YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|21730760, gi\|...
Organism:	Homo sapiens
Length:	160 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21730760, gi|....

Description	E-value	Query Range	Subject Range
gi\|197102444 - gi\|197102444\|ref\|NP_001126390.1\| von Hippel-Lindau tumor suppressor [Pongo abelii] gi\|55731296 - gi\|55731296\|emb\|CAH92362.1\| hypothetical protein [Pongo abelii]	270.0	[0..3]	[160..56]
VHL - von Hippel-Lindau tumor suppressor	268.0	[0..3]	[160..56]
VHL_CANLF - Von Hippel-Lindau disease tumor suppressor OS=Canis lupus familiaris GN=VHL PE=2 SV=1	268.0	[0..1]	[158..54]
gi\|76648503 - gi\|76648503\|ref\|XP_613870.2\| PREDICTED: similar to Von Hippel-Lindau disease tumor suppressor (pVHL)...	263.0	[0..1]	[158..29]
VHL_RAT - Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl PE=1 SV=1 gi\|1245912 - gi\|1245912\|gb\|AAB35675.1\| von Hippel-Lindau tumor suppressor gene homolog [Rattus sp.]	260.0	[0..1]	[160..20]
gi\|2143464, gi\|9... - gi\|913328\|gb\|AAB33363.1\| von Hippel-Lindau disease gene [Mus sp.], gi\|2143464\|pir\|\|I52731 gene mVHLh... VHL_MOUSE - Von Hippel-Lindau disease tumor suppressor OS=Mus musculus GN=Vhl PE=1 SV=1	252.0	[0..1]	[160..20]
gi\|163916476, gi... - gi\|62858543\|ref\|NP_001016367.1\| von Hippel-Lindau tumor suppressor [Xenopus (Silurana) tropicalis], ...	224.0	[0..8]	[160..12]
gi\|30387874 - gi\|30387874\|gb\|AAP32238.1\| von Hippel-Lindau tumor suppressor gene [Rattus sp.]	204.0	[0..12]	[134..1]
gi\|68362476 - gi\|68362476\|ref\|XP_686268.1\| PREDICTED: similar to Von Hippel-Lindau disease tumor suppressor (pVHL)...	200.0	[0..2]	[150..7]

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Predicted Domain #1

Region A:
Residues: [1-160]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAGRPRPVL RSVNSREPSQ VIFCNRSPRV VLPVWLNFDG EPQPYPTLPP GTGRRIHSYR  60
   61 GHLWLFRDAG THDGLLVNQT ELFVPSLNVD GQPIFANITL PVYTLKERCL QVVRSLVKPE 120
  121 NYRRLDIVRS LYEDLEDHPN VQKDLERLTQ ERIAHQRMGD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.0
Match:	1lqbC
Description:	VHL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	8.01440994441489	bayes_pls_golite062009
small conjugating protein ligase activity	7.70942209868927	bayes_pls_golite062009
acid-amino acid ligase activity	6.77439707091624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	5.6984967446785	bayes_pls_golite062009
ligase activity	2.91269442989189	bayes_pls_golite062009
binding	2.41295334316774	bayes_pls_golite062009
protein binding	2.1782543635871	bayes_pls_golite062009
transcription factor binding	2.06418606532911	bayes_pls_golite062009
catalytic activity	0.334765053110546	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: