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Protein Overview: PIK1

General Information:
Name(s) found: PIK1 / YNL267W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1066 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Golgi apparatus [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: ascospore formation [IGILink to PubMed article][IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IDALink to PubMed article]
    post-Golgi vesicle-mediated transport [IGILink to PubMed article]
    inositol lipid-mediated signaling [TASLink to PubMed article]
    Molecular Function: 1-phosphatidylinositol 4-kinase activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKASSSKKS FDDTIELKKN EQLLKLINSS EFTLHNCVEL LCKHSENIGI HYYLCQKLAT  60
   61 FPHSELQFYI PQLVQVLVTM ETESMALEDL LLRLRAENPH FALLTFWQLQ ALLTDLSTDP 120
  121 ASYGFQVARR VLNNLQTNLF NTSSGSDKNV KIHENVAPAL VLSSMIMSAI AFPQLSEVTK 180
  181 PLVESQGRRQ KAFVFKLARS AMKDFTKNMT LKNTLLNKKT SRSKRVSSNR SSTPTSPIDL 240
  241 IDPIKTKEDA SFRKSRHSEV KLDFDIVDDI GNQVFEERIS SSIKLPKRKP KYLDNSYVHR 300
  301 TYDGKNINRD GSISNTAKAL DGNKGDYISP KGRNDENNEI GNNEDETGGE TEEDADALNS 360
  361 DHFTSSMPDL HNIQPRTSSA SSASLEGTPK LNRTNSQPLS RQAFKNSKKA NSSLSQEIDL 420
  421 SQLSTTSKIK MLKANYFRCE TQFAIALETI SQRLARVPTE ARLSALRAEL FLLNRDLPAE 480
  481 VDIPTLLPPN KKGKLHKLVT ITANEAQVLN SAEKVPYLLL IEYLRDEFDF DPTSETNERL 540
  541 LKKISGNQGG LIFDLNYMNR KENNENRNES TLTSNNTRSS VYDSNSFNNG ASRNEGLSST 600
  601 SRSDSASTAH VRTEVNKEED LGDMSMVKVR NRTDDEAYRN ALVIQSAANV PILPDDSQDR 660
  661 SPELNFGSNL DEVLIENGIN SKNIHSQTDA LADQMRVSAV MLAQLDKSPQ QLSESTKQIR 720
  721 AQIISSMKEV QDKFGYHDLE ALHGMAGERK LENDLMTGGI DTSYLGEDWA TKKERIRKTS 780
  781 EYGHFENWDL CSVIAKTGDD LRQEAFAYQM IQAMANIWVK EKVDVWVKRM KILITSANTG 840
  841 LVETITNAMS VHSIKKALTK KMIEDAELDD KGGIASLNDH FLRAFGNPNG FKYRRAQDNF 900
  901 ASSLAAYSVI CYLLQVKDRH NGNIMIDNEG HVSHIDFGFM LSNSPGSVGF EAAPFKLTYE 960
  961 YIELLGGVEG EAFKKFVELT KSSFKALRKY ADQIVSMCEI MQKDNMQPCF DAGEQTSVQL1020
 1021 RQRFQLDLSE KEVDDFVENF LIGKSLGSIY TRIYDQFQLI TQGIYS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASK10 ATG1 BMH2 KIC1 NTH1 PIK1 REG1 RFX1 SOG2 UBP11 YDR348C YNR014W
    View Details Gavin AC, et al. (2002) BMH1 BMH2 NTH1 NTH2 PIK1 PSK1 RTG2
    View Details Qiu et al. (2008) PIK1 VRG4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PIK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] MSA 3.009979 View MSA. No confident structure predictions are available.
    2 View Details [122..434] MSA 7.059997 View MSA. No confident structure predictions are available.
    3 View Details [435..692] PSI-BLAST 319.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    4 View Details [693..846]
    [989..1019]    		 PSI-BLAST 319.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    5 View Details [847..988]
    [1020..1066]    		 PSI-BLAST 319.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle