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Protein Overview: BDH2

General Information:
Name(s) found: BDH2 / YAL061W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP IFFPEDGHTH  60
   61 EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT GTCRDRYRWP LSPNVDKEWC 120
  121 AACKKGYYNI CSYLGLCGAG VQSGGFAERV VMNESHCYKV PDFVPLDVAA LIQPLAVCWH 180
  181 AIRVCEFKAG STALIIGAGP IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP 240
  241 TAHAAKESID YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ 300
  301 FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN IEDGLDGAIM 360
  361 KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK DQERLRESIN EAKLRHT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BDH1 BDH2
    View Details Krogan NJ, et al. (2006) BDH1 BDH2
    View Details Gavin AC, et al. (2002) BDH2 PSE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ARF3 BDH2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BDH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173]
    [344..417]    		 PSI-BLAST 463.24799 Ketose reductase (sorbitol dehydrogenase)
    2 View Details [174..343] PSI-BLAST 463.24799 Ketose reductase (sorbitol dehydrogenase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-iditol 2-dehydrogenase activity
    		•  3.00103406168296 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • chaperone binding
    		•  2.79912653573494 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.39817482511246 bayes_pls_golite062009
  • L-arabinitol 2-dehydrogenase activity
    		•  0.382131941157781 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.36426941921419 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
    		•  0.361275519814065 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • binding
    		•  0.311888962066118 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase activity
    		•  0.298691872199351 bayes_pls_golite062009
  • ATPase activity
    		•  0.275256680720412 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.179327587154303 bayes_pls_golite062009
  • DNA binding
    		•  0.0742540086107448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle