YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213425260
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. E02-1180
Length:	886 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213425260.

Description	E-value	Query Range	Subject Range
gi\|197361461, gi... - gi\|197361461\|ref\|YP_002141097.1\| putative acyl-CoA synthetase [Salmonella enterica subsp. enterica s... gi\|56412526, gi\|... - gi\|56412526\|ref\|YP_149601.1\| putative acyl-CoA synthetase [Salmonella enterica subsp. enterica serov... gi\|194401286, gi... - gi\|194442623\|ref\|YP_002041918.1\| CoA binding domain/acetyltransferase domain protein [Salmonella ent...	0.0	[1..886]	[1..886]
gi\|194408092, gi... - gi\|194449788\|ref\|YP_002046660.1\| CoA binding domain/acetyltransferase domain protein [Salmonella ent... gi\|168245085, gi... - gi\|205336131\|gb\|EDZ22895.1\| CoA binding domain/acetyltransferase domain protein [Salmonella enterica... lcl\|NC_016856.1_... - [gene=yfiQ] [protein=putative acetyl-CoA synthetase] [protein_id=YP_005238773.1] [location=2843714..... gi\|195628872, gi... - gi\|195628872\|gb\|EDX48286.1\| CoA binding domain/acetyltransferase domain protein [Salmonella enterica... gi\|161612629, gi... - gi\|161612629\|ref\|YP_001586594.1\| hypothetical protein SPAB_00324 [Salmonella enterica subsp. enteric... LYSAC_SALTY - Protein lysine acetyltransferase Pat OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)...	0.0	[1..886]	[1..886]
gi\|62128859, gi\|... - gi\|62181226\|ref\|YP_217643.1\| putative acetyl-CoA synthetase [Salmonella enterica subsp. enterica ser...	0.0	[1..886]	[1..886]
gi\|110616076, gi... - gi\|110806528\|ref\|YP_690048.1\| hypothetical protein SFV_2647 [Shigella flexneri 5 str. 8401], gi\|1106...	0.0	[1..886]	[1..886]
gi\|24053028, gi\|... - gi\|24113925\|ref\|NP_708435.1\| hypothetical protein SF2646 [Shigella flexneri 2a str. 301], gi\|2405302... gi\|30042241, gi\|... - gi\|30063985\|ref\|NP_838156.1\| hypothetical protein S2819 [Shigella flexneri 2a str. 2457T], gi\|300422...	0.0	[1..886]	[1..886]
gi\|170082193, gi... - gi\|170082193\|ref\|YP_001731513.1\| fused acyl-CoA synthetase: NAD(P)-binding subunit; ATP-binding subu... gi\|89109390, gi\|... - gi\|89109390\|ref\|AP_003170.1\| fused predicted acyl-CoA synthetase NAD(P)-binding subunit and ATP-bind... gi\|157067744, gi... - gi\|75196603\|ref\|ZP_00706673.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli HS], gi\|... YFIQ_ECOLI - Hypothetical protein yfiQ - Escherichia coli EG14224 - protein lysine acetyltransferase / Protein lysine acetyltransferase EG14224 - protein lysine acetyltransferase / Protein lysine acetyltransferase gi\|238901749, gi... - gi\|238901749\|ref\|YP_002927545.1\| fused putative acyl-CoA synthetase: NAD(P)-binding subunit/ATP-bind...	0.0	[1..886]	[1..886]
gi\|75178184, gi\|... - gi\|75178184\|ref\|ZP_00698243.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Shigella boydii BS512], g... gi\|81246450, gi\|... - gi\|82545039\|ref\|YP_408986.1\| hypothetical protein SBO_2616 [Shigella boydii Sb227], gi\|81246450\|gb\|A...	0.0	[1..886]	[1..886]
gi\|193068407, gi... - gi\|75237670\|ref\|ZP_00721686.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli E110019]... gi\|191167989, gi... - gi\|75228841\|ref\|ZP_00715442.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli B7A], gi... gi\|194429281, gi... - gi\|75209517\|ref\|ZP_00709742.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli B171], g... gi\|157079284, gi... - gi\|75187337\|ref\|ZP_00700604.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli E24377A]...	0.0	[1..886]	[1..886]
gi\|194437641, gi... - gi\|83586764\|ref\|ZP_00925395.1\| COG1042: Acyl-CoA synthetase (NDP forming) [Escherichia coli 101-1], ...	0.0	[1..886]	[1..886]
gi\|74313147, gi\|... - gi\|74313147\|ref\|YP_311566.1\| hypothetical protein SSON_2710 [Shigella sonnei Ss046], gi\|73856624\|gb\|...	0.0	[1..886]	[1..886]

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Predicted Domain #1

Region A:
Residues: [1-102]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQGLEALL RPKSIAVIGA SMKPHRAGYL MMRNLLAGGF NGPVLPVTPA WKAVLGVMAW  60
   61 PDIASLPFTP DLAILCTNAS RNLALLDALG AKGCKTCIIL SA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0
Match:	2csuA
Description:	No description for 2csuA was found.

Predicted Domain #2

Region A:
Residues: [103-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTSQHEELLA SARHYKMRLL GPNSLGLLAP WQGLNASFSP VPIKQGKLAF ISQSAAVSNT  60
   61 ILDWAQQREM GFSYFIALGD SLDIDVDELL DYLARDSKTS AILLYLEQLS DARRFVSAAR 120
  121 SASRNKPILV IKSGRSPAAQ RLLNTSAGMD PAWDAAIQRA GLLRVQDTHE LFSAVETLSH 180
  181 MRPLHGDRLM IISNGAAPAA LALDELWSRN GKLATLSEET CLQLRQTLPA HIDIANPLDL 240
  241 CDDASSEHYV KTLDILLASQ DFDALMVIHS PSAAAPGTES AHALIETIKR HPRGKFVTLL 300
  301 TNWCGEFSSQ EARRLFSEAG LPTYRTPEGT ITAFMHMVEY RRNQKQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.39794
Match:	2fp4B
Description:	Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	2.65834437588388	bayes_pls_golite062009
catalytic activity	2.5009559386228	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.03020006934407	bayes_pls_golite062009
CoA carboxylase activity	1.97356692026797	bayes_pls_golite062009
succinate-CoA ligase activity	1.97320026759321	bayes_pls_golite062009
CoA-ligase activity	1.70650205723619	bayes_pls_golite062009
acid-thiol ligase activity	1.65304911485061	bayes_pls_golite062009
ATP citrate synthase activity	1.64885390203992	bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity	1.55053478055591	bayes_pls_golite062009
acetyl-CoA carboxylase activity	1.47371551641074	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	1.34583813987229	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.474291950095735	bayes_pls_golite062009
biotin carboxylase activity	0.434630727705062	bayes_pls_golite062009
acid-amino acid ligase activity	0.311469287876404	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.239594107637156	bayes_pls_golite062009
glutathione synthase activity	0.158287661667506	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [450-682]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RETPALPSNL TSNTAEAHNL LQRAIAEGAT SLDTHEVQPI LHAYGLHTLP TWIASDSAEA  60
   61 VHIAEQIGYP VALKLRSPDI PHKSEVQGVM LYLRTASEVQ QAANAIFDRV KMAWPQARIH 120
  121 GLLVQSMANR AGAQELRVVV EHDPVFGPLI MLGEGGVEWR PEEQAVVALP PLNMNLARYL 180
  181 VIQGIKQRKI RARSALRPLD IVGLSQLLVQ VSNLIVDCPE IQRLDIHPLL ASA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.39794
Match:	1wr2A
Description:	Crystal structure of PH1788 from Pyrococcus horikoshii Ot3
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [683-886]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEFTALDVTL DIAPFDGDNE SRLAVRPYPH QLEEWVEMKN GDRCLFRPIL PEDEPQLRQF  60
   61 IAQVTKEDLY YRYFSEINEF THEDLANMTQ IDYDREMAFV AVRRMDNAEE ILGVTRAISD 120
  121 PDNVDAEFAV LVRSDLKGLG LGRRLMEKLI AYTRDHGLKR LNGITMPNNR GMVALARKLG 180
  181 FQVDIQLDEG IVGLTLNLAK CDES

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.30103
Match:	1w96A
Description:	Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: