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Protein Overview: AGX1

General Information:
Name(s) found: AGX1 / YFL030W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glycine biosynthetic process, by transamination of glyoxylate [IDALink to PubMed article]
    Molecular Function: alanine-glyoxylate transaminase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSVDTLLI PGPIILSGAV QKALDVPSLG HTSPEFVSIF QRVLKNTRAV FKSAAASKSQ  60
   61 PFVLAGSGTL GWDIFASNFI LSKAPNKNVL VVSTGTFSDR FADCLRSYGA QVDVVRPLKI 120
  121 GESVPLELIT EKLSQNSYGA VTVTHVDTST AVLSDLKAIS QAIKQTSPET FFVVDAVCSI 180
  181 GCEEFEFDEW GVDFALTASQ KAIGAPAGLS ISLCSSRFMD YALNDSKNGH VHGYFSSLRR 240
  241 WTPIMENYEA GKGAYFATPP VQLINSLDVA LKEILEEGLH KRWDLHREMS DWFKDSLVNG 300
  301 LQLTSVSRYP SNMSAHGLTA VYVADPPDVI AFLKSHGVVI AGGIHKDIGP KYIRIGHMGV 360
  361 TACNKNLPYM KNCFDLIKLA LQRKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADH4 ADK1 AGX1 AHA1 CDC33 CPR1 DUN1 HOM2 PCL7 PDX3 PGM2 PHO81 PHO85 SOD1 TMA29 VMA4 YHB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AGX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..10]
    [281..385]    		 PSI-BLAST 76.09691 NifS-like protein/selenocysteine lyase
    2 View Details [11..280] PSI-BLAST 76.09691 NifS-like protein/selenocysteine lyase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alanine-glyoxylate transaminase activity
    		•  5.09067995370888 bayes_pls_golite062009
  • serine-pyruvate transaminase activity
    		•  3.41330924856745 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  3.04830539911875 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  3.04830539911875 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  2.30133284041702 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  2.1692959843619 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  1.1251558546682 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • binding
    		•  0.513318446274735 bayes_pls_golite062009
  • L-allo-threonine aldolase activity
    		•  0.500744432308415 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.093175965161657 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0150995688991599 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle