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View Structure Prediction Details

Protein: gi|162319354, gi...
Organism: synthetic construct
Length: 885 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|162319354, gi....

Description E-value Query
Range
Subject
Range
gi|60729567 - gi|60729567|pir||JC7898 3',5'-cyclic nucleotide phosphodiesterase (EC 3.1.4.17) 8B1 - human
0.0 [1..885] [1..885]
gi|114599522 - gi|114599522|ref|XP_517695.2| PREDICTED: phosphodiesterase 8B [Pan troglodytes]
0.0 [118..885] [140..907]
gi|73952371 - gi|73952371|ref|XP_546056.2| PREDICTED: similar to phosphodiesterase 8B isoform 1 [Canis familiaris]
0.0 [129..885] [80..836]
gi|76626448 - gi|76626448|ref|XP_589274.2| PREDICTED: similar to phosphodiesterase 8B isoform 1 [Bos taurus]
0.0 [116..885] [1..770]
gi|40538865, gi|... - gi|40538865|ref|NP_954889.1| phosphodiesterase 8B [Rattus norvegicus], gi|38093208|dbj|BAD00195.1| c...
0.0 [125..885] [1..761]
gi|109077873 - gi|109077873|ref|XP_001101740.1| PREDICTED: similar to phosphodiesterase 8B isoform 1 [Macaca mulatt...
0.0 [231..885] [98..752]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG  60
   61 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 2c2aA
Description: Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [109-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSVKQVSSA EVRIGPMRLT QDPIQVLLIF AKEDSQSDGF WWACDRAGYR CNIARTPESA  60
   61 LECFLDKHHE IIVIDHRQTQ NFDAEAVCRS IRATNPSEHT VILAVVSRVS DDHEEASVLP 120
  121 LLHAGFNRRF MENSSIIACY NELIQIEHGE VRSQFKLRAC NSVFTALDHC HEAIEITSDD 180
  181 HVIQYVNPAF ERMMGYHKGE LLGKELADLP KSDKNRADLL DTINTCIKKG KEWQGVYYAR 240
  241 RKSGDSIQQH VKITPVIGQG GKIRHFVSLK KLCCTTDNNK QIHKIH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2gwrA
Description: No description for 2gwrA was found.

Predicted Domain #3
Region A:
Residues: [395-499]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSGDNSQTE PHSFRYKNRR KESIDVKSIS SRGSDAPSLQ NRRYPSMARI HSMTIEAPIT  60
   61 KVINIINAAQ ENSPVTVAEA LDRVLEILRT TELYSPQLGT KDEDP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [500-885]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTSDLVGGLM TDGLRRLSGN EYVFTKNVHQ SHSHLAMPIT INDVPPCISQ LLDNEESWDF  60
   61 NIFELEAITH KRPLVYLGLK VFSRFGVCEF LNCSETTLRA WFQVIEANYH SSNAYHNSTH 120
  121 AADVLHATAF FLGKERVKGS LDQLDEVAAL IAATVHDVDH PGRTNSFLCN AGSELAVLYN 180
  181 DTAVLESHHT ALAFQLTVKD TKCNIFKNID RNHYRTLRQA IIDMVLATEM TKHFEHVNKF 240
  241 VNSINKPMAA EIEGSDCECN PAGKNFPENQ ILIKRMMIKC ADVANPCRPL DLCIEWAGRI 300
  301 SEEYFAQTDE EKRQGLPVVM PVFDRNTCSI PKSQISFIDY FITDMFDAWD AFAHLPALMQ 360
  361 HLADNYKHWK TLDDLKCKSL RLPSDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 113.0
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3',5'-cyclic-nucleotide phosphodiesterase activity 4.72905094107626 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 4.61245226349897 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.65984874547256 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.3591603098704 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.96981753811593 bayes_pls_golite062009
hydrolase activity 1.22736412056595 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.511207383357891 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.432240759268351 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle