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Protein Overview: CKI1

General Information:
Name(s) found: CKI1 / YLR133W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 582 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: phosphatidylcholine biosynthetic process [TAS]
    Molecular Function: choline kinase activity [IDALink to PubMed article][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQESRPGSV RSYSVGYQAR SRSSSQRRHS LTRQRSSQRL IRTISIESDV SNITDDDDLR  60
   61 AVNEGVAGVQ LDVSETANKG PRRASATDVT DSLGSTSSEY IEIPFVKETL DASLPSDYLK 120
  121 QDILNLIQSL KISKWYNNKK IQPVAQDMNL VKISGAMTNA IFKVEYPKLP SLLLRIYGPN 180
  181 IDNIIDREYE LQILARLSLK NIGPSLYGCF VNGRFEQFLE NSKTLTKDDI RNWKNSQRIA 240
  241 RRMKELHVGV PLLSSERKNG SACWQKINQW LRTIEKVDQW VGDPKNIENS LLCENWSKFM 300
  301 DIVDRYHKWL ISQEQGIEQV NKNLIFCHND AQYGNLLFTA PVMNTPSLYT APSSTSLTSQ 360
  361 SSSLFPSSSN VIVDDIINPP KQEQSQDSKL VVIDFEYAGA NPAAYDLANH LSEWMYDYNN 420
  421 AKAPHQCHAD RYPDKEQVLN FLYSYVSHLR GGAKEPIDEE VQRLYKSIIQ WRPTVQLFWS 480
  481 LWAILQSGKL EKKEASTAIT REEIGPNGKK YIIKTEPESP EEDFVENDDE PEAGVSIDTF 540
  541 DYMAYGRDKI AVFWGDLIGL GIITEEECKN FSSFKFLDTS YL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CKI1 NAP1
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Ho Y, et al. (2002) CDC25 CKI1 GCR2 GIN4 HOM3 IRA1 IRA2 MYO2 MYO4 NAP1 PMD1 PRS2 PRS3 PRS5 RIM11 TPS1 TSL1 YDR170W-A YER138C YER160C YJR027W YJR028W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CKI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] deduced N/A No confident structure predictions are available.
    2 View Details [144..191]
    [205..218]    		 ORFEUS 12.95 Type IIIa 3',5"-aminoglycoside phosphotransferase
    3 View Details [192..204]
    [219..363]    		 ORFEUS 12.95 Type IIIa 3',5"-aminoglycoside phosphotransferase
    4 View Details [364..519] MSA 1.049982 View MSA. No confident structure predictions are available.
    5 View Details [520..582] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.77705138922602 bayes_pls_golite062009
  • protein kinase activity
    		•  4.68131600649845 bayes_pls_golite062009
  • kinase activity
    		•  4.63102094866388 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.26470104655954 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.92556971928915 bayes_pls_golite062009
  • transferase activity
    		•  3.27487631214089 bayes_pls_golite062009
  • binding
    		•  2.31186607166478 bayes_pls_golite062009
  • ATP binding
    		•  1.62950013799854 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.59120412984243 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.57251948653832 bayes_pls_golite062009
  • lipid kinase activity
    		•  1.3504796246251 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.32931505255952 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.32676572752438 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.31489723493061 bayes_pls_golite062009
  • nucleotide binding
    		•  1.31339663939554 bayes_pls_golite062009
  • protein binding
    		•  1.24858883313437 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • choline kinase activity
    		•  1.18757364210199 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.10484220525143 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.06634272225692 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05231366895645 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.04034573968654 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.97254836668426 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.957217569601377 bayes_pls_golite062009
  • ethanolamine kinase activity
    		•  0.68804237112665 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.380769480509274 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.22871167092767 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.185842548207239 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.134745748018448 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.0569871200546399 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.04117702615323 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle