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Protein Overview: MIA40

General Information:
Name(s) found: MIA40 / YKL195W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 403 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    mitochondrial outer membrane translocase complex [IDALink to PubMed article]
    Biological Process: protein import into mitochondrial intermembrane space [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    protein targeting [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNLVVRNA CRNRPSIQVA RGLCRHQTRR LMASSPQFGR NSNQEKTAGF IMGILSMAGA  60
   61 LYFIAPNRKP LFASRKVESD KTAEEELSSG GEQSPENEDD NNSKSDENGD DNDSKNDETE 120
  121 AGPQLGGDKI GASKVAEDGE LVVLAEEDNK SSEDKDTDES KVSTKDDEQS NEDNATANNQ 180
  181 KDENISSENS EENTSDKTLD NNAGSSEKKD PEHSDDEKSQ QGQSDDKTTT EDNNGEEESS 240
  241 KKTVSDSENS AKQSESSDEE KEELRKQEEK QMGPTEEEVQ HEGAYNPDTG EINWDCPCLG 300
  301 GMAHGPCGEE FKSAFSCFVY SEAEPKGIDC VEKFQHMQDC FRKYPEHYAE QLKETSDDEE 360
  361 PQDKVKVNTI ESAPNVSSAK ENAAKKAEQS DVKKEPLNEE SKP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) ADH1 KAP123 MIA40 TOM40
    View Details Krogan NJ, et al. (2006) MIA40 MUK1 PEP8 VPS17 VPS29 VPS35 VPS5
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CDC25 FAB1 HRK1 MDS3 MIA40 MRPL3 SAP155 SAP185 SAP190 SIT4 SWT21
    View Details Qiu et al. (2008) MIA40 TOM7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MIA40 and SPC42 Hazbun TR, et al. (2003)
    View Data MIA40 and TRX3 Hazbun TR, et al. (2003)
    View Data MIA40 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] MSA 1.173993 View MSA. No confident structure predictions are available.
    2 View Details [206..403] MSA 3.173995 View MSA. No confident structure predictions are available.
    3 View Details [247..403] MSA 1.186993 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle