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View Structure Prediction Details

Protein: TIMP1_PONAB
Organism: Pongo abelii
Length: 207 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIMP1_PONAB.

Description E-value Query
Range		 Subject
Range
TIMP1_BOVIN - Metalloproteinase inhibitor 1 OS=Bos taurus GN=TIMP1 PE=1 SV=1
 2.0E-89 [1..207] [1..207]
TIMP1_PAPCY - Metalloproteinase inhibitor 1 OS=Papio cynocephalus GN=TIMP1 PE=2 SV=1
gi|1363927 - gi|1363927|pir||JC4303 matrix metalloproteinase-1 tissue inhibitor - baboon
 5.0E-88 [1..207] [1..207]
gi|61365717, gi|... - gi|61365717|gb|AAX42752.1| tissue inhibitor of metalloproteinase 1 [synthetic construct], gi|5469612...
 6.0E-88 [1..207] [1..207]
gi|2147195 - pir||I47061 collagenase inhibitor - pig
gi|247730, gi|47... - gi|47523144|ref|NP_999022.1| tissue inhibitor of metalloproteinase 1 [Sus scrofa], gi|247730|gb|AAB2...
 2.0E-87 [1..207] [1..207]
TIMP1_MACMU - Metalloproteinase inhibitor 1 OS=Macaca mulatta GN=TIMP1 PE=2 SV=1
 4.0E-87 [1..207] [1..207]
gi|31189 - gi|31189|emb|CAA26443.1| unnamed protein product [Homo sapiens]
 5.0E-87 [1..207] [1..207]
TIMP1_SHEEP - Metalloproteinase inhibitor 1 OS=Ovis aries GN=TIMP1 PE=2 SV=1
 6.0E-87 [1..207] [1..207]
TIMP1_HORSE - Metalloproteinase inhibitor 1 OS=Equus caballus GN=TIMP1 PE=2 SV=1
 5.0E-85 [1..207] [1..207]
TIMP1_CANLF - Metalloproteinase inhibitor 1 OS=Canis lupus familiaris GN=TIMP1 PE=1 SV=2
 2.0E-84 [1..207] [1..207]

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Predicted Domain #1
Region A:
Residues: [1-207] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP EVNQTTLYQR  60
   61 YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH NRSEEFLIAG KLQDGLLHIT 120
  121 TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK 180
  181 GFQSRHLACL PREPGLCTWQ SLRSQIA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.0
Match: 1ueaB
Description: TIMP-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metalloendopeptidase inhibitor activity 7.17434748400899 bayes_pls_golite062009
metalloenzyme regulator activity 7.17434748400899 bayes_pls_golite062009
metalloenzyme inhibitor activity 7.17434748400899 bayes_pls_golite062009
peptidase inhibitor activity 3.93668549411033 bayes_pls_golite062009
endopeptidase inhibitor activity 3.90361447859652 bayes_pls_golite062009
receptor binding 1.79096938850925 bayes_pls_golite062009
protein binding 1.78630177339498 bayes_pls_golite062009
enzyme inhibitor activity 1.54714635439345 bayes_pls_golite062009
binding 1.31216249528051 bayes_pls_golite062009
cytokine activity 1.02252345748708 bayes_pls_golite062009
chemokine activity 0.59253057522745 bayes_pls_golite062009
chemokine receptor binding 0.59253057522745 bayes_pls_golite062009
G-protein-coupled receptor binding 0.0664286291223601 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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