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Protein Overview: APN1

General Information:
Name(s) found: APN1 / YKL114C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 367 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: base-excision repair [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: DNA-(apurinic or apyrimidinic site) lyase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    double-stranded DNA specific 3'-5' exodeoxyribonuclease activity [IDALink to PubMed article]
    phosphoric diester hydrolase activity [IDALink to PubMed article]
    3'-tyrosyl-DNA phosphodiesterase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSTPSFVRS AVSKYKFGAH MSGAGGISNS VTNAFNTGCN SFAMFLKSPR KWVSPQYTQE  60
   61 EIDKFKKNCA TYNYNPLTDV LPHGQYFINL ANPDREKAEK SYESFMDDLN RCEQLGIGLY 120
  121 NLHPGSTLKG DHQLQLKQLA SYLNKAIKET KFVKIVLENM AGTGNLVGSS LVDLKEVIGM 180
  181 IEDKSRIGVC IDTCHTFAAG YDISTTETFN NFWKEFNDVI GFKYLSAVHL NDSKAPLGAN 240
  241 RDLHERLGQG YLGIDVFRMI AHSEYLQGIP IVLETPYEND EGYGNEIKLM EWLESKSESE 300
  301 LLEDKEYKEK NDTLQKLGAK SRKEQLDKFE VKQKKRAGGT KRKKATAEPS DNDILSQMTK 360
  361 KRKTKKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APN1 YPD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..367] PSI-BLAST 688.67837 Endonuclease IV

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • deoxyribonuclease activity
    		•  1.46354552309786 bayes_pls_golite062009
  • catalytic activity
    		•  1.28975577984201 bayes_pls_golite062009
  • binding
    		•  1.21937946213086 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.960974549724719 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  0.952482439706792 bayes_pls_golite062009
  • nuclease activity
    		•  0.476817046894313 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.250454213851443 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  0.17972995021274 bayes_pls_golite062009
  • protein binding
    		•  0.0986812836806968 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle