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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classfier did not use Gene Ontology annotations. [FDR: 0.074] [SVM Score: 0.777035460007]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
DIS3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • mitochondrion
  • nuclear outer membrane
    		•
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
  • RNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    cytoplasmic exosome (RNase complex) 3.3348E-6 2 12 2 6292
    nuclear exosome (RNase complex) 5.3053E-6 2 15 2 6292
    exosome (RNase complex) 6.0632E-6 2 16 2 6292
    nuclear outer membrane 1.8468E-4 2 86 2 6292
    nuclear membrane 2.3525E-4 2 97 2 6292
    outer membrane 7.9595E-4 2 178 2 6292
    organelle outer membrane 7.9595E-4 2 178 2 6292
    nuclear envelope 9.9543E-4 2 199 2 6292
    nuclear membrane-endoplasmic reticulum network 1.3539E-3 2 232 2 6292
    endomembrane system 3.9918E-3 2 398 2 6292
    envelope 6.43E-3 2 505 2 6292
    organelle envelope 6.43E-3 2 505 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mRNA catabolic process 1.1854E-4 2 69 2 6292
    RNA catabolic process 1.5966E-4 2 80 2 6292
    mRNA metabolic process 1.1408E-3 2 213 2 6292
    cellular macromolecule catabolic process 1.7674E-3 2 265 2 6292
    macromolecule catabolic process 2.1762E-3 2 294 2 6292
    polyadenylation-dependent RNA catabolic process 2.5415E-3 2 8 1 6292
    polyadenylation-dependent ncRNA catabolic process 2.5415E-3 2 8 1 6292
    cellular catabolic process 4.3405E-3 2 415 2 6292
    catabolic process 6.2027E-3 2 496 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    3'-5'-exoribonuclease activity 1.2783E-5 2 23 2 6292
    exoribonuclease activity 1.6421E-5 2 26 2 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 1.6421E-5 2 26 2 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.8346E-5 2 34 2 6292
    3'-5' exonuclease activity 3.0063E-5 2 35 2 6292
    exonuclease activity 5.2295E-5 2 46 2 6292
    ribonuclease activity 5.5711E-4 2 149 2 6292
    nuclease activity 9.9543E-4 2 199 2 6292
    hydrolase activity, acting on ester bonds 2.929E-3 2 341 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle