YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190406691
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	854 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190406691.

Description	E-value	Query Range	Subject Range
CDC24 - Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity est... gi\|190406691 - gi\|190406691\|gb\|EDV09958.1\| guanine nucleotide exchange factor for cdc42 [Saccharomyces cerevisiae R... CDC24_YEAST - Cell division control protein 24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC24 P...	0.0	[1..854]	[1..854]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[119..854]	[1..736]
gi\|11907611, gi\|... - gi\|45188261\|ref\|NP_984484.1\| ADR388Cp [Ashbya gossypii ATCC 10895], gi\|44983105\|gb\|AAS52308.1\| ADR38... gi\|44983105 - gi\|44983105\|gb\|AAS52308.1\| ADR388Cp [Ashbya gossypii ATCC 10895]	0.0	[23..851]	[14..757]
SCD1_SCHPO - Rho guanine nucleotide exchange factor scd1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... scd1 - RhoGEF Scd1	8.0E-94	[155..839]	[104..846]
gi\|6755268, gi\|5... - gi\|6755268\|ref\|NP_036008.1\| T-cell lymphoma invasion and metastasis 2 [Mus musculus], gi\|5264503\|dbj...	2.0E-88	[67..727]	[924..1585]
MCF2 - MCF.2 cell line derived transforming sequence	5.0E-86	[151..730]	[355..920]

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Predicted Domain #1

Region A:
Residues: [1-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI RKRLEVLPQL  60
   61 KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS SDLAPTLRSS SISTATSLMS 120
  121 MEGISYTNSN PSA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [134-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPNMEDTLLT FSMGILPITM DCDPVTQLSQ LFQQGAPLCI LFNSVKPQFK LPVIASDDLK  60
   61 VCKKSIYDFI LGCKKHFAFN DEELFTISDV FANSTSQLVK VLEVVETLMN SSPTIFPSKS 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1h67A_
Description:	Calponin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [254-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTQQIMNAEN QHRHQPQQSS KKHNEYVKII KEFVATERKY VHDLEILDKY RQQLLDSNLI  60
   61 TSEELYMLFP NLGDAIDFQR RFLISLEINA LVEPSKQRIG ALFMHSKHFF KLYEPWSIGQ 120
  121 NAAIEFLSST LHKMRVDESQ RFIINNKLEL QSFLYKPVQR LCRYPLLVKE LLAESSDDNN 180
  181 TKELEAALDI SKNIARSINE NQRRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	202.457575
Match:	1foeA_
Description:	GEF of TIAM1 (T-Lymphoma invasion and metastasis indusing protein 1)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [459-642]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENHQVVKKLY GRVVNWKGYR ISKFGELLYF DKVFISTTNS SSEPEREFEV YLFEKIIILF  60
   61 SEVVTKKSAS SLILKKKSST SASISASNIT DNNGSPHHSY HKRHSNSSSS NNIHLSSSSA 120
  121 AAIIHSSTNS SDNNSNNSSS SSLFKLSANE PKLDLRGRIM IMNLNQIIPQ NNRSLNITWE 180
  181 SIKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	202.457575
Match:	1foeA_
Description:	GEF of TIAM1 (T-Lymphoma invasion and metastasis indusing protein 1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [643-754]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGNFLLKFKN EETRDNWSSC LQQLIHDLKN EQFKARHHSS TSTTSSTAKS SSMMSPTTTM  60
   61 NTPNHHNSRQ THDSMASFSS SHMKRVSDVL PKRRTTSSSF ESEIKSISEN FK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.24212855645397	bayes_pls_golite062009
protein binding	1.04550817342273	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.993282922991536	bayes_pls_golite062009
kinase activity	0.682664093464385	bayes_pls_golite062009
signal transducer activity	0.639296022362811	bayes_pls_golite062009
molecular transducer activity	0.639296022362811	bayes_pls_golite062009
GTPase regulator activity	0.459633124432679	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.457933659119243	bayes_pls_golite062009
small GTPase regulator activity	0.390993828682912	bayes_pls_golite062009
enzyme regulator activity	0.217422685675578	bayes_pls_golite062009
protein serine/threonine kinase activity	0.0693380673720717	bayes_pls_golite062009
protein kinase activity	0.0278354564906339	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [755-854]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSIPESSILF RISYNNNSNN TSSSEIFTLL VEKVWNFDDL IMAINSKISN THNNNISPIT  60
   61 KIKYQDEDGD FVVLGSDEDW NVAKEMLAEN NEKFLNIRLY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.628	0.826	pheromone-dependent signal transduction involved in conjugation with cellular fusion	b.1.1	Immunoglobulin

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: