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View Structure Prediction Details

Protein: gi|14719761
Organism: Homo sapiens
Length: 160 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|14719761.

Description E-value Query
Range
Subject
Range
gi|6573558, gi|6... - gi|6573559|pdb|1CQT|B Chain B, Crystal Structure Of A Ternary Complex Containing An Oca-B Peptide, T...
153.0 [0..1] [160..4]
PO2F1_PIG - POU domain, class 2, transcription factor 1 OS=Sus scrofa GN=POU2F1 PE=2 SV=1
150.0 [0..1] [160..280]
gi|115497644, gi... - gi|115497644|ref|NP_001069050.1| POU class 2 homeobox 1 [Bos taurus], gi|111305157|gb|AAI20289.1| PO...
149.0 [0..1] [160..292]
gi|73960713 - gi|73960713|ref|XP_850943.1| PREDICTED: similar to POU domain, class 2, transcription factor 1 (Octa...
148.0 [0..1] [160..292]
PO2F1_XENTR - POU domain, class 2, transcription factor 1 OS=Xenopus tropicalis GN=pou2f1 PE=2 SV=1
148.0 [0..1] [160..294]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEPSDLEELE QFAKTFKQRR IKLGFTQGDV GLAMGKLYGN DFSQTTISRF EALNLSFKNM  60
   61 SKLKPLLEKW LNDAEANLSS DSSLSSPSAL NSPGIEGLSR RRKKRTSIET NIRVALEKSF 120
  121 MENQKPTSED ITLIAEQLNM EKEVIRVWFS NRRQKEKRIN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.69897
Match: 1e3oC
Description: Oct-1 POU Homeodomain; Oct-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22754992035091 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
chromatin binding 1.2739759748489 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.92393807212912 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
transcription coactivator activity 0.81316180547536 bayes_pls_golite062009
promoter binding 0.22765608166458 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle