YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|1633235, gi\|1...
Organism:	Geobacillus stearothermophilus
Length:	455 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|1633235, gi|1....

Description	E-value	Query Range	Subject Range
DLDH1_GEOSE - Dihydrolipoyl dehydrogenase OS=Geobacillus stearothermophilus GN=pdhD PE=1 SV=2	422.0	[0..1]	[455..7]
gi\|56419596, gi\|... - gi\|56419596\|ref\|YP_146914.1\| dihydrolipoamide dehydrogenase [Geobacillus kaustophilus HTA426], gi\|56...	421.0	[0..1]	[455..7]
gi\|25284909 - pir\|\|D83981 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase) pdhD [imported] - Bacillus ha... gi\|10175273, gi\|... - gi\|15615215\|ref\|NP_243518.1\| dihydrolipoamide dehydrogenase [Bacillus halodurans C-125], gi\|10175273...	416.0	[0..1]	[455..7]
gi\|56964182, gi\|... - gi\|56964182\|ref\|YP_175913.1\| dihydrolipoamide dehydrogenase [Bacillus clausii KSM-K16], gi\|56910425\|...	415.0	[0..1]	[455..7]
gi\|89085673, gi\|... - gi\|89099520\|ref\|ZP_01172395.1\| dihydrolipoamide dehydrogenase [Bacillus sp. NRRL B-14911], gi\|890856...	414.0	[0..2]	[455..8]
gi\|91762636, gi\|... - gi\|91762636\|ref\|ZP_01264601.1\| Dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1002]...	413.0	[0..1]	[452..2]
gi\|71062053, gi\|... - gi\|71082940\|ref\|YP_265659.1\| dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1062], ...	412.0	[0..1]	[452..2]
gi\|221313658 - gi\|221313658\|ref\|ZP_03595463.1\| dihydrolipoamide dehydrogenase [Bacillus subtilis subsp. subtilis st... DLDH1_BACSU - Dihydrolipoyl dehydrogenase OS=Bacillus subtilis (strain 168) GN=pdhD PE=3 SV=1 DLDH1_BACSU, DLD... - Dihydrolipoyl dehydrogenase OS=Bacillus subtilis GN=pdhD PE=3 SV=1, (P21880) Dihydrolipoyl dehydroge... gi\|221318580 - gi\|221318580\|ref\|ZP_03599874.1\| dihydrolipoamide dehydrogenase [Bacillus subtilis subsp. subtilis st... gi\|221322854 - gi\|221322854\|ref\|ZP_03604148.1\| dihydrolipoamide dehydrogenase [Bacillus subtilis subsp. subtilis st...	412.0	[0..2]	[455..8]
gi\|227892434, gi... - gi\|227892434\|ref\|ZP_04010239.1\| dihydrolipoamide dehydrogenase [Lactobacillus salivarius ATCC 11741]... gi\|90820332, gi\|... - gi\|90961138\|ref\|YP_535054.1\| dihydrolipoamide dehydrogenase [Lactobacillus salivarius UCC118], gi\|90...	402.0	[0..1]	[455..7]
gi\|72495517, gi\|... - gi\|73663002\|ref\|YP_301783.1\| dihydrolipoamide dehydrogenase [Staphylococcus saprophyticus subsp. sap...	401.0	[0..2]	[455..8]

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Predicted Domain #1

Region A:
Residues: [1-455]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIETETLVVG AGPGGYVAAI RAAQLGQKVT IVEKGNLGGV CLNVGCIPSK ALISASHRYE  60
   61 QAKHSEEMGI KAENVTIDFA KVQEWKASVV KKLTGGVEGL LKGNKVEIVK GEAYFVDANT 120
  121 VRVVNGDSAQ TYTFKNAIIA TGSRPIELPN FKFSNRILDS TGALNLGEVP KSLVVIGGGY 180
  181 IGIELGTAYA NFGTKVTILE GAGEILSGFE KQMAAIIKKR LKKKGVEVVT NALAKGAEER 240
  241 EDGVTVTYEA NGETKTIDAD YVLVTVGRRP NTDELGLEQI GIKMTNRGLI EVDQQCRTSV 300
  301 PNIFAIGDIV PGPALAHKAS YEGKVAAEAI AGHPSAVDYV AIPAVVFSDP ECASVGYFEQ 360
  361 QAKDEGIDVI AAKFPFAANG RALALNDTDG FLKLVVRKED GVIIGAQIIG PNASDMIAEL 420
  421 GLAIEAGMTA EDIALTIHAH PTLGEIAMEA AEVAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1ebdA
Description:	Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	8.07008457237017	bayes_pls_golite062009
lipoamide binding	7.21320397413054	bayes_pls_golite062009
pyruvate dehydrogenase activity	6.59152030973708	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.56425883527182	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	6.2758493127081	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	6.2758493127081	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	6.01050580930819	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	5.38255966064925	bayes_pls_golite062009
oxoglutarate dehydrogenase (succinyl-transferring) activity	5.32373368820399	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	5.18991258719053	bayes_pls_golite062009
NADH dehydrogenase activity	3.68406278988218	bayes_pls_golite062009
thioredoxin-disulfide reductase activity	3.42654162439464	bayes_pls_golite062009
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	3.35142373392777	bayes_pls_golite062009
oxidoreductase activity	3.19495080984613	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	3.15456908604913	bayes_pls_golite062009
glutathione binding	2.84679371365652	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.57282017498189	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.50603438449246	bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions	2.49798084628282	bayes_pls_golite062009
tubulin binding	2.40546880499445	bayes_pls_golite062009
microtubule binding	2.30064869971937	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.28982462439281	bayes_pls_golite062009
cytoskeletal protein binding	2.23446140524739	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.12515648558024	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	1.42994468012845	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
protein binding	1.16738144711505	bayes_pls_golite062009
transporter activity	0.890824576391732	bayes_pls_golite062009
transmembrane transporter activity	0.706117386114413	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.684108511779641	bayes_pls_golite062009
transferase activity	0.565295320107724	bayes_pls_golite062009
electron carrier activity	0.511623955786613	bayes_pls_golite062009
substrate-specific transporter activity	0.491481205015383	bayes_pls_golite062009
coenzyme binding	0.424849261981	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.26114823844682	bayes_pls_golite062009
succinate dehydrogenase activity	0.110826254138262	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: