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Protein Overview: TUL1

General Information:
Name(s) found: TUL1 / YKL034W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMPLink to PubMed article]
    protein ubiquitination [IMPLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIDGNTLVF IIVILFLFFS SPGGDGVSSQ YEFNQLQRLK QQFRTEHNTF VNMTYTDSFR  60
   61 NITGLKLSYQ DMLNNPLQNA TYPLPGKDYD RWFPNQNYMV LPNDVIEAIN TEVWNTSNDD 120
  121 ASNLFPPNIT STLLGKIDLV SNNKYEKIRM PVPRFYEPAT DFSEDIPPEG ETYWSEWPSY 180
  181 GELHNVSFQH GEIAIQISHM SNLQDNNNYL RRNFINKKND RWKLLNLQID FSDKAEKEKH 240
  241 SIYSKAVYDI QRGRILSISQ SSKFHSLFAL PHYMSFQNDY NEKIFNDVKE LVDEFWNFTD 300
  301 YTDVMTMKDV QDAYNNANFK CEYLIFLQLE PWNQYTRDQI KLIDDELNWP LGRPANLSSL 360
  361 PPINVVSGLL YSPDCGVRLG LHNVKGTRYE LKIMSIRKHL LFGIALFAAQ IYLLLTQMHH 420
  421 TNTPSMVNKI SFYCFSMINL VDGSLATLYF VAASVVPELY LPLVISAFSC FILASIFEIR 480
  481 YLISIYASQV NEQNVGIINL LRGNTGTYDE NRPRPAFIPD EGSIGGSLYG RFFFMLIIFT 540
  541 FLILSSTSWP RQLRMVFEYI LIFILNSYWI PQIFRNAVKG IPSRRERARS SIGGNRSQNK 600
  601 MPLLWSFVIG TTIIRSLPVV YVFTYSSNVF RHHKDVHFVV FLSLWLLFQI SILYSQDVLG 660
  661 SRWFLPKHTI PDGYSYFKPL SNEYISEHGG GTAEHTVDCA ICMSDVPIYI EEIPETHKVD 720
  721 QHSYMVTPCN HVFHTSCLEN WMNYKLQCPV CRSPLPPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..360] deduced N/A No confident structure predictions are available.
    2 View Details [361..597] MSA 1.112969 View MSA. No confident structure predictions are available.
    3 View Details [598..693] deduced N/A No confident structure predictions are available.
    4 View Details [694..758] PSI-BLAST 7.69897 Immediate early protein, IEEHV
    5 View Details [678..758] PSI-BLAST 13.69897 EL5 RING-H2 domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.32809533104435 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.17943669371679 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.2482314105959 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • binding
    		•  1.76493579130903 bayes_pls_golite062009
  • protein binding
    		•  1.73461977726143 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  0.786612602432575 bayes_pls_golite062009
  • ligase activity
    		•  0.63517530468004 bayes_pls_golite062009
  • peptidase activity
    		•  0.592030999071526 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.549461161056205 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.349795095432233 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.159023519781458 bayes_pls_golite062009
  • hydrolase activity
    		•  0.156835837705934 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.125491277540945 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle