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View Structure Prediction Details

Protein: gi|22218837
Organism: Homo sapiens
Length: 275 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|22218837.

Description E-value Query
Range
Subject
Range
gi|108743887 - gi|108743887|gb|ABG02212.1| MHC class I antigen [Pan troglodytes]
318.0 [0..2] [274..25]
gi|15808083 - gi|15808083|gb|AAK67484.1| MHC class I antigen [Pongo pygmaeus]
318.0 [0..2] [274..25]
gi|4468256 - gi|4468256|emb|CAB38057.1| MHC class I antigen [Homo sapiens]
314.0 [0..2] [274..25]

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Predicted Domain #1
Region A:
Residues: [1-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPHSLRYNL MVLSQDGSVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AEDVLGAETW  60
   61 DTETEDLTEN GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH EDSSTRGSRH FYYNGELFLS 120
  121 QNLETQESTV PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR 180
  181 RTVPPMVNVT CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG 240
  241 TYQTWVATRI RQGEEQRFTC YMEHSGNHGT HPVPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 1je6A
Description: Class I MHC homolog, alpha-3 domain; Class I MHC homolog
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptide antigen binding 11.0753660234769 bayes_pls_golite062009
olfactory receptor activity 10.396146040408 bayes_pls_golite062009
antigen binding 4.70353060278319 bayes_pls_golite062009
transmembrane receptor activity 4.47335611545936 bayes_pls_golite062009
receptor activity 4.41760011727341 bayes_pls_golite062009
endogenous lipid antigen binding 3.8178682806181 bayes_pls_golite062009
G-protein coupled receptor activity 3.81042605880111 bayes_pls_golite062009
molecular transducer activity 3.44808015198907 bayes_pls_golite062009
signal transducer activity 3.44808015198907 bayes_pls_golite062009
lipid antigen binding 3.36458164702861 bayes_pls_golite062009
natural killer cell lectin-like receptor binding 2.87337850935774 bayes_pls_golite062009
MHC class I receptor activity 2.8317290648207 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.64517375056633 bayes_pls_golite062009
IgG binding 2.59905791929203 bayes_pls_golite062009
peptide binding 2.55584703989799 bayes_pls_golite062009
protein binding 2.20481087437436 bayes_pls_golite062009
exogenous lipid antigen binding 2.20171675099945 bayes_pls_golite062009
receptor binding 2.03767222253534 bayes_pls_golite062009
immunoglobulin receptor activity 2.03064643363242 bayes_pls_golite062009
binding 1.90626658068048 bayes_pls_golite062009
fibroblast growth factor binding 1.78492923920341 bayes_pls_golite062009
growth factor binding 1.60826091835429 bayes_pls_golite062009
IgG receptor activity 1.15013317153047 bayes_pls_golite062009
nucleic acid binding 0.951547821168483 bayes_pls_golite062009
IgE binding 0.92099524949571 bayes_pls_golite062009
IgE receptor activity 0.92099524949571 bayes_pls_golite062009
coreceptor activity 0.661209696849389 bayes_pls_golite062009
cell adhesion molecule binding 0.63737386998612 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.447829399094714 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
DNA binding 0.32716145688038 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.28309679787333 bayes_pls_golite062009
MHC class II receptor activity 0.251167772391909 bayes_pls_golite062009
catalytic activity 0.115804452291889 bayes_pls_golite062009

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