGV RYFVDHNTRT TTFKDPRNGK SS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.43
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.10194828712949 bayes_pls_golite062009
small conjugating protein ligase activity 6.82547847405261 bayes_pls_golite062009
acid-amino acid ligase activity 6.04482261304601 bayes_pls_golite062009
proline-rich region binding 5.1818611307601 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.16615441408338 bayes_pls_golite062009
transcription regulator activity 3.182048695645 bayes_pls_golite062009
binding 2.56070278040924 bayes_pls_golite062009
transcription activator activity 2.05338377709657 bayes_pls_golite062009
transcription factor binding 1.94857953695695 bayes_pls_golite062009
ligase activity 1.92115554795958 bayes_pls_golite062009
transcription cofactor activity 1.79381302696181 bayes_pls_golite062009
transcription repressor activity 1.7678419433602 bayes_pls_golite062009
transcription coactivator activity 1.67777735708173 bayes_pls_golite062009
histone methyltransferase activity 1.67021314973391 bayes_pls_golite062009
protein binding 1.37024347977003 bayes_pls_golite062009
protein methyltransferase activity 0.9455445085372 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
transcription corepressor activity 0.782679886083722 bayes_pls_golite062009
catalytic activity 0.231344568578849 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [534-922] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTKGGPQIAY ERGFRWKLAH FRYLCQSNAL PSHVKINVSR QTLFEDSFQQ IMALKPYDLR  60
   61 RRLYVIFRGE EGLDYGGLAR EWFFLLSHEV LNPMYCLFEY AGKNNYCLQI NPASTINPDH 120
  121 LSYFCFIGRF IAMALFHGKF IDTGFSLPFY KRMLSKKLTI KDLESIDTEF YNSLIWIRDN 180
  181 NIEECGLEMY FSVDMEILGK VTSHDLKLGG SNILVTEENK DEYIGLMTEW RFSRGVQEQT 240
  241 KAFLDGFNEV VPLQWLQYFD EKELEVMLCG MQEVDLADWQ RNTVYRHYTR NSKQIIWFWQ 300
  301 FVKETDNEVR MRLLQFVTGT CRLPLGGFAE LMGSNGPQKF CIEKVGKDTW LPRSHTCFNR 360
  361 LDLPPYKSYE QLKEKLLFAI EETEGFGQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.0
Match: 1nd7A
Description: Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 11.7414753295465 bayes_pls_golite062009
small conjugating protein ligase activity 11.4871643691645 bayes_pls_golite062009
acid-amino acid ligase activity 10.4323719338452 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 9.13168684685485 bayes_pls_golite062009
proline-rich region binding 6.0804245761416 bayes_pls_golite062009
phosphothreonine binding 5.90497053948475 bayes_pls_golite062009
phosphoserine binding 5.90497053948475 bayes_pls_golite062009
ligase activity 5.34807997732606 bayes_pls_golite062009
sodium channel inhibitor activity 2.81182200437095 bayes_pls_golite062009
binding 2.51893471705946 bayes_pls_golite062009
transcription regulator activity 2.32249912875549 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
DNA binding 1.96906809911381 bayes_pls_golite062009
nucleic acid binding 1.82016488092232 bayes_pls_golite062009
protein binding 1.39373180706125 bayes_pls_golite062009
transcription repressor activity 1.38110732864799 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
transcription factor binding 0.803487897091874 bayes_pls_golite062009
ubiquitin binding 0.60123113960943 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.598436219078807 bayes_pls_golite062009
small conjugating protein binding 0.33937847204197 bayes_pls_golite062009
sodium channel regulator activity 0.325435827772996 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009
transcription activator activity 0.0310258834625421 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle