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View Structure Prediction Details

Protein: gi|42572647
Organism: Arabidopsis thaliana
Length: 705 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|42572647.

Description E-value Query
Range
Subject
Range
gi|114560633 - gi|114560633|ref|XP_001171686.1| PREDICTED: nicastrin isoform 2 [Pan troglodytes]
568.0 [0..2] [705..14]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMGLIRLLS IAFTLVLLSI LPLHLSLADE ITSIESVPDL QKLMYVAVDG FPCVRLLNLS  60
   61 GEIGCS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [67-580]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPGINKVVAP IIKLKDVKDL VQPHTILVTA DEMEDFFTRV STDLSFASKI GGVLVESGSN  60
   61 FQQKLKGFSP DKRFPQAQFS PYENVEYKWN SAASSIMWRN YNFPVYLLSE SGISAVHEIL 120
  121 SKKKMKHGTY TSDVAEFNMV METTKAGTHN SEACLQEGTC LPLGGYSVWS SLPPISVSSS 180
  181 NNRKPVVLTV ASMDTASFFR DKSFGADSPI SGLVALLGAV DALSRVDGIS NLKKQLVFLV 240
  241 LTGETWGYLG SRRFLHELDL HSDAVAGLSN TSIETVLEIG SVGKGLSGGI NTFFAHKTRV 300
  301 SSVTNMTLDA LKIAQDSLAS KNIKILSADT ANPGIPPSSL MAFMRKNPQT SAVVLEDFDT 360
  361 NFVNKFYHSH LDDLCKKSHS LSFSSFRSKP HFALLIPFWC CIAANINSSS VVAAASVVAR 420
  421 TLYILASDNK DTSNSALGSI HVNASFVEEL LTCLLACEPG LSCNLVKDYI SPTNTCPGNY 480
  481 AGVILGEPSS KPYLGYVGDV SRFLWNFLAD KTSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.39794
Match: 1de4C
Description: Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 3.68442839136734 bayes_pls_golite062009
peptidase activity 3.64510404037841 bayes_pls_golite062009
receptor activity 3.43249110530054 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.26499474130077 bayes_pls_golite062009
hydrolase activity 2.98013991489506 bayes_pls_golite062009
signal transducer activity 2.61784313760368 bayes_pls_golite062009
molecular transducer activity 2.61784313760368 bayes_pls_golite062009
metallopeptidase activity 2.04062448553328 bayes_pls_golite062009
exopeptidase activity 1.70361627875478 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
metalloexopeptidase activity 0.950629204175701 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
binding 0.688905385320691 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
protein binding 0.00854198798870509 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [581-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKGNTTSVCS KGVCSKTDEV CIKAESNKEG TCVVSTTRYV PAYSTRLKYN DGAWTILPQN  60
   61 SSDSMGMVDP VWTESNWDTL RVHVYTVQHS AYDNAVLVAG ITVTTLAYIG ILAAKSIITK 120
  121 ALKQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle