YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|221313655
Organism:	Bacillus subtilis subsp. subtilis str. NCIB 3610
Length:	371 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|221313655.

Description	E-value	Query Range	Subject Range
gi\|255028745 - gi\|255028745\|ref\|ZP_05300696.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|255027445 - gi\|255027445\|ref\|ZP_05299431.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|254873306 - gi\|254873306\|ref\|ZP_05246016.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|47015490, gi\|... - gi\|47096141\|ref\|ZP_00233741.1\| pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase ... gi\|16803092 - gi\|16803092\|ref\|NP_464577.1\| hypothetical protein lmo1052 [Listeria monocytogenes EGD-e] gi\|284994526\|ref... - hypothetical protein LM5923_1089 [Listeria monocytogenes 08-5923] gi\|254898775, gi... - gi\|254898775\|ref\|ZP_05258699.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|16410454, gi\|... - pir\|\|AD1206 pyruvate dehydrogenase (E1 alpha chain) homolog pdhA [imported] - Listeria monocytogenes... gi\|127634131, gi... - gi\|254830179\|ref\|ZP_05234834.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|153190463, gi... - gi\|254911736\|ref\|ZP_05261748.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|153174118, gi... - gi\|254828429\|ref\|ZP_05233116.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|254936062, gi... - gi\|254936062\|ref\|ZP_05267759.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|217964855, gi... - gi\|217964855\|ref\|YP_002350533.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyt... gi\|224502634 - gi\|224502634\|ref\|ZP_03670941.1\| pyruvate dehydrogenase E1 component subunit alpha [Listeria monocyto... gi\|290893797\|ref... - pyruvate dehydrogenase complex [Listeria monocytogenes FSL J2-071] gi\|284801384\|ref... - hypothetical protein LM5578_1135 [Listeria monocytogenes 08-5578]	329.0	[0..1]	[371..1]

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Predicted Domain #1

Region A:
Residues: [1-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKTKKAIV DSKKQFDAIK KQFETFQILN EKGEVVNEAA MPDLTDDQLK ELMRRMVFTR  60
   61 VLDQRSISLN RQGRLGFYAP TAGQEASQIA THFALEKEDF VLPGYRDVPQ LIWHGLPLYQ 120
  121 AFLFSRGHFR GNQMPDDVNA LSPQIIIGAQ YIQTAGVALG LKKRGKKAVA ITYTGDGGAS 180
  181 QGDFYEGINF AGAYKAPAIF VVQNNRYAIS TPVEKQSAAE TIAQKAVAAG IVGVQVDGMD 240
  241 PLAVYAATAE ARERAINGEG PTLIETLTFR YGPHTMAGDD PTKYRTKEIE NEWEQKDPLV 300
  301 RFRAFLENKG LWSEEEEAKV IEDAKEEIKQ AIKKADAEPK QKVTDLMKIM YEKMPHNLEE 360
  361 QFEIYTQKES K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.045757
Match:	1w85A
Description:	The crystal structure of pyruvate deydrogenase E1 bound to the peripheral subunit binding domain of E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.53492491341322	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: