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Protein Overview: WBP1

General Information:
Name(s) found: WBP1 / YEL002C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    oligosaccharyltransferase complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    Biological Process: protein amino acid N-linked glycosylation [IPILink to PubMed article]
    cell cycle [IDALink to PubMed article]
    Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTDWNFFFC ILLQAIFVVG TQTSRTLVLY DQSTEPLEEY SVYLKDLEQR NYKLEYLDIN  60
   61 STSTTVDLYD KEQRLFDNII VFPTKGGKNL ARQIPVKQLI KFFENEGNIL CMSSPGAVPN 120
  121 TIRLFLNELG IYPSPKGHVI RDYFSPSSEE LVVSSNHLLN KYVYNARKSE DFVFGESSAA 180
  181 LLENREQIVP ILNAPRTSFT ESKGKCNSWT SGSQGFLVVG FQNLNNARLV WIGSSDFLKN 240
  241 KNQDSNQEFA KELLKWTFNE KSVIKSVHAV HSHADGTSYD EEPYKIKDKV IYSVGFSEWN 300
  301 GEEWLPHIAD DIQFELRQVD PYYRLTLSPS GNDSETQYYT TGEFILPDRH GVFTFLTDYR 360
  361 KIGLSFTTDK DVKAIRHLAN DEYPRSWEIS NSWVYISAIC GVIVAWIFFV VSFVTTSSVG 420
  421 KKLETFKKTN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) OST1 OST2 OST3 OST4 OST5 OST6 STT3 SWP1 WBP1
    View Details Krogan NJ, et al. (2006) GPD1 PDR5 PHO86 PMA1 PMT1 SSH1 WBP1 YGR266W
    View Details Gavin AC, et al. (2006) OST1 STT3 SWP1 WBP1
    View Details Gavin AC, et al. (2002) ERO1 OST1 OST6 SEC13 SEH1 STT3 SWP1 TIF34 WBP1
    View Details Ho Y, et al. (2002) KTR3 MNN9 SLC1 VAN1 WBP1
    View Details Qiu et al. (2008) ALG13 ALG2 ALG8 LAG1 OST1 OST2 OST3 OST4 OST5 OST6 PMT1 SBH2 STT3 SWP1 WBP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data WBP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] Pfam 290.619789 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kD subunit No confident structure predictions are available.
    2 View Details [282..430] MSA 2.041948 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.21522719658673 bayes_pls_golite062009
  • binding
    		•  1.10799322720495 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.00678459791194 bayes_pls_golite062009
  • ligase activity
    		•  0.952686615697528 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle